Risk-optimized use of Janus kinase inhibitors in Japanese patients with rheumatoid arthritis depends on comorbidities
New evidence helps doctors choose safer arthritis treatments for seniors
This narrative review examines the safety and risk profile of Janus kinase inhibitors (JAKi) for rheumatoid arthritis specifically within th…
Doctors are moving toward personalized plans for rheumatoid arthritis, focusing on a patient's specific health risks rather than just their …
Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
Stress hormones may harm bone growth in children with inflammatory conditions
This narrative review synthesizes evidence from animal models and pediatric inflammatory disorders showing that stress-induced IL-6 upregula…
A review suggests stress-induced IL-6 upregulation impairs skeletal growth and bone health in kids with inflammatory disorders, highlighting…
Short-term prednisolone bridging enables 95% discontinuation in new rheumatoid arthritis patients after 24 months
Most patients stop steroid use after a short bridge to methotrexate treatment
This randomized controlled trial enrolled 230 patients with newly diagnosed rheumatoid arthritis naive to disease-modifying antirheumatic dr…
A trial of 230 patients with new rheumatoid arthritis found that most could stop using prednisolone after just seven weeks of short-term bri…
Biologic and targeted synthetic DMARDs show reassuring malignancy safety in inflammatory arthritides, but non-melanoma skin cancer risk rises with TNF inhibitors
Biologics for arthritis: Cancer risk appears low overall
This narrative review of biologic and targeted synthetic DMARDs in immune-mediated inflammatory arthritides finds most therapies have reassu…
Most biologic arthritis drugs don't raise overall cancer risk, but skin cancer risk may be higher with some.
Meta-analysis finds rheumatoid arthritis associated with increased thyroid cancer risk in pooled cohort data
People with rheumatoid arthritis might have a higher chance of developing thyroid cancer in some groups
This meta-analysis of cohort studies involving 1,970,165 participants found a higher risk of thyroid cancer in rheumatoid arthritis patients…
A large review of nearly two million people found that those with rheumatoid arthritis could have a higher risk of thyroid cancer. This risk…
Sleep problems affect 61% of adults with rheumatoid arthritis in WHO EMRO countries
Sleep troubles hit 60.9% of adults with rheumatoid arthritis in the Eastern Mediterranean
This systematic review and meta-analysis of 2,315 adults with rheumatoid arthritis in WHO EMRO countries found sleep-related problems are hi…
Sleep problems affect more than six out of ten adults with rheumatoid arthritis in the Eastern Mediterranean. Depression and pain are the st…
Microbiota-targeted interventions for elderly-onset rheumatoid arthritis remain an area requiring further investigation
New review looks at gut health fixes for older adults with rheumatoid arthritis
This narrative review examines microbiota-targeted interventions, including dietary modifications, nutraceuticals, and fecal microbiota tran…
A new narrative review explores how changing gut bacteria might help older adults manage rheumatoid arthritis symptoms.
CD38+ NK cells may link disrupted immune tolerance in rheumatoid arthritis and colorectal cancer
Immune cells linked to cancer and arthritis show unusual activity in early review
A narrative review synthesizes evidence on CD38+ NK cells in rheumatoid arthritis and colorectal cancer, finding increased proportions in pe…
A new look at immune cells shows they behave differently in people with rheumatoid arthritis and colorectal cancer. This early review highli…
Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis
Stopping arthritis drugs before surgery may raise flare risk
This living systematic review evaluates perioperative management of conventional synthetic DMARDs in adults with rheumatoid arthritis, psori…
Low-certainty evidence suggests stopping certain arthritis drugs before surgery might increase the chance of a disease flare, but infection …
Meta-analysis of upadacitinib for rheumatoid arthritis finds similar efficacy for 15 mg and 30 mg doses
Upadacitinib improves rheumatoid arthritis symptoms in meta-analysis
This systematic review and meta-analysis of 5,237 participants with rheumatoid arthritis found that upadacitinib 15 mg and 30 mg significant…
A new analysis finds upadacitinib helps rheumatoid arthritis symptoms, but higher dose raises infection risk.
