Questions about Obesity
Are gut metabolites linked to obesity and conditions like fatty liver?
Yes, gut metabolites like short-chain fatty acids and bile acids are linked to obesity and fatty liver, with dysbiosis driving inflammation and metabolic dysfunction.
Full answer →Are there rising trends in severe obesity prevalence among children and adolescents in the US?
Data from the US National Health and Nutrition Examination Survey shows that severe obesity in children and adolescents aged 2 to 19 years more than doubled between 1999 and 2018.
Full answer →Does a group-based weight management program work for people with severe obesity?
Group-based programs like PROGROUP and Compassion Focused Therapy show promise for people with severe obesity by improving psychological outcomes and helping deliver complex interventions.
Full answer →How does a low-fat diet affect muscle mass in adults with obesity?
A low-fat diet leads to modest muscle loss in adults with obesity, but combining it with resistance exercise can help preserve muscle.
Full answer →Do women with obesity lose more weight on GLP-1 drugs than men?
Yes, research shows women with obesity tend to lose more weight on GLP-1 drugs than men, though the difference is modest and varies by individual factors.
Full answer →Do digital lifestyle interventions help adults with obesity lose weight?
Yes, stand-alone digital lifestyle interventions help adults with obesity lose weight and improve diet quality, though results vary by program design and engagement.
Full answer →What factors influence eating behaviors in adults with obesity?
Eating behaviors in adults with obesity are influenced by psycho-emotional factors (stress, impulsivity), socio-environmental stressors (work, relationships), and maladaptive patterns like rapid eating and irregular meal timing.
Full answer →Is tirzepatide as effective as sleeve gastrectomy for obesity?
A 2024 network meta-analysis found tirzepatide and sleeve gastrectomy produce equivalent weight loss (about 21% total body weight), but individual results vary and surgery offers durable long-term outcomes.
Full answer →All Obesity Articles
- Ramped position provides comparable first-pass success to sniffing position for intubating obese patients
- Tirzepatide reduces inflammatory markers and improves metabolic biomarkers in patients with obesity
- Community health worker-led interventions reduce systolic blood pressure by 5.5 mm Hg
- Exercise training prevents 45.7% of fat-free mass loss during calorie restriction in overweight and obese individuals
- Abdominoplasty complications show no significant difference between patients with and without history of metabolic surgery
- LSG associated with lower readmission rates than LRYGB in outpatient bariatric surgery settings
- Metabolic bariatric surgery linked to lower breast cancer risk in women with obesity
- SASI bypass results in mean total weight loss of 35.9 kg after 12 months
- 16-week behavioral intervention reduces caloric intake by 461 ± 931 kcal/day and UPF proportion
- High-intensity interval training associated with -0.73% HbA1c reduction in adults with type 2 diabetes
- High Intensity Interval Training Improves Cardiometabolic Risk Factors in Pediatric Overweight Populations
- Efficacy and Safety Profile of Subcutaneous Semaglutide for Weight Management in Adults
- Obesity is associated with lower PASI90, PASI75, and PASI100 responses in patients with psoriasis
- Sarcopenic obesity may impair bone formation and reduce mineral content in children and adolescents
- High-intensity interval training reduces body weight and fat mass more than moderate-intensity continuous training
- Dextrins may increase circulating GLP-1 concentrations and satiety in adults with limited evidence certainty
- Dietary interventions may influence obesity and depressive symptoms through multiple metabolic and neurological pathways
- Oral small-molecule GLP-1RAs reduce body weight by 3.93 and HbA1c by 0.94
- Citrus bergamia nutraceuticals significantly reduce body weight and BMI in patients with obesity
- Roux-en-Y gastric bypass and sleeve gastrectomy produce distinct and durable post-operative hormonal profiles
- Combined Aerobic and Resistance Training Improves Metabolic Markers in Overweight Adolescents
- Gut microbiota may influence metabolic response to GLP-1 receptor agonists in obesity and type 2 diabetes
- Intermittent fasting plus early time-restricted eating results in greater weight loss than standard care
