Phase 2
Completed N=50
Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest
Source: ClinicalTrials.gov NCT00676585 ↗Enrolled (actual)
50
Serious AEs
68.0%
Results posted
May 2017
Primary outcomePrimary: Time to Shock Reversal — 55; 49 hours
Summary
The major goal of this project is to determine whether the use of physiologic doses of corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and alters microcirculatory flow in post-cardiac arrest patients.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time to Shock Reversal |
55; 49 | — |
| SECONDARY Mortality |
16; 18 | — |
| SECONDARY Sub-group Analysis of Patients With Adrenal Insufficiency |
1; 6; 0; 2; 0; 3 | — |
Eligibility Criteria
Inclusion Criteria
- Greater than 18 years old
- Either pre-hospital cardiac arrest and ROSC or Inpatient Cardiac Arrest with resultant ROSC
- Vasopressor dependent for a minimum of 1 hour post-arrest
Exclusion Criteria
- Pregnant
- Indication for Corticosteroids outside of current research proposal
- DNR or comfort care measures
- Presence of septic shock
- Chronic Use (>1week) of oral Corticosteroids in the last year
Data sourced from ClinicalTrials.gov (NCT00676585). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.