Narrative review discusses CD40/CD40L signaling regulation in rheumatoid arthritis and other autoimmune conditions
Safer CD40/CD40L targeting needs selectivity for autoimmune diseases
This narrative review examines CD40/CD40L signaling regulation in rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome…
A narrative review suggests that safer therapeutic targeting of CD40/CD40L signaling will require greater selectivity to treat rheumatoid ar…
Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
A new enzyme target could treat many serious diseases at once
This narrative review synthesizes evidence on PAD4-mediated citrullination and PAD4-directed therapies for conditions including rheumatoid a…
A single enzyme called PAD4 helps cause many different diseases, and new medicines targeting it might finally help people with multiple cond…
Research across Arthritis
Related studies from across the Arthritis family.
Review of ruxolitinib for systemic juvenile arthritis with macrophage activation syndrome
Two children with severe arthritis found relief using a new drug approach
This narrative review synthesizes a retrospective case series and literature search on ruxolitinib for systemic juvenile idiopathic arthriti…
Two children with severe arthritis complications found relief using a new drug approach, offering hope for those who struggle with standard …
Telephone-delivered Walk With Ease program recruitment strategies compared in adults with arthritis
Radio ads and Facebook work best to recruit arthritis patients
This randomized trial in 267 adults with arthritis compared recruitment strategies for a telephone-delivered walking program. Facebook was t…
Radio ads and Facebook ads work best to get arthritis patients into walking programs, but the best method depends on who you are trying to r…
Ixekizumab shows efficacy in children with enthesitis-related and juvenile psoriatic arthritis
New drug ixekizumab shows promise for children with arthritis
This multicentre, open-label, phase 3 study evaluated ixekizumab in 101 children with enthesitis-related arthritis or juvenile psoriatic art…
A phase 3 study found ixekizumab helped many children with arthritis meet response criteria at week 16, with mostly mild side effects report…
Systematic review and meta-analysis supports adalimumab plus methotrexate for JIA-associated uveitis
Combination therapy reduces relapse risk in children with eye inflammation from arthritis
This systematic review and meta-analysis of RCTs evaluated adalimumab plus methotrexate in children with juvenile idiopathic arthritis-assoc…
Combining adalimumab with methotrexate lowers relapse risk and helps reduce steroid use in children with arthritis-related eye inflammation.
Baricitinib showed limited efficacy in pediatric JIA-uveitis patients refractory to methotrexate or biologics at week 24
New Hope for Kids with Stubborn Eye Inflammation
This open-label, active-controlled phase-3 multicenter trial enrolled 30 pediatric patients with juvenile idiopathic arthritis-associated uv…
A new drug shows early promise for children with stubborn eye inflammation who didn't respond to standard treatments, offering hope when oth…
Questions about Rheumatoid Arthritis
Did baricitinib work well for juvenile idiopathic arthritis eye inflammation?
Baricitinib showed limited effectiveness for treating eye inflammation in children with juvenile idiopathic arthritis who did not respond to other standard treatments.
Full answer →Can machine learning predict when juvenile idiopathic arthritis will go inactive?
Yes, machine learning models using registry data can predict inactive disease in juvenile idiopathic arthritis with about 70-76% accuracy, but they are not yet ready for routine clinical use.
Full answer →Can Hadlima be used to treat juvenile idiopathic arthritis?
Yes, Hadlima (adalimumab) is FDA-approved to treat moderately to severely active polyarticular juvenile idiopathic arthritis in patients aged 2 years and older.
Full answer →How does macrophage metabolism change in gouty arthritis patients?
In gouty arthritis, macrophages shift their energy use from oxidative phosphorylation to glycolysis and change from pro-inflammatory to anti-inflammatory states as the attack resolves.
Full answer →Does quercetin work for gouty arthritis based on recent reviews?
Recent reviews suggest quercetin has anti-inflammatory and antioxidant properties that could help with gout, but there is currently no strong clinical proof it works for gouty arthritis in humans.
Full answer →Why do current gouty arthritis models fail to match human disease?
Current gout models fail because they do not fully capture the complex metabolic changes in macrophages or the chronic, multi-factorial nature of human disease.
Full answer →How is Arthritis Awareness Month observed to highlight the condition's impact?
