Early Phase 1
Completed N=87
Nicotine Patch Pretreatment for Smoking Cessation in PTSD
Stress Disorders, Posttraumatic · Tobacco Use Disorder
Source: ClinicalTrials.gov NCT00625131 ↗
Enrolled (actual)
87
Serious AEs
2.4%
Results posted
Nov 2014
Primary outcomePrimary: Smoking Abstinence, Self-reported — 5; 11 participants
Summary
This study seeks to evaluate the relationship between PTSD, abstinence, and factors associated with relapse in the context of a randomized, clinical smoking cessation trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Smoking Abstinence, Self-reported |
5; 11 | — |
| SECONDARY Carbon Monoxide Monitoring |
8; 5 | — |
| SECONDARY Smoking Craving |
2.48; 2.59 | — |
Eligibility Criteria
Inclusion Criteria
- Smokers who smoke 10 or more cigarettes per day in the past year;
- 18-80 years old;
- English speakers;
- medically stable;
- stable on current medication regimen
Exclusion Criteria
- Pregnant women excluded;
- participants with organic mental disorder, schizophrenia, bipolar disorder, lifetime but not current PTSD, current substance abuse or dependence;
- medical conditions contraindicated with nicotine replacement therapy;
- use other forms of nicotine (cigars, nicotine gum, etc.)
Data sourced from ClinicalTrials.gov (NCT00625131). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.