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Home › Conditions › Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

Part of Ovarian Cysts

35 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Polycystic Ovary Syndrome

64 trials tracked for Polycystic Ovary Syndrome: 27 in phase 3 or 4 and 13 with published results. The most-cited published study has 6076 citations.

64Trials tracked
27Phase 3 & 4
0Recruiting
13With published results
Phase distribution
Phase 4 10 Phase 3 17 Phase 2 11 Phase 1 4 Other / NA 22
  1. Phase 4 The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS Completed · 6,076 cited
  2. Phase 4 LIPT - Liraglutide in Polycystic Ovary Syndrome Completed · 171 cited
  3. Phase 3 Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS Completed · 162 cited
  4. Phase 4 The Effects of Vitamin D on Angiogenic Factors in Women With Polycystic Ovary Syndrome Completed · 114 cited
  5. Phase 4 Combined Letrozole and Clomid in Women With Infertility and PCOS Completed · 97 cited
  6. Phase 3 EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS) Completed · 96 cited
Show 44 more trials
  1. Phase 3 Liver and Fat Regulation in Overweight Adolescent Girls Completed · 85 cited
  2. Phase 4 Insulin Resistance, Polycystic Ovary Syndrome, and Bone Research Study Completed · 44 cited
  3. Phase 4 The Effect of Dipeptidyl Peptidase 4 Inhibition on Growth Hormone Secretion in Women With Polycystic Ovarian Syndrome Completed · 40 cited
  4. Phase 3 Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis Completed · 30 cited
  5. Phase 3 Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome Completed · 17 cited
  6. Phase 3 Comparing the Effects of Oral Contraceptive Pills Versus Metformin Completed · 2 cited
  7. Phase 3 Treating PCOS With Semaglutide vs Active Lifestyle Intervention Completed
  8. Phase 4 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed
  9. Phase 4 Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS Completed
  10. Phase 4 Continuous Versus Cyclical OCP Use in PCOS Completed
  11. Phase 4 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed
  12. Phase 3 Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS) Completed
  13. Phase 3 Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS) Completed
  14. Phase 3 Metabolic and Neuro-Endocrine Effect of Treating PCOS in Adolescents Completed
  15. Phase 3 The Effect of Vitamin D Supplementation Among Overweight Jordanian Women With Polycystic Ovary Syndrome (PCOS) Completed
  16. Phase 3 Pregnancy in Polycystic Ovary Syndrome II Completed
  17. Phase 3 Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy Completed
  18. Phase 3 Theca Cell Function in Women With Polycystic Ovary Syndrome (PCOS) Completed
  19. Phase 3 Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Completed
  20. Phase 3 Analysis of Two Therapeutic With Cetrotide® in Polycystic Ovarian (PCO) Women in Assisted Reproductive Technology (ART) Completed
  21. Phase 3 Treatment of Adolescent Polycystic Ovary Syndrome (PCOS) Completed
  22. Phase 2 Study of Pharmacodynamics of LIK066 in Overweight and Obese Women With Polycystic Ovary Syndrome Completed
  23. Phase 2 Study of the Safety and Efficacy of Elagolix in Women With Polycystic Ovary Syndrome Completed
  24. Phase 2 Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS) Completed
  25. Phase 2 The University of Michigan PCOS Intervention Using Nutritional Ketosis Completed
  26. Phase 2 Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women Completed
  27. Phase 2 Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction Completed
  28. Phase 2 Cavitation Ultrasound in Treatment of Patients With PCOS Completed
  29. Phase 2 Vitamin D for the Treatment of Women With Polycystic Ovary Syndrome (PCOS) Completed
  30. Phase 2 A Trial of Lipitor (Atorvastatin) for the Treatment of Polycystic Ovary Syndrome (PCOS) in Women With Elevated Low-density Lipoprotein (LDL) Cholesterol Completed
  31. Phase 2 The Efficacy and Safety Study of Tung's Acupuncture for Polycystic Ovarian Syndrome Completed
  32. Phase 2 Androgen Excess as a Cause for Adipogenic Dysfunction in PCOS Women Completed
  33. Phase 1 Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS Completed
  34. Phase 1 Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome Completed
  35. Phase 1 Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome Completed
  36. Phase 1 Determining How Quickly Progesterone Slows LH Pulse Frequency Completed
  37. N/A Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS Completed
  38. N/A Behavioral Economics for Activity Motivation in Adolescents (BEAM) Completed
  39. N/A Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS) Completed
  40. N/A Sex Steroids, Sleep, and Metabolic Dysfunction in Women Completed
  41. N/A Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH. Completed
  42. N/A Evaluation of Vitamin D in Women With PCOS and Sexual Dysfunction Completed
  43. N/A Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea Completed
  44. N/A Nimodipine to Prevent LH Surge During Ovulation Induction: Blinded Placebo-controlled RCT Completed

Showing the 50 most-cited and recently-updated of 64 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Polycystic Ovary Syndrome: what the trials found

Pharmacological management of PCOS involves several classes of agents with varying impacts on metabolic and reproductive markers. Clomiphene citrate has been shown to significantly increase the number of participants achieving ovulation as measured by mid-luteal progesterone 4, while also increasing the number of developing follicles 4 and the size of the largest developing follicle 4. However, another trial using clomiphene citrate did not show a statistically significant difference in ultrasound-detected ovulation or serum progesterone levels 15.