Arthritis Awareness Month is observed in May to bring attention to the condition and its impact on daily life.
Full answer →What percentage of U.S. adults with arthritis engage in physical activity?
About 67% of U.S. adults with arthritis engage in at least one type of physical activity, though many do not meet full health guidelines.
Full answer →All Rheumatoid Arthritis Articles
- Risk-optimized use of Janus kinase inhibitors in Japanese patients with rheumatoid arthritis depends on comorbidities
- Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
- Short-term prednisolone bridging enables 95% discontinuation in new rheumatoid arthritis patients after 24 months
- Biologic and targeted synthetic DMARDs show reassuring malignancy safety in inflammatory arthritides, but non-melanoma skin cancer risk rises with TNF inhibitors
- Meta-analysis finds rheumatoid arthritis associated with increased thyroid cancer risk in pooled cohort data
- Sleep problems affect 61% of adults with rheumatoid arthritis in WHO EMRO countries
- Microbiota-targeted interventions for elderly-onset rheumatoid arthritis remain an area requiring further investigation
- CD38+ NK cells may link disrupted immune tolerance in rheumatoid arthritis and colorectal cancer
- Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis
- Meta-analysis of upadacitinib for rheumatoid arthritis finds similar efficacy for 15 mg and 30 mg doses
- Narrative review discusses CD40/CD40L signaling regulation in rheumatoid arthritis and other autoimmune conditions
- Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
- Narrative review explores m6A modification and metabolic reprogramming in rheumatoid arthritis
- Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
- Narrative review on multi-omics for spondyloarthritis and psoriatic arthritis
- Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients
- Narrative review explores plant-derived extracellular vesicles for rheumatoid arthritis
- FDA Approves Hadlima (adalimumab) for Multiple Inflammatory Indications
- Telephone-delivered Walk With Ease program recruitment strategies compared in adults with arthritis
- Meta-analysis of 38 rodent studies shows sinomenine reduces arthritis markers in preclinical models
- Psoriatic arthritis linked to interstitial lung disease prevalence
- Targeted therapies for psoriasis and psoriatic arthritis significantly alter lipid profiles across diverse patient populations
- Systematic review explores the role of RNA methylation in autoimmune rheumatic diseases
- Narrative review of transposable element methylation in autoimmune diseases
- Team-based care with rheumatological specialist assistants improved patient satisfaction in seropositive rheumatoid arthritis flares
- Systematic review and meta-analysis of diagnostic algorithms for rheumatoid arthritis and juvenile idiopathic arthritis
- High-intensity exercise improves strength and aerobic capacity in rheumatoid arthritis patients compared to low-intensity exercise
- Late-onset rheumatoid arthritis shows higher DAS28 scores and lower remission rates compared to young-onset disease in a meta-analysis
- Systematic review and meta-analysis of supervised exercise for foot pain in rheumatoid arthritis
- Systematic review and meta-analysis supports adalimumab plus methotrexate for JIA-associated uveitis
- Ixekizumab shows efficacy in children with enthesitis-related and juvenile psoriatic arthritis
- GWAS and Mendelian randomization link aging, rheumatoid arthritis, and herpes zoster via shared MHC signals
- Narrative review on macrophage metabolism in gouty arthritis and therapeutic gaps
- Nomogram Predicts Osteoporosis Risk in Rheumatoid Arthritis Patients
- Combined MSK US and machine learning model improves rheumatoid arthritis disease activity assessment
- Etanercept therapy alters monocyte subsets and improves DAS28-CRP in rheumatoid arthritis patients
- Multi-ancestral GWAS identifies 152 RA loci with improved polygenic risk scores for AFR and AMR populations
- Meta-analysis identifies genetic variants linked to inflammatory pathways in rheumatoid arthritis and axial spondyloarthritis
- Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions
- Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations
- Secukinumab improves skin response in Chinese patients with psoriatic arthritis
- Longitudinal ANA dynamics predict 12-month remission in 688 adults with rheumatoid arthritis
- Autoimmune Thyroiditis Prevalence Higher in Obese Women With PCOS in Retrospective Cohort Analysis
