Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
N/A N=21 Treatment

Insulin and Polycystic Ovary Syndrome

PCOS

Bottom Line

View on ClinicalTrials.gov: NCT00683774 ↗
Enrolled (actual)
21
Serious AEs
0.0%
Results posted
Aug 2014
Primary outcome: Primary: Renal Clearance of D-chiroinositol (DCI) at 12 Days — 4.75; 5.16 ml/min

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
diazoxide (Drug)
Age
Adult · 18+ yrs
Sex
Female
Sponsor
Virginia Commonwealth University
Primary completion
Dec 2008

Outcome Measures

OutcomeResultp-value
PRIMARY
Renal Clearance of D-chiroinositol (DCI) at 12 Days		 4.75; 5.16 —
PRIMARY
Level of Circulating D-chiro Inositol (DCI)		 0.27; 0.27 —

Summary

Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women. This leads to a reduction in circulating DCI and insulin stimulated release of DCI-IPG.To determine if decreasing circulating insulin directly by inhibition of islet insulin release with diazoxide in obese women with PCOS 1)decreases the renal clearance of DCI and 2) increases the circulating concentration of DCI.

Eligibility Criteria

Inclusion Criteria

  • Obese women with PCOS and normal women aged 18-40,
  • PCOS less than 8 periods/year, elevated total or free testosterone, normal thyroid function tests and serum prolactin, exclusion of adrenal hyperplasia
  • Normal regular monthly periods, no clinical evidence of androgen excess,
  • All Acceptable health on interview, medical history, physical exams and lab tests, signed, witnessed informed consent and ability to comply to study requirements

Exclusion Criteria

  • DM, clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious, neoplastic or malignant disease.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00683774). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

Back to search