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Home › Conditions › Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

Part of Ovarian Cysts

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Polycystic Ovary Syndrome

64 trials tracked for Polycystic Ovary Syndrome: 27 in phase 3 or 4 and 13 with published results. The most-cited published study has 6045 citations.

64Trials tracked
27Phase 3 & 4
0Recruiting
13With published results
Phase distribution
Phase 4 10 Phase 3 17 Phase 2 11 Phase 1 4 Other / NA 22
  1. Phase 4 The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS Completed · 6,045 cited
  2. Phase 4 LIPT - Liraglutide in Polycystic Ovary Syndrome Completed · 165 cited
  3. Phase 3 Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS Completed · 154 cited
  4. Phase 4 The Effects of Vitamin D on Angiogenic Factors in Women With Polycystic Ovary Syndrome Completed · 114 cited
  5. Phase 4 Combined Letrozole and Clomid in Women With Infertility and PCOS Completed · 96 cited
  6. Phase 3 EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS) Completed · 92 cited
Show 44 more trials
  1. Phase 3 Liver and Fat Regulation in Overweight Adolescent Girls Completed · 85 cited
  2. Phase 4 Insulin Resistance, Polycystic Ovary Syndrome, and Bone Research Study Completed · 44 cited
  3. Phase 4 The Effect of Dipeptidyl Peptidase 4 Inhibition on Growth Hormone Secretion in Women With Polycystic Ovarian Syndrome Completed · 39 cited
  4. Phase 3 Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis Completed · 30 cited
  5. Phase 3 Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome Completed · 17 cited
  6. Phase 3 Comparing the Effects of Oral Contraceptive Pills Versus Metformin Completed · 2 cited
  7. Phase 3 Treating PCOS With Semaglutide vs Active Lifestyle Intervention Completed
  8. Phase 4 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed
  9. Phase 4 Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS Completed
  10. Phase 4 Continuous Versus Cyclical OCP Use in PCOS Completed
  11. Phase 4 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed
  12. Phase 3 Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS) Completed
  13. Phase 3 Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS) Completed
  14. Phase 3 Metabolic and Neuro-Endocrine Effect of Treating PCOS in Adolescents Completed
  15. Phase 3 The Effect of Vitamin D Supplementation Among Overweight Jordanian Women With Polycystic Ovary Syndrome (PCOS) Completed
  16. Phase 3 Pregnancy in Polycystic Ovary Syndrome II Completed
  17. Phase 3 Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy Completed
  18. Phase 3 Theca Cell Function in Women With Polycystic Ovary Syndrome (PCOS) Completed
  19. Phase 3 Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Completed
  20. