Phase 1 Completed N=25 Randomized Triple-blind Treatment

Transcranial Magnetic Stimulation to Improve Speech in Aphasia

aphasia · Cerebrovascular Stroke

Source: ClinicalTrials.gov NCT00608582 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2017

Primary outcomePrimary: Picture Naming — 10.3; 12.57; 12.1; 11.14 number of pictures — p=<0.028

Summary

The purpose of this study is to examine whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with aphasia. Aphasia patients can have problems with speech production. The rTMS procedure allows painless, noninvasive stimulation of human cortex from outside the head. Chronic aphasia patients have been observed in our functional magnetic resonance brain imaging studies to have excess brain activation in brain areas possibly related to language on the right side of the brain (opposite side to where the stroke took place). It is expected that suppression of activity in the directly targeted brain region will have an overall modulating effect on the neural network for naming (and propositional speech) and will result in behavioral improvement.

Outcome Measures

Outcome	Result	p-value
PRIMARY Picture Naming	10.3; 12.57; 12.1; 11.14	<0.028 sig
PRIMARY Phrase Length	5.2; 5.285; 5.7; 5.0	0.414

Eligibility Criteria

Inclusion Criteria

Right Handed
Single, Left Hemisphere Cerebrovascular Stroke
Must be at least 6 months poststroke onset
Native Speaker of English
Clinical Diagnosis of Aphasia

Exclusion Criteria

Intracranial metallic body from prior neurosurgical procedure
Implanted metallic devices: pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit or ventriculoperitoneal shunt
Past history of seizure within 1 year
Pregnancy
History of substance abuse within last 6 months

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00608582). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.