Metabolic interventions include Metformin XR, which significantly improved glucose metabolism 14, oral disposition index 14, and fasting glucose 14. Combination therapies such as OCP plus Metformin were evaluated for metabolic syndrome and changes in serum apolipoprotein B 16. GLP-1 receptor agonists and related agents showed significant effects on weight and insulin sensitivity; specifically, Liraglutide (Saxenda) was associated with significant reductions in absolute body weight 11 and BMI 11, while Exenatide once weekly significantly improved the oral disposition index and reduced both body weight and BMI 12.

Vitamin D3 supplementation has been linked to improvements in menstrual regularity and hirsutism scores 22. Specific hormonal treatments, such as 3 mg DRSP/20 μg EE, demonstrated a significant reduction in biochemical markers of hyperandrogenism 9 without significant changes to BMI or cardiometabolic measures 9. Menotropin was evaluated for fertility outcomes, showing high rates of oocyte fertilization and biochemical pregnancy 10.

For the clinician treating this condition

  • Clomiphene is associated with improved ovulation markers (follicle count, size, and progesterone levels), though results regarding ultrasound-detected ovulation are not consistent across trials.
  • Metformin XR provides significant improvements in glucose metabolism and fasting glucose levels.
  • GLP-1 receptor agonists like Liraglutide and Exenatide demonstrate significant efficacy in reducing BMI and body weight while improving insulin sensitivity markers.
  • Vitamin D3 supplementation is associated with improved menstrual regularity and reduced hirsutism scores.

