Phase 4
Completed N=258
CAMEO: Canadian Methotrexate and Etanercept Outcome Study
Source: ClinicalTrials.gov NCT00654368 ↗Enrolled (actual)
258
Serious AEs
13.6%
Results posted
Jun 2014
Primary outcomePrimary: Change From Month 6 to Month 12 in Disease Activity Sscore 28 (DAS28) — -0.39; 0.02 scores on a scale
Summary
The purpose of the study is to evaluate the use of etanercept in the treatment of rheumatoid arthritis with or without methotrexate treatment over a 24 month period
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Month 6 to Month 12 in Disease Activity Sscore 28 (DAS28) |
-0.39; 0.02 | — |
| SECONDARY Disease Activity Score (DAS) 28 Response |
30.5; 25.7; 16.8; 19.0; 41.1; 41.9 | — |
| SECONDARY Change From Baseline in Disease Activity Score 28 (DAS28) |
1.97; 1.97; 1.43; 1.91; 1.35; 2.01 | — |
| SECONDARY Drug Persistence |
100; 100; 93.2; 87.6; 81.9; 78.8 | — |
| SECONDARY Change From Baseline in Modified Total Sharp Score (mTSS) |
0.3; 0.1; 0.4; 0.0 | — |
| SECONDARY Change From Baseline in Joint Erosion Score |
0.0; 0.0; 0.1; 0.0 | — |
| SECONDARY Change From Baseline in Joint Space Narrowing |
0.2; 0.1; 0.3; -0.0 | — |
| SECONDARY Change From Month 6 in Health Assessment Questionnaire Disability Index (HAQ DI) |
0.148; 0.026; 0.179; -0.004; 0.198; 0.016 | — |
| SECONDARY Change From Month 6 in Health Assessment Questionnaire Pain Visual Analog Scale (VAS) |
7.3; 2.4; 8.0; 1.8; 8.7; 5.1 | — |
| SECONDARY Change From Month 6 in Short Form 36 Health Survey (SF-36) |
-1.74; -0.30; -3.28; -0.10; -3.08; -0.75 | — |
| SECONDARY Change From Month 6 in Work Productivity and Activity Impairment (WPAI) |
-4.2; -0.3; -5.5; 0.9; -3.8; -0.1 | — |
| SECONDARY Change From Month 6 in Treatment Satisfaction Questionnaire for Medication (TSQM) |
-5.0; -1.2; -7.4; -1.1; -5.0; -1.5 | — |
| SECONDARY Number of Participants With Adverse Events (AEs) |
86; 92; 11; 17; 9; 6 | — |
Eligibility Criteria
Inclusion Criteria
- 18 years of age or older at the baseline visit
- An American College of Rheumatology(ACR) diagnosis of rheumatoid arthritis with onset of symptoms of at least 6 months
- Active disease of at least 3 swollen joints from the Disease Activity Severity 28 at the baseline visit
- A Disease Activity Severity 28 score of ≥ 3.2 at the baseline visit
- Have not previously received etanercept therapy
- Able to start etanercept therapy per the approved product monograph
- Able to continue methotrexate therapy per the approved product monograph and have received a dose of at least 15 mg/wk (or 10 mg/wk in the case of documented intolerance to higher doses) for at least 12 weeks and this dose has been stable at least 4 weeks before the baseline visit
- The patient or legally acceptable representative must provide written informed consent for participation in the study before any study specific procedures are performed
Exclusion Criteria
- Patients who have a positive purified protein derivative (PPD) skin test and who do not have a documented course of anti-tuberculosis therapy. Patients with a positive PPD skin test (equal to or greater than 5 mm), a negative chest x-ray at screening which should be repeated if indicated during of the study, at low risk based on exposure and travel and have initiated a course of anti-tuberculosis therapy of which at least 8 weeks have been completed would be eligible for the study. The full course of anti-tuberculosis therapy must be completed
- Patients who have previously received infliximab or adalimumab
- Active infections within 2 weeks of the baseline visit or during the study period
- Any history of human immunodeficiency (HIV) infection, untreated tuberculosis, multiple sclerosis, congestive heart failure, hepatitis B, hepatitis C, cytopenia, prior or current use of cyclophosphamide or malignancy (other than basal cell carcinoma or squamous cell carcinoma of the skin, or in situ carcinoma of the cervix) in the past 5 years
- Women who are pregnant or lactating or of childbearing potential who are not using adequate contraception
- Receipt of any investigational therapy within 4 weeks of the initiation of study medication or during the study period
- Presence of any significant and uncontrolled medical condition, which in the investigator's opinion precludes the use of etanercept, as outlined in the product monograph
- Participants not available for follow-up assessment or unable to comply with study procedures
Data sourced from ClinicalTrials.gov (NCT00654368). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.