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Home › Conditions › Tobacco Use

Tobacco Use

12 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Tobacco Use

159 trials tracked for Tobacco Use: 18 in phase 3 or 4 and 9 with published results. The most-cited published study has 137 citations.

159Trials tracked
18Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 4 12 Phase 3 6 Phase 2 38 Phase 1 12 Other / NA 91
  1. Phase 3 Pharmacogenetics, Emotional Reactivity and Smoking Completed · 137 cited
  2. Phase 4 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking Completed · 113 cited
  3. Phase 4 Varenicline Effects In Schizophrenic Smokers Completed · 106 cited
  4. Phase 4 Varenicline and Combined NRT for Smoking Cessation Completed · 78 cited
  5. Phase 3 Optimizing Tobacco Dependence Treatment in the Emergency Department Completed · 42 cited
  6. Phase 4 Bupropion for Smoking Cessation During Pregnancy Completed · 35 cited
Show 44 more trials
  1. Phase 3 Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers Completed · 30 cited
  2. Phase 3 Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day Completed · 8 cited
  3. Phase 4 Cannabis and Tobacco Co-use Study Completed · 3 cited
  4. Phase 4 Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers Completed
  5. Phase 4 Minocycline and Tobacco Craving in Smokers With Schizophrenia Completed
  6. Phase 4 Tobacco Cessation Treatment Preferences Among Veteran Smokers Completed
  7. Phase 4 Bupropion and Weight Control for Smoking Cessation - 1 Completed
  8. Phase 4 Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts Completed
  9. Phase 4 Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence Completed
  10. Phase 4 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed
  11. Phase 3 Chantix & Bupropion for Smoking Cessation Completed
  12. Phase 3 Maintaining Nonsmoking: Older Smokers - 1 Completed
  13. Phase 2 Effectiveness of Bupropion for Treating Nicotine Dependence in Young People Completed
  14. Phase 2 Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers Completed
  15. Phase 2 Efficacy of Varenicline in Ambivalent Smokers Completed
  16. Phase 2 Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) Completed
  17. Phase 2 Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia Completed
  18. Phase 2 Effect of Ramelteon on Smoking Abstinence Completed
  19. Phase 2 Treatment of Smoking Among Individuals With PTSD Completed
  20. Phase 2 Bupropion in Helping Adults Stop Smoking Completed
  21. Phase 2 Selegiline Patch for Treatment of Nicotine Dependence Completed
  22. Phase 2 N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers Completed
  23. Phase 2 Comparing Smoking Treatment Programs for Lighter Smokers - 1 Completed
  24. Phase 2 Efficacy of Varenicline for Smokeless Tobacco Use in India Completed
  25. Phase 2 Effect of Galantamine on Short-term Abstinence Completed
  26. Phase 2 Gabapentin for Smoking Cessation Completed
  27. Phase 2 Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers Completed
  28. Phase 2 Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers Completed
  29. Phase 2 Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders Completed
  30. Phase 2 Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women Completed
  31. Phase 2 Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules Completed
  32. Phase 2 Progesterone for Smoking Relapse Prevention Following Delivery Completed
  33. Phase 2 Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking Completed
  34. Phase 2 Intermittent or Continuous Acetylsalicylic Acid and Gene Expression in the Nasal Tissue of Current Smokers Completed
  35. Phase 2 Lorcaserin for Preventing Weight Gain Among Smokers Completed
  36. Phase 2 Innovative Interventions for Smoking Cessation Completed
  37. Phase 2 The Study of AZD8529 for Smoking Cessation in Female Smokers Completed
  38. Phase 2 Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder Completed
  39. Phase 2 Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia Completed
  40. Phase 2 Sulindac in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia Completed
  41. Phase 2 Improving Smoking Cessation Outcomes in Heavy Drinkers - 1 Completed
  42. Phase 2 Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders Completed
  43. Phase 2 Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use Completed
  44. Phase 2 Neural Substrates in Nicotine Withdrawal Completed

Showing the 50 most-cited and recently-updated of 159 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Tobacco Use: what the trials found

Pharmacological interventions for smoking cessation show varying evidence. Bupropion demonstrated statistically significant results in smoking abstinence across multiple trials [14, 15], though specific outcomes regarding genetic markers (e.g., CYP2B6) and metabolic differences were noted 7. Varenicline was also evaluated as a primary intervention [8, 10].

