Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Phase 2 Completed N=42 Randomized Single-blind Treatment

Treatment of Mood and Marriage Study (TOMMS)

Major Depressive Disorder · Partner Relational Disorder (V61.10)
Source: ClinicalTrials.gov NCT00612807 ↗
Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Apr 2011
Primary outcomePrimary: Hamilton Depression Rating Scale (HDRS) — 17.86; 19.0; 5.00; 7.29 Score on HDRS — p=0.056

Summary

The primary goal of this study is to develop and test a depression-specific marital therapy tailored for use with older adult populations.

Outcome Measures

OutcomeResultp-value
PRIMARY
Hamilton Depression Rating Scale (HDRS)		 17.86; 19.0; 5.00; 7.29; 9.17; 8.14 0.056
PRIMARY
Dyadic Adjustment Scale (DAS)		 72.14; 84.43; 84.17; 92.27; 89.67; 91.07 0.32
SECONDARY
Frequency & Acceptability of Partner Behavior		 — —
SECONDARY
Conflict Tactics Scale		 — —
SECONDARY
SCID Mood Disorders		 — —
SECONDARY
Personal Assessment of Intimacy in Relationships		 — —
SECONDARY
Beck Anxiety Inventory		 — —

Eligibility Criteria

Inclusion Criteria

  • One partner must receive a clinical diagnosis of major depressive disorder based upon our assessment
  • Couples must be living together
  • Either partner must report marital distress or tension
  • Willing to take antidepressant medication and participate in weekly marital therapy and assessments
  • The depressed partner cannot be involved in any other psychosocial treatment
  • Score above 24 on the Mini Mental Status Exam

Exclusion Criteria

  • Both partners meet diagnostic criteria for major depressive disorder based on our evaluation
  • Coexisting bipolar or psychotic disorder
  • Evidence of a primary substance abuse or dependence disorder
  • Current ECT treatment
  • Evidence of active and severe domestic violence
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00612807). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

Back to search