N/A N=51 Randomized Single-blind Treatment

The Effect of Exercise on Individuals With Parkinson's Disease

Parkinson's Disease

Bottom Line

View on ClinicalTrials.gov: NCT00591344 ↗

Enrolled (actual)

Serious AEs

27.5%

Results posted

Feb 2015

Primary outcome: Primary: Off Medication UPDRS Part III, Motor Subscale Score — 34.7; 34.5; 29.3; 28.0 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Progressive resistance training (Behavioral); Modified Fitness Counts (Behavioral)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: University of Illinois at Chicago
Primary completion: Jul 2011

Outcome Measures

Outcome	Result	p-value
PRIMARY Off Medication UPDRS Part III, Motor Subscale Score	34.7; 34.5; 29.3; 28.0; 32.8; 28.4	—
SECONDARY On Medication UPDRS-III	20.9; 21.6; 17.7; 19.1; 19.1; 19.4	—
SECONDARY L-dopa equivalent-mg/Day	704.5; 597.8; 741.2; 619.0; 772.2; 638.1	—
SECONDARY Elbow Flexion Strength	—	—
SECONDARY Ankle Plantar Flexion Strength	—	—
SECONDARY Elbow Extension Strength	—	—
SECONDARY Ankle Dorsiflexion Strength	—	—
SECONDARY Percentage of Agonist EMG Signal Contained in the 0-5, 5-15, 15-30, and 35-50 Hz Frequency Bins During Isometric Contractions	—	—
SECONDARY The Integral of the First Agonist Burst	—	—
SECONDARY Magnitude of the First 30 ms of the Agonist Burst	—	—
SECONDARY Magnitude of the Antagonist Burst	—	—
SECONDARY Magnitude of the Agonist Burst	—	—
SECONDARY Duration of First Agonist Burst	—	—
SECONDARY Number of Agonist Bursts	—	—
SECONDARY Co-contraction During Limb Acceleration	—	—
SECONDARY Qant	—	—
SECONDARY Time to Peak Velocity	—	—
SECONDARY Peak Movement Velocity	—	—
SECONDARY Relaxation Time	—	—
SECONDARY Rise Time	—	—
SECONDARY Spatiotemporal Gait Analysis	—	—
SECONDARY Distance Walked in 6 Minutes	—	—
SECONDARY Modified Physical Performance Test	—	—
SECONDARY Time on the Timed up and go Test	—	—
SECONDARY Berg Balance Scale Score	—	—
SECONDARY Functional Reach	—	—
SECONDARY Cognitive Function - Stroop Test	—	—
SECONDARY Cognitive Function - Brief Test of Attention	—	—
SECONDARY Cognitive Function - Digit Span Forward/Backward	—	—
SECONDARY Parkinson 's Disease Quality of Life	—	—
SECONDARY Epworth Sleepiness Scale	—	—
SECONDARY Beck's Depression Inventory	—	—
SECONDARY 50 ft Walk Time	—	—
SECONDARY 50 Foot Walk Speed	—	—
SECONDARY 5 Time Sit to Stand	—	—

Summary

The goal of this trial is to compare the effect of two different exercise programs on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease to determine which program is most beneficial.

Eligibility Criteria

Inclusion Criteria

a diagnosis of PD
Up to the age of 67
on at least 1 DA drug, may be on several PD medications
able to walk for six minutes (may take rest breaks)
able to come off their PD medication for testing (12 hour overnight withdrawal of antiparkinsonian medications)
able to stay on stable PD medications for at least 6 months
live within a 30 mile radius of Chicago
Hoehn and Yahr Score: II - III while in the "Off" PD medication state

Exclusion Criteria

history of any other neurological disorder as determined by medical history and neurological exam
history of a known injury, disease, or other disorder that might interfere with motor function in the proposed experiments
a score less than 23 on the Mini-Mental State Examination
currently involved in an active, ongoing formal exercise program deep brain stimulation surgery
known cardiac problem or significant hypertension
depression that may interfere with regular exercise
hallucinations or being treated for hallucinations

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00591344). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.