- Lymphatic dysfunction may drive inflammation and insulin resistance in older adults with sarcopenic obesity
- Bariatric surgery is associated with a significantly lower incidence of gallbladder cancer in people living with obesity
- GLP-1 receptor agonists are associated with a 3.587 risk ratio for hair loss in obese patients
- Semaglutide significantly reduces BMI and improves hypertension control in patients with obesity and CKD
- Probiotic fermentation of herbal residues may enhance bioactive compounds and gut-liver axis for obesity
- Whey protein may mitigate body weight loss and preserve fat-free mass after bariatric surgery
- Open Rives-Stoppa retrorectus mesh repair resolves gastric outlet obstruction in a patient with class III obesity
- Elecoglipron results in 40.4% to 88.8% of patients reaching at least 5% weight loss
- Aerobic exercise and high-intensity interval training reduce fat mass in women with overweight or obesity
- Single-incision sleeve plus bypass shows short-term safety and metabolic improvement in 3 patients with obesity and T2DM
- Tirzepatide at maximum tolerated dose achieved 21.9% bodyweight reduction over 112 weeks
- Exercise interventions may improve adiposity and physical function in middle-aged or older adults with sarcopenic obesity
- Intensive lifestyle intervention protocol designed to identify predictors of weight loss success
- Evolocumab reduces MACE by 29% in patients with BMI greater than or equal to 35 kg/m
- Traditional Chinese Medicine reduces body weight by 5.86 kg and improves lipid profiles in obesity
- Food insecurity linked to poorer diet and higher obesity risk in older adults
- Semaglutide associated with 35.2% of weight loss as lean mass versus 26.2% with lifestyle interventions
- Oral white kidney bean extract reduces weight by 1.62 kg in adults with overweight or obesity compared to placebo
- Obesity in older adults lowers Alzheimer's risk while underweight status and weight loss increase it
- Semaglutide Improves Metabolic Health in Schizophrenia Patients on Antipsychotics
- Modulating endogenous PYY expression offers a theoretical basis for individualized obesity management strategies
- Tirzepatide maximum tolerated dose leads weight reduction ranking in obesity network meta-analysis
- Eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity
- Metabolic and bariatric surgery significantly reduces plasma Fetuin-A levels in patients with obesity
- Ring-augmented gastric bypass shows similar weight loss and safety at one year
- Semaglutide 1.7 mg shows comparable BMI reduction to 2.4 mg in adolescents and adults
- Preoperative GLP-1 agonists yield moderate weight loss before bariatric surgery, meta-analysis finds
- Risk factors for sarcopenic obesity in older adults include age, physical inactivity, diabetes, and hypertension
- Metabolic and bariatric surgery yields significant body weight variations in sarcopenic obesity versus non-sarcopenic obesity
- Metabolic syndrome linked to higher risk of several obesity-related cancers and worse colorectal cancer survival
- Mazdutide reduces percentage body weight by 12.42% in non-diabetic adults with obesity across five RCTs
- Cagrisema produces greater weight loss than semaglutide in obesity meta-analysis
- Bariatric surgery yields greater long-term weight loss than GLP-1 receptor agonists in adults with obesity
- Tirzepatide improves waist-to-height ratio in adults with obesity or overweight
- Exercise Improves Body Composition and Function in Sarcopenic Obesity
- Systematic review shows pre-pregnancy weight loss interventions do not significantly reduce gestational diabetes mellitus risk in women with overweight or obesity
- Exclusive breastfeeding reduces childhood obesity risk in high-income countries
- Wearable activity tracker adherence associated with reduced body fat in a 12-month randomized trial
- Overweight and obesity linked to increased bladder cancer risk in males in meta-analysis
- Narrative Review Explores Gut Microbiota in Precision Nutrition for Obesity
- Systematic review links metabolic dysregulation to impaired oocyte quality and embryonic development potential
- Digital toolkit for weight management failed to improve weight loss maintenance in European adults
- Narrative review on BAT in older adults with obesity and exercise nutrition
- Systematic review and meta-analysis of metformin for pediatric overweight and obesity shows modest BMI reduction
- Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