AI synthesis of 9 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Electroacupuncture ranks highest for total efficacy in acupuncture interventions for polycystic ovary syndrome
Rheumatology Meta-analysis
Electroacupuncture ranks highest for total efficacy in acupuncture interventions for polycystic ovary syndrome Acupuncture Methods Show Varying Success for Polycystic Ovary Syndrome
This network meta-analysis of 92 randomized controlled trials evaluated various acupuncture-based interventions for polycystic ovary syndrom…
Different types of acupuncture treatments show varying levels of success in managing hormones and testosterone for people with PCOS.
Frontiers Jul 29, 2026
Higher AMH levels in PCOS patients correlate with higher oocyte yields and increased OHSS risk
Rheumatology Meta-analysis
Higher AMH levels in PCOS patients correlate with higher oocyte yields and increased OHSS risk AMH hormone levels impact pregnancy success for women with PCOS
This systematic review and meta-analysis of women with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) fo…
New data shows that specific hormone levels can signal different risks and success rates for women with PCOS undergoing fertility treatments…
Frontiers Jul 28, 2026
Women with Polycystic Ovary Syndrome have 24% prevalence of Gestational Diabetes Mellitus
Diabetes & Endocrinology Meta-analysis
Women with Polycystic Ovary Syndrome have 24% prevalence of Gestational Diabetes Mellitus Women with Polycystic Ovary Syndrome face higher risk of gestational diabetes
This systematic review and meta-analysis analyzed data from 5,507 women to determine the prevalence of Gestational Diabetes Mellitus in pati…
Women with Polycystic Ovary Syndrome (PCOS) have a significantly higher risk of developing gestational diabetes during pregnancy.
Frontiers Jul 17, 2026
Astaxanthin may serve as a potential adjuvant treatment for PCOS by addressing oxidative stress and inflammation
OB/GYN & Women's Health Meta-analysis
Astaxanthin may serve as a potential adjuvant treatment for PCOS by addressing oxidative stress and inflammation Astaxanthin Shows Potential to Manage Polycystic Ovary Syndrome Symptoms
This systematic review explores the therapeutic potential of astaxanthin for Polycystic ovary syndrome (PCOS) through antioxidant, anti-infl…
Astaxanthin may help manage symptoms of Polycystic Ovary Syndrome (PCOS) by reducing inflammation and improving insulin sensitivity in the b…
Frontiers Jul 16, 2026
Serum 25-hydroxyvitamin D shows significant inverse correlation with insulin resistance indices in women with PCOS
Oncology Meta-analysis
Serum 25-hydroxyvitamin D shows significant inverse correlation with insulin resistance indices in women with PCOS Vitamin D Levels Linked to Insulin Resistance in PCOS
This meta-analysis of 1856 women with Polycystic Ovary Syndrome found a significant inverse correlation between serum 25(OH)D and insulin re…
Lower vitamin D levels are linked to higher insulin resistance in women with Polycystic Ovary Syndrome, especially in specific groups.
Jul 4, 2026
GLP-1 receptor agonists combined with metformin most effectively reduce weight and BMI in PCOS
Diabetes & Endocrinology Meta-analysis
GLP-1 receptor agonists combined with metformin most effectively reduce weight and BMI in PCOS GLP-1 Combined With Metformin Shows Weight Loss For PCOS
This network meta-analysis evaluated GLP-1 receptor agonists, metformin, and myoinositol for managing polycystic ovary syndrome. The study f…
A combination of GLP-1 receptor agonists and metformin may be more effective for weight loss in women with polycystic ovary syndrome than ot…
Frontiers Jul 3, 2026
Gut microbiota-mitochondria axis offers a dual-targeted therapeutic framework for gynecological diseases
OB/GYN & Women's Health Sys. Review
Gut microbiota-mitochondria axis offers a dual-targeted therapeutic framework for gynecological diseases Gut Health and Mitochondria May Impact Gynecological Diseases
This systematic review explores the gut microbiota-mitochondria axis and its role in metabolism, immunity, and endocrine regulation in condi…
New research explores how the link between gut bacteria and cell energy could offer new ways to treat conditions like PCOS and endometriosis…
Frontiers Jul 2, 2026
Total testosterone and BMI predict clomiphene citrate resistance in 6.8% of women with PCOS
Diabetes & Endocrinology RCT
Total testosterone and BMI predict clomiphene citrate resistance in 6.8% of women with PCOS High Testosterone and BMI Predict Clomiphene Resistance in PCOS
This post-hoc analysis of a multicenter randomized controlled trial involving 471 infertile women with polycystic ovary syndrome (PCOS) iden…
New analysis shows that high testosterone levels and higher body mass index can help predict if clomiphene citrate will work for women with …
Frontiers Jun 30, 2026
Polycystic Ovary Syndrome associated with higher neonatal jaundice rates in Gestational Diabetes Mellitus
Oncology RCT
Polycystic Ovary Syndrome associated with higher neonatal jaundice rates in Gestational Diabetes Mellitus Women with PCOS face higher rates of infant jaundice during pregnancy
This secondary analysis of a randomized controlled trial involving 425 pregnant women with Gestational Diabetes Mellitus and BMI ≥25 kg/m² f…
A new look at pregnancy data shows that babies born to mothers with Polycystic Ovary Syndrome have higher rates of jaundice.
Jun 18, 2026
Non-obese women with PCOS show no significant differences in serum vitamin D levels
Diabetes & Endocrinology Meta-analysis
Non-obese women with PCOS show no significant differences in serum vitamin D levels Vitamin D Levels Show No Difference in Non-Obese PCOS Patients
This meta-analysis of cross-sectional data examined serum 25(OH)D and 1,25(OH)2D levels in non-obese women with polycystic ovary syndrome. N…
New data suggests that vitamin D levels may be linked to weight rather than the underlying causes of Polycystic Ovary Syndrome.
Frontiers Jun 16, 2026
58% of women with PCOS have vitamin D deficiency, meta-analysis finds
Nutrition & Obesity Medicine Meta-analysis
58% of women with PCOS have vitamin D deficiency, meta-analysis finds High Rates of Vitamin D Deficiency Found in Women with PCOS
This meta-analysis of 4,773 women with PCOS found a 58% prevalence of vitamin D deficiency. The finding highlights a common comorbidity but …
More than half of the women studied with Polycystic Ovary Syndrome (PCOS) were found to have a deficiency in vitamin D.
Frontiers Jun 15, 2026
Yoga may improve anthropometric, metabolic, endocrine, and psychological outcomes in women with PCOS
OB/GYN & Women's Health Meta-analysis
Yoga may improve anthropometric, metabolic, endocrine, and psychological outcomes in women with PCOS Yoga may help women with Polycystic Ovary Syndrome
This systematic review of nine randomized controlled trials found that yoga interventions were associated with improvements in anthropometri…
A review of trials suggests yoga can improve weight, hormones, and mood for women with Polycystic Ovary Syndrome, but more research is neede…
Frontiers Jun 3, 2026

Questions about Polycystic Ovary Syndrome

Does being obese make Autoimmune Thyroiditis more common in women with PCOS?

Yes, obesity is linked to a higher prevalence of autoimmune thyroiditis in women with PCOS, with one study showing 23.6% in obese vs. 18.6% in non-obese.

Full answer →
How does exposure to endocrine disrupting chemicals affect metabolic markers in Polycystic Ovary Syndrome?

Higher exposure to endocrine disrupting chemicals (EDCs) like BPA and phthalates is linked to worse metabolic markers in PCOS, including higher fasting insulin and insulin resistance.

Full answer →
What common genes link Polycystic Ovary Syndrome and type 2 diabetes according to recent studies?

Recent studies link PCOS and type 2 diabetes through shared genetic variants, notably the insulin gene VNTR and epigenetic changes in metabolism-related genes.

Full answer →
Are women with Polycystic Ovary Syndrome more likely to have autoimmune thyroiditis if they are obese?

Yes, a retrospective study found that obese women with PCOS have a higher prevalence of autoimmune thyroiditis (23.6%) compared to non-obese women with PCOS (18.6%).

Full answer →

All Polycystic Ovary Syndrome Articles