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Home › Conditions › Tobacco Use

Tobacco Use

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Tobacco Use

159 trials tracked for Tobacco Use: 18 in phase 3 or 4 and 9 with published results. The most-cited published study has 134 citations.

159Trials tracked
18Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 4 12 Phase 3 6 Phase 2 38 Phase 1 12 Other / NA 91
  1. Phase 3 Pharmacogenetics, Emotional Reactivity and Smoking Completed · 134 cited
  2. Phase 4 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking Completed · 112 cited
  3. Phase 4 Varenicline Effects In Schizophrenic Smokers Completed · 106 cited
  4. Phase 4 Varenicline and Combined NRT for Smoking Cessation Completed · 72 cited
  5. Phase 3 Optimizing Tobacco Dependence Treatment in the Emergency Department Completed · 42 cited
  6. Phase 4 Bupropion for Smoking Cessation During Pregnancy Completed · 33 cited
Show 44 more trials
  1. Phase 3 Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers Completed · 30 cited
  2. Phase 3 Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day Completed · 8 cited
  3. Phase 4 Cannabis and Tobacco Co-use Study Completed · 3 cited
  4. Phase 4 Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers Completed
  5. Phase 4 Minocycline and Tobacco Craving in Smokers With Schizophrenia Completed
  6. Phase 4 Tobacco Cessation Treatment Preferences Among Veteran Smokers Completed
  7. Phase 4 Bupropion and Weight Control for Smoking Cessation - 1 Completed
  8. Phase 4 Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts Completed
  9. Phase 4 Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence Completed
  10. Phase 4 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed
  11. Phase 3 Chantix & Bupropion for Smoking Cessation Completed
  12. Phase 3 Maintaining Nonsmoking: Older Smokers - 1 Completed
  13. Phase 2 Effectiveness of Bupropion for Treating Nicotine Dependence in Young People Completed
  14. Phase 2 Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers Completed
  15. Phase 2 Efficacy of Varenicline in Ambivalent Smokers Completed
  16. Phase 2 Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) Completed
  17. Phase 2 Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia Completed
  18. Phase 2 Effect of Ramelteon on Smoking Abstinence Completed
  19. Phase 2 Treatment of Smoking Among Individuals With PTSD Completed
  20. Phase 2 Bupropion in Helping Adults Stop Smoking Completed
  21. Phase 2 Selegiline Patch for Treatment of Nicotine Dependence Completed
  22. Phase 2 N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers Completed
  23. Phase 2 Comparing Smoking Treatment Programs for Lighter Smokers - 1 Completed
  24. Phase 2 Efficacy of Varenicline for Smokeless Tobacco Use in India Completed
  25. Phase 2 Effect of Galantamine on Short-term Abstinence Completed
  26. Phase 2 Gabapentin for Smoking Cessation Completed
  27. Phase 2 Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers Completed
  28. Phase 2 Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers Completed
  29. Phase 2 Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders Completed
  30. Phase 2 Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women Completed
  31. Phase 2 Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules Completed
  32. Phase 2 Progesterone for Smoking Relapse Prevention Following Delivery Completed
  33. Phase 2 Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking Completed
  34. Phase 2 Intermittent or Continuous Acetylsalicylic Acid and Gene Expression in the Nasal Tissue of Current Smokers Completed
  35. Phase 2 Lorcaserin for Preventing Weight Gain Among Smokers Completed
  36. Phase 2 Innovative Interventions for Smoking Cessation Completed
  37. Phase 2 The Study of AZD8529 for Smoking Cessation in Female Smokers Completed
  38. Phase 2 Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder Completed
  39. Phase 2 Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia Completed
  40. Phase 2 Sulindac in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia Completed
  41. Phase 2 Improving Smoking Cessation Outcomes in Heavy Drinkers - 1 Completed
  42. Phase 2 Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders Completed
  43. Phase 2 Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use Completed
  44. Phase 2 Neural Substrates in Nicotine Withdrawal Completed

Showing the 50 most-cited and recently-updated of 159 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Mini review notes elevated substance use in sexual minority women compared to heterosexual women
Psychiatry Sys. Review
Mini review notes elevated substance use in sexual minority women compared to heterosexual women Substance use is higher among sexual minority women than heterosexual women
This narrative mini review examines substance use patterns in sexual minority women (SMW) versus heterosexual women. The authors synthesize …
A review shows substance use is more common among sexual minority women. Bisexual women face the highest risk. This review highlights the ne…
Frontiers May 7, 2026
Digital smoking cessation intervention for psychiatric inpatients shows preliminary abstinence benefits postdischarge
Primary Care & Family Medicine RCT
Digital smoking cessation intervention for psychiatric inpatients shows preliminary abstinence benefits postdischarge Digital tool helps psychiatric patients quit smoking after hospital
This randomized pilot trial enrolled 58 psychiatric inpatients who were tobacco users.
A new digital program helps psychiatric patients stay off cigarettes after leaving the hospital, when support usually drops off and relapse …
May 1, 2026
Surgeon General concludes causal link between movie smoking depictions and youth smoking initiation
Infectious Disease
Surgeon General concludes causal link between movie smoking depictions and youth smoking initiation Do movies make kids start smoking? The Surgeon General says yes
The U.S. Surgeon General has concluded there is a causal relationship between depictions of smoking in movies and smoking initiation among y…
The Surgeon General confirms that smoking scenes in movies directly cause young people to start smoking themselves.
CDC Apr 6, 2026
Gaps exist in tobacco-free policies and cessation treatment availability at US behavioral health facilities
Infectious Disease
Gaps exist in tobacco-free policies and cessation treatment availability at US behavioral health facilities Are mental health facilities helping people quit smoking? Gaps exist
An observational report of behavioral health treatment facilities in the United States found gaps in tobacco-free policies and the availabil…
Behavioral health facilities often lack tobacco-free policies and quit-smoking treatments, leaving patients without essential support to sto…
CDC Apr 4, 2026
School-based resilience interventions reduce adolescent tobacco, alcohol, and illicit substance use
Pediatrics Meta-analysis
School-based resilience interventions reduce adolescent tobacco, alcohol, and illicit substance use School resilience programs linked to lower substance use in students
A meta-analysis of school-based studies in students aged 6-18 years found resilience interventions were associated with reduced substance us…
School resilience programs that teach coping skills are linked to lower tobacco, alcohol, and drug use among students aged 6 to 18.
Apr 2, 2026

Questions about Tobacco Use

Do sexual minority women have higher tobacco use rates than heterosexual women?

Research consistently shows that sexual minority women have higher rates of tobacco use than heterosexual women, with bisexual women often facing the highest risk.

Full answer →
What methods do U.S. adults use to quit smoking based on the report?

U.S. adults use a mix of medications like nicotine replacement therapy and counseling, as well as behavioral methods like stopping cold turkey or cutting down, to quit smoking.

Full answer →