- Meta-analysis of Mendelian randomization suggests GLP-1 receptor agonism lowers vascular dementia risk
- Review of tart cherry effects in overweight and obesity reports inconsistent metabolic findings
- Meta-analysis shows intermittent fasting lowers BMI and fasting glucose in women with overweight or obesity
- CagriSema demonstrates superior weight loss efficacy compared to semaglutide monotherapy or placebo in obesity trials
- Systematic review and meta-analysis shows combined exercise and 16:8 time-restricted eating reduces weight in adults
- Pediatric Gut Microbiome Links to Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
- Systematic Review Finds Food Addiction Prevalence Varies Widely in Indian Population
- Meta-analysis of GWAS in Native Hawaiians and Polynesians identifies 25 trait loci for diabetes and obesity traits
- Bayesian network meta-analysis compares tirzepatide, liraglutide, and semaglutide for weight reduction in adults without diabetes
- Protocol for future review on acupoint catgut embedding for abdominal obesity and insulin resistance
- Systematic review links psycho-emotional and environmental factors to eating behaviors in adults with overweight or obesity
- Narrative review links ultra-processed foods to weight gain and metabolic dysfunction via matrix effects
- Stand-alone digital lifestyle interventions show significant improvements in weight and dietary habits for adults with overweight or obesity compared to controls
- Network Meta-Analysis Finds Tirzepatide and Sleeve Gastrectomy Equally Effective for Weight Loss in Obesity
- GLP-1 receptor agonists show greater weight loss in women than men across multiple trials
- Low-fat or low-carb diet weight loss shows modest appendicular lean tissue decrease in adults with obesity
- INSTI switching linked to higher metabolic risk in people with HIV
- Guideline on severe pediatric obesity with MC4R variant and puberty management
- Propofol-first sequence reduces hypoxemia in obese patients undergoing gastroscopy
- Semaglutide improves physical quality of life in schizophrenia with prediabetes
- Mediterranean diet plus physical activity reduces postprandial triglyceridemia in adults with abdominal obesity
- Weight Regain Reverses Caloric Restriction Benefits on Insulin-IGF-1 Pathway and Biological Age
- Wholegrain rye diets improve metabolic markers but not weight loss in overweight adults
- Energy restriction with ultra-processed food restriction yields greater weight loss than generic energy restriction in obesity
- Semaglutide reduces insulin dose in adults with type 1 diabetes and obesity
- Extended sleep improved sleep metrics but did not change insulin sensitivity in a small trial
- Exploratory analysis of RYGB and SG shows variable LDL cholesterol response in patients with obesity and high LDL cholesterol
- Systematic Review and Meta-Analysis: Bariatric Surgery Reduces Low Back Pain in Morbid Obesity
- Meta-analysis shows combined bariatric and body contouring surgery improves quality of life and weight loss versus bariatric surgery alone
- Afternoon/Evening Exercise May Lower Blood Pressure More Than Morning Exercise: Meta-Analysis
- Umbrella review identifies risk factors and protective factors for male infertility and semen quality
- Systematic review shows regional differences in HS comorbidity prevalence across North America, Europe, and Asia
- Oral Sodium Butyrate Reduces Weight in Overweight Adults Without Diabetes
- Essential phospholipids reduced hepatic steatosis and improved HbA1c in patients with MASLD and type 2 diabetes over 6 months
- Naltrexone-Bupropion Aids Weight Loss in Overweight Adults With Depression
- Intensive lifestyle intervention improves health-related quality of life in patients with obesity
- Emotional eating shows stronger link to elevated BMI in adults than youth in this meta-analysis
- Systematic review and meta-analysis shows small BMI reduction in preschoolers with screen-time interventions
- Bayesian network meta-analysis compares exercise modalities for systemic inflammation in postmenopausal women
- Narrative review links ultra-processed food to obesity and multiple metabolic conditions
- Meta-analysis shows dietary nitrate supplementation lowers systolic blood pressure and cholesterol in adults with obesity
- Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes
- Narrative review explores gut metabolites postbiotics obesity fatty liver and bone loss associations
- Multicomponent lifestyle interventions impact dietary habits and sleep duration in college-attending young adults