- Biological and clinical factors associated with peripheral neuropathy in rheumatoid arthritis cohort
- Machine learning models predict inactive disease in juvenile idiopathic arthritis using registry data
- FDA Approves Stelara (ustekinumab) for moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis
- FDA Approves Stelara (ustekinumab) for moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis
- Narrative review discusses transcriptomics and algorithms in rheumatoid arthritis care
- Narrative review explores multimodal approaches for autoimmune diseases including rheumatoid arthritis and Crohn's
- Baricitinib showed limited efficacy in pediatric JIA-uveitis patients refractory to methotrexate or biologics at week 24
- Systematic review examines IL-35 and IL-39 roles in rheumatoid arthritis pathophysiology and therapeutic potential
- Guselkumab Phase III trials validate 3VAS and 4VAS measures for psoriatic arthritis disease activity assessment
- Hospitalized AE-RA-ILD patients receiving JAK inhibitors alongside glucocorticoids showed mixed respiratory outcomes over three months
- Systematic review and meta-analysis finds CEUS comparable to MRI for synovitis detection
- Case report suggests grade 3 ICI-induced inflammatory arthritis may correlate with sustained response to tislelizumab in advanced head and neck carcinoma
- Natural and synthetic compounds suppress inflammasome activation in NLRP3-driven pathologies
- Systematic review of gouty arthritis models highlights limitations in reproducing human disease complexity
- Implementation of cliexa-RA digital platform improved patient experience and time efficiency for 300 rheumatoid arthritis patients
- Systematic review examines lipid-immune crosstalk and dyslipidemia in rheumatoid arthritis patients
- Review of quercetin in metabolic diseases shows promise but lacks clinical validation
- Systematic review links gut microbiota dysbiosis to CKD-MBD, RA, OA, and OP pathogenesis
- Interstitial lung disease reduces achievement of rheumatoid arthritis treatment goals over 24 months
- Biological DMARDs show marginal patient-reported outcome benefits over conventional therapy in early rheumatoid arthritis
- Hand massage improves grip strength and function in early RA patients in pilot trial
- Post-hoc analysis of RCTs and cohorts identifies predictors of remission in ACPA-positive early RA treated with abatacept plus methotrexate or methotrexate alone
- Cross-sectional study finds association between autoimmune thyroiditis and rheumatoid arthritis
- Phase 2 trial finds hydroxychloroquine does not prevent rheumatoid arthritis in at-risk individuals
- Occupational inhalant exposures associated with increased rheumatoid arthritis risk in meta-analysis
- Meta-analysis compares HAQ-DI, SF36-PF, and SF36-PCS for physical function in psoriatic arthritis trials
- Rheumatoid arthritis is associated with a 58% higher risk of COPD compared to the general population
- FPGS Gene Variants Linked to Methotrexate Efficacy and Toxicity in Rheumatoid Arthritis
- Reduced anti-CXCR3 antibodies associated with systemic autoimmunity and atherosclerosis in cohort study
- Meta-analysis finds oral JAK inhibitors increase HDL and LDL cholesterol levels in patients from RCTs
- Arthritis affects 22.7% of U.S. adults, projected to reach 78.4 million by 2040
- Immune signatures precede and accompany subclinical joint inflammation in ACPA-positive individuals at high risk for RA
- Arthritis Awareness Month observed in May to highlight condition impact
- Southeastern US states show highest arthritis-related severe joint pain and inactivity
- National prevalence of arthritis and associated activity limitations in U.S. adults examined
- Report describes physical activity patterns among US adults with arthritis
- Survey describes arthritis prevalence by age and sex among US adults
- Nurse counseling improves pain, fatigue, and function in rheumatoid arthritis patients in small RCT
- Review Links Gut Dysbiosis to Immune Dysfunction in Rheumatoid Arthritis
- Report examines arthritis diagnosis among U.S. veterans, specific numbers not provided
- Phenotype-based pain management in RA patients shows improved outcomes in retrospective cohort
- Elevated neutrophil-to-lymphocyte ratio correlates with higher mortality in rheumatoid arthritis
- Menopausal hormone therapy associated with modestly increased rheumatoid arthritis risk in meta-analysis
- Meta-analysis finds nausea in 24% and abdominal pain in 20% of RA patients on methotrexate