Phase 1
N=25
Transcranial Magnetic Stimulation to Improve Speech in Aphasia
Aphasia · Cerebrovascular Stroke
Bottom Line
View on ClinicalTrials.gov: NCT00608582 ↗Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Jan 2017
Primary outcome: Primary: Picture Naming — 10.3; 12.57; 12.1; 11.14 number of pictures — p=<0.028
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 1
- Interventions
- Transcranial Magnetic Stimulation, Repetitive (Device)
- Age
- Adult, Older Adult · 45+ yrs
- Sex
- All
- Sponsor
- Boston University
- Primary completion
- Jun 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Picture Naming |
10.3; 12.57; 12.1; 11.14 | <0.028 sig |
| PRIMARY Phrase Length |
5.2; 5.285; 5.7; 5.0 | 0.414 |
Summary
The purpose of this study is to examine whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with aphasia. Aphasia patients can have problems with speech production. The rTMS procedure allows painless, noninvasive stimulation of human cortex from outside the head.
Chronic aphasia patients have been observed in our functional magnetic resonance brain imaging studies to have excess brain activation in brain areas possibly related to language on the right side of the brain (opposite side to where the stroke took place). It is expected that suppression of activity in the directly targeted brain region will have an overall modulating effect on the neural network for naming (and propositional speech) and will result in behavioral improvement.
Eligibility Criteria
Inclusion Criteria
- Right Handed
- Single, Left Hemisphere Cerebrovascular Stroke
- Must be at least 6 months poststroke onset
- Native Speaker of English
- Clinical Diagnosis of Aphasia
Exclusion Criteria
- Intracranial metallic body from prior neurosurgical procedure
- Implanted metallic devices: pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit or ventriculoperitoneal shunt
- Past history of seizure within 1 year
- Pregnancy
- History of substance abuse within last 6 months
Data sourced from ClinicalTrials.gov (NCT00608582). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.