- Semaglutide high dose for weight reduction in people with Type 2 Diabetes
- Retrospective Cohort Profile Describes Preconception Metabolic-Bariatric Surgery Study Design for Birth Outcomes
- Network Meta-Analysis Finds Tirzepatide and Semaglutide Most Effective for Weight Loss in Adults
- Protocol for culturally adapted cardiovascular dance intervention in Mapuche women with obesity and cardiometabolic disorders
- Narrative review links microgravity exposure to altered fat distribution and inflammation in metabolic disease models
- MCH1 Receptor Antagonist RGH-706 Shows Weight Loss in Preclinical and Early Clinical Study
- Longitudinal ABCD Study links central fat dynamics to cognitive deficits in adolescents
- Narrative review on dyslipidemia and erectile dysfunction pathophysiology
- GZR18 showed weight loss in Chinese adults with overweight or obesity in a phase 1b/2a trial
- Randomized trial finds konjac glucomannan reduces weight and cardiometabolic markers in excess weight adults
- Systematic review of antioxidant and anti-inflammatory strategies for male infertility and immune-mediated testicular disorders
- Narrative review compares tirzepatide and semaglutide for obesity and type 2 diabetes outcomes
- Tirzepatide MTD Demonstrates Cost-Effectiveness Versus Semaglutide MTD in Obesity Simulation Modeling Study
- IGFBP2 as a context-dependent regulator of metabolic dysregulation in obesity and type 2 diabetes
- Narrative review covers IBD, bile acid malabsorption, IBS-D, CRC, obesity, NAFLD, and sepsis-related intestinal injury
- Obesity associated with reduced SLE relapse rates in Japanese registry cohort
- Narrative review explores links between antibiotic exposure and obesity or metabolic phenotypes
- Adjuvanted RSV vaccine shows efficacy against RSV disease in older adults with comorbidities
- Narrative review explores adipose tissue macrophage regulation for obesity and metabolic disorders
- Protocol for coarse-cereal substitution in school meals to prevent obesity in Chinese primary students
- Weight stigmatization increases physiological stress and appetite markers in women with obesity over 120 minutes
- Narrative review: high-fiber breakfast cereals and wheat bran support digestive and cardiometabolic health
- Meta-analysis of minimally invasive vs open hepatectomy in patients with obesity and liver tumors
- Review summarizes pre-post trial on black tea kombucha effects in obesity
- Theory-informed behavioural intervention reduces ultra-processed food intake and weight in UK adults
- Meta-analysis links ultra-processed food intake to higher odds of adolescent overweight/obesity
- Preprint paired analysis suggests VSG may improve metabolic and renal markers in youth with T2D and obesity
- L-citrulline with HIIT alters specific microRNAs in obese older adults
- Network meta-analysis finds metabolic surgery superior to GLP-1 agonists for weight loss in obesity
- GLP1R locus variants associated with higher BMI and Type 2 Diabetes risk in genetically inferred European ancestry participants
- Endocrine-disrupting chemicals may contribute to obesity and adiposity in humans
- Single aerobic exercise bout shows mixed effects on glucose and neuronal insulin signaling in obesity
- Cultural dietary patterns linked to lower obesity risk in global meta-analysis
- Post-hoc analysis finds both continuous and intermittent calorie restriction reduce weight in type 2 diabetes
- GLP-1 agents and cognitive interventions address obesity and eating disorders via appetite and gut-brain signaling pathways
- Review of quercetin in metabolic diseases shows promise but lacks clinical validation
- Maternal obesity linked to altered DNA methylation of iron-regulating genes in early pregnancy
- Pregnant women with prior bariatric surgery experienced 35 surgical complications in a Belgian cohort study
- Meta-analysis finds liraglutide improves menstrual frequency and BMI in overweight women with PCOS
- Overweight status at diagnosis in Kuwaiti children with new-onset type 1 diabetes is associated with milder clinical presentation and lower HbA1c
- Full-fat dairy vs. low-fat dairy with energy restriction for weight and metabolic outcomes in adults with overweight/obesity
- Sleeve-fundoplication without gastric resection reduces GERD incidence versus sleeve gastrectomy in obese rat model
- Mendelian randomization meta-analysis links genetically predicted obesity traits to increased heart failure risk
- Mexican cohort study reports allele frequencies for six obesity-associated genetic variants
