Phase 4
Completed N=120
High Dose Vitamin B1 to Reduce Abusive Alcohol Use
Alcoholism
Source: ClinicalTrials.gov NCT00680121 ↗
Enrolled (actual)
120
Serious AEs
0.0%
Results posted
Sep 2014
Primary outcomePrimary: Change in Average Daily Alcohol Consumption — -3.4; -3.0 alcoholic drinks per day
Summary
B1AS tests the hypothesis that increased vitamin B1 (thiamine) intake can repair brain systems damaged by alcohol and help people with alcohol problems control their alcohol use. A strong, man-made form of thiamine (Benfotiamine) is used to increase blood thiamine to much higher levels than can be achieved using normal vitamin supplements. Drinking patterns are examined over 6 months of continued supplement use. Men and women with a recent history of alcohol problems are eligible to participate.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Average Daily Alcohol Consumption |
-3.4; -3.0 | — |
| SECONDARY Alcoholism Severity Scale |
14.0; 10.7 | — |
| SECONDARY Barrett Impulsivity Scale: Total Impulsiveness |
65.0; 65.4 | — |
| SECONDARY Symptom Checklist-90 (SCL-90): Global Severity Index |
1.02; 1.04 | — |
Eligibility Criteria
Inclusion Criteria
- Problem drinking in the last 30 days
Exclusion Criteria
- Prolonged abstinence
- Serious medical problems
Data sourced from ClinicalTrials.gov (NCT00680121). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.