Nicotine replacement therapies (NRT), including patches 13 and lozenges 17, have been studied for abstinence. While some trials showed significant results for nicotine lozenges 17, other NRT studies did not reach statistical significance in point prevalence or sustained abstinence 20. Combination therapies, such as Nicotine polacrilex combined with Bupropion, were also investigated 22.

Behavioral and specialized interventions include self-determination programs for tobacco dependence 16 and personalized pharmacotherapy 11. Other specific treatments explored include minocycline 12 and the use of very low nicotine content (VLNC) cigarettes combined with NRT 21.

Recent results — preliminary, needs further review

  • * Studies are investigating various products including 'Product A' 3, flavored/unflavored little cigars 4, and cigarettes with added sucrose 6. * Emerging data on specific devices like the Ploom HTP Menthol HTS and MX3 show significant differences in biomarkers such as NNAL, NNN, and 2-MHBMA 2. * Brief behavioral counseling was evaluated as a standalone intervention 5.

For the clinician treating this condition

  • Bupropion is supported by multiple trials for achieving smoking abstinence [14, 15].
  • Nicotine replacement therapies (NRT) show mixed results; while lozenges showed some efficacy in specific cohorts 17, other NRT studies did not reach statistical significance 20.
  • Varenicline and combination therapies (e.g., Nicotine polacrilex with Bupropion) are established options for clinical consideration [8, 10, 22].