- Oral denatonium acetate (ARD-101) reduced weight versus placebo in adults with obesity over 28 days
- Diet and detox teas show minimal weight loss benefits and potential serious health risks in otherwise healthy individuals
- Personalized nutrition and behavioral correction address feline obesity and associated comorbidities like diabetes and osteoarthritis
- Elevated plasma phenylalanine associated with obesity, type 2 diabetes, and cancer risk
- Systemic inflammation mediates links between sleep, obesity, and musculoskeletal pain but not consistently for psychological factors
- HFpEF probability scores rule out disease but show limitations in AF and obesity phenotypes
- In healthy adults, a 5-day fasting intervention acutely reduced BMI and altered gut microbiome and metabolite profiles
- Extended overnight fasting improves nighttime blood pressure dipping in overweight/obese adults
- Primary care clinicians report readiness for GLP-1 obesity care but note gaps in behavioral intervention competence
- Meta-analysis finds distinct neural activation patterns to food and monetary rewards in overweight/obesity
- Cognitive training add-on to behavioral weight-loss intervention shows moderate BMI reductions at 6 months
- GLP-1 receptor agonists associated with lower respiratory sequelae risk in case report analysis
- Phase II RCT: Amiloride reduces arterial stiffness and blood pressure in adults with obesity and metabolic syndrome
- Phase 1b trial of oral GLP-1 agonist HDM1002 shows weight reduction in Chinese adults with overweight/obesity
- Qualitative study explores Mexican mothers' perspectives on peer-led childhood obesity prevention
- HIIT plus Spirulina supplementation alters inflammatory biomarkers in young men with obesity
- Liraglutide reduces OSA severity in patients with COPD and obesity in exploratory analysis
- Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
- GLP-1RAs reduce MACE risk in Asian and White adults with diabetes or overweight
- Plant bioactive polysaccharides show metabolic benefits in umbrella review of systematic reviews
- Prediabetes in youth with overweight/obesity associated with lower baseline cognition, stable over 2 years
- Short-term liraglutide modulates proteins in obesity, showing weight-independent effects and myostatin suppression
- Horseshoe-like plantar hyperkeratosis associated with prediabetes in overweight adults
- Nutrition and health canteen intervention linked to weight reduction in middle-aged adults
- FDA Approves FOUNDAYO (orforglipron) for chronic weight management in adults with obesity or overweight with comorbidities
- NHANES data show rising obesity and severe obesity prevalence in US youth aged 2-19 years
- Hospitalized pregnant women with COVID-19 had higher prepregnancy obesity and gestational diabetes prevalences
- US study examines obesity prevalence among children and adolescents aged 2-19 years
- Post hoc analysis links WHtR threshold to remission in obesity management with tirzepatide vs semaglutide
- High BMI polygenic risk score linked to faster weight regain in postmenopausal European American women
- Walking program improves liver enzymes and BMI in children with PKU and NAFLD
- PAP therapy reduces pulmonary arterial pressures in patients with severe OSA or OHS
- Lorcaserin reduces weight and fat mass, alters lipidomics in 48 adults with obesity over 6 months
- Scuba-diving and mindfulness program reduces emotional eating in adults with obesity in small trial
- Phase 1 trial of once-weekly eloralintide shows weight reduction in obesity over 12 weeks
- Myosteatosis and visceral obesity show small associations with minor postoperative complications after colorectal surgery
- Bariatric surgery associated with lower cardiovascular risks than GLP-1RA therapy in adults with obesity
- Sarcopenic obesity prevalence is 28% in adults with advanced knee OA and severe obesity
- Tirzepatide improves patient-reported physical function in adults with overweight or obesity
- GLP-1RA use associated with lower obesity-related cancer risk in meta-analysis of adults with T2DM/obesity
- Network meta-analysis compares exercise types for insulin resistance in youth with overweight or obesity
- Systematic review maps gut microbiome–epigenetic crosstalk in obesity and type 2 diabetes
- Mediterranean lifestyle intervention reduces BMI, fat mass in preschool girls at risk of obesity
- Feasibility RCT Evaluates Group-Based Weight Management Program for Severe Obesity