Phase 2
N=31
PRO 140 by IV Administration in Adults With HIV-1 Infection
HIV Infections
Bottom Line
View on ClinicalTrials.gov: NCT00613379 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
May 2013
Primary outcome: Primary: Maximum Change in Viral Load Following Initiation of Treatment. — -1.67; -1.83; -0.32 Log10copies HIV-1 RNA/mL
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- PRO 140 (Drug); Placebo (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- CytoDyn, Inc.
- Primary completion
- Aug 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maximum Change in Viral Load Following Initiation of Treatment. |
-1.67; -1.83; -0.32 | — |
Summary
The purpose of this study is:
1. To assess and characterize the PK and PD of PRO 140 administered IV
2. To assess the antiviral activity of PRO 140
3. To assess the safety and tolerability of PRO 140
Eligibility Criteria
Inclusion Criteria
- Males & females, age ≥ 18 years (or minimum adult age as determined by local regulatory authorities)
- Screening plasma HIV-1 RNA ≥ 5, 000 copies/mL
- CD4+ T-lymphocyte cell count ≥ 300 cells/mm3 and no documented count < or = 250 cells/mm3
- Has not taken any anti-retroviral therapy (ART) w/in 12 wks of Early Screening Visit
- Exclusive CCR5-tropic virus as determined by Trofile™ Assay at Early Screening Visit
- Clinically normal or "not clinically significant (NCS)" resting electrocardiogram
- Women of reproductive potential must have a negative serum pregnancy test at Late Screening Visit & a negative urine pregnancy test w/in 72 hrs prior to first dose of study medication, & be non-lactating. Male & female subjects must agree not to participate in a conception process from Early Screening Visit through Day 59.
Exclusion Criteria
- CXCR4 tropic virus or dual/mixed tropic (R5X4) virus determined by the Trofile™ Assay.
- Females who are pregnant, lactating or breastfeeding, or who plan to become pregnant during the study.
- History of active hepatitis within the previous 24 wks
- Prior use of any entry, attachment, CCR5 co-receptor or fusion inhibitor, experimental or approved.
Data sourced from ClinicalTrials.gov (NCT00613379). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.