AI synthesis of 14 cited trials, updated Jun 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Digitally augmented intervention increases 6-month abstinence from health-risk behaviors by RR 1.51
Primary Care & Family Medicine RCT
Digitally augmented intervention increases 6-month abstinence from health-risk behaviors by RR 1.51 Text Messages After ER Visit Cut Risky Habits
This randomized controlled trial of 572 adults in an emergency department found that a digitally augmented, theory-based intervention signif…
A 6-month program of phone advice plus weekly messages helped more ER patients cut back on smoking, drinking, or inactivity.
Sep 12, 2026
Nicotine electronic cigarettes increase quit rates compared to nicotine replacement therapy and behavioral support
Oncology Sys. Review
Nicotine electronic cigarettes increase quit rates compared to nicotine replacement therapy and behavioral support Nicotine electronic cigarettes show higher quit rates than traditional methods
This systematic review of 80 RCTs involving 29,861 participants found that nicotine electronic cigarettes (EC) significantly increased quit …
New data shows people using nicotine-containing electronic cigarettes are more likely to quit smoking compared to those using standard repla…
Cochrane Aug 27, 2026
Smokerface-Poster campaign shows lower increase in smoking prevalence with NNT of 93
Pediatrics RCT
Smokerface-Poster campaign shows lower increase in smoking prevalence with NNT of 93 Poster campaign may curb teen smoking, but results uncertain
This cluster-randomized controlled trial involving 9797 grade 6/7 students in German schools evaluated a low-intensity, appearance-based pos…
A low-cost poster campaign in German schools may slow teen smoking, but the effect wasn't statistically significant.
Aug 26, 2026
HMA plus NRT protocol aims to reduce nicotine craving and boost abstinence in TUD
Primary Care & Family Medicine RCT
HMA plus NRT protocol aims to reduce nicotine craving and boost abstinence in TUD New Trial to Test Acupuncture for Smoking Cessation
This randomized controlled trial protocol will compare harmonizing mind acupuncture plus nicotine replacement therapy against nicotine repla…
A new trial will test if adding acupuncture to nicotine patches helps people quit smoking and curb cravings.
Frontiers Aug 7, 2026
Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users
Pulmonology & Critical Care RCT
Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users Early Assessment May Improve Success Rates for Quitting Smoking
This randomized controlled trial of 636 daily smokers eligible for lung cancer screening found that a 4-week assessment interval was associa…
Checking progress at 4 weeks instead of 8 weeks may help people who smoke daily successfully quit using nicotine replacement therapy.
Jul 24, 2026
Tobacco and nicotine product use among Saudi adolescents varies significantly by study type and region
Primary Care & Family Medicine Meta-analysis
Tobacco and nicotine product use among Saudi adolescents varies significantly by study type and region New data reveals high nicotine use among Saudi adolescents
This systematic review synthesizes data on tobacco and emerging nicotine product use among Saudi adolescents aged 10 to 19 years. Findings i…
Recent findings show significant rates of cigarette, shisha, and e-cigarette use among teenagers in Saudi Arabia.
Frontiers Jul 7, 2026
Prevention interventions may reduce e-cigarette ever use while cessation-focused efforts likely reduce current adolescent usage
Gastroenterology Sys. Review
Prevention interventions may reduce e-cigarette ever use while cessation-focused efforts likely reduce current adolescent usage Interventions May Help Reduce E-Cigarette Use in Young People
This systematic review analyzed 10,510 participants across three studies to evaluate interventions for preventing or ceasing e-cigarette use…
Specific programs may help prevent children from starting e-cigarettes or help teenagers who already use them to quit.
Cochrane Jul 3, 2026
Mini review notes elevated substance use in sexual minority women compared to heterosexual women
Psychiatry Sys. Review
Mini review notes elevated substance use in sexual minority women compared to heterosexual women Substance use is higher among sexual minority women than heterosexual women
This narrative mini review examines substance use patterns in sexual minority women (SMW) versus heterosexual women. The authors synthesize …
A review shows substance use is more common among sexual minority women. Bisexual women face the highest risk. This review highlights the ne…
Frontiers May 7, 2026
Digital smoking cessation intervention for psychiatric inpatients shows preliminary abstinence benefits postdischarge
Primary Care & Family Medicine RCT
Digital smoking cessation intervention for psychiatric inpatients shows preliminary abstinence benefits postdischarge Digital tool helps psychiatric patients quit smoking after hospital
This randomized pilot trial enrolled 58 psychiatric inpatients who were tobacco users.
A new digital program helps psychiatric patients stay off cigarettes after leaving the hospital, when support usually drops off and relapse …
May 1, 2026
Surgeon General concludes causal link between movie smoking depictions and youth smoking initiation
Infectious Disease
Surgeon General concludes causal link between movie smoking depictions and youth smoking initiation Do movies make kids start smoking? The Surgeon General says yes
The U.S. Surgeon General has concluded there is a causal relationship between depictions of smoking in movies and smoking initiation among y…
The Surgeon General confirms that smoking scenes in movies directly cause young people to start smoking themselves.
CDC Apr 6, 2026
Gaps exist in tobacco-free policies and cessation treatment availability at US behavioral health facilities
Infectious Disease
Gaps exist in tobacco-free policies and cessation treatment availability at US behavioral health facilities Are mental health facilities helping people quit smoking? Gaps exist
An observational report of behavioral health treatment facilities in the United States found gaps in tobacco-free policies and the availabil…
Behavioral health facilities often lack tobacco-free policies and quit-smoking treatments, leaving patients without essential support to sto…
CDC Apr 4, 2026
School-based resilience interventions reduce adolescent tobacco, alcohol, and illicit substance use
Pediatrics Meta-analysis
School-based resilience interventions reduce adolescent tobacco, alcohol, and illicit substance use School resilience programs linked to lower substance use in students
A meta-analysis of school-based studies in students aged 6-18 years found resilience interventions were associated with reduced substance us…
School resilience programs that teach coping skills are linked to lower tobacco, alcohol, and drug use among students aged 6 to 18.
Apr 2, 2026

Questions about Tobacco Use

Do sexual minority women have higher tobacco use rates than heterosexual women?

Research consistently shows that sexual minority women have higher rates of tobacco use than heterosexual women, with bisexual women often facing the highest risk.

Full answer →
What methods do U.S. adults use to quit smoking based on the report?

U.S. adults use a mix of medications like nicotine replacement therapy and counseling, as well as behavioral methods like stopping cold turkey or cutting down, to quit smoking.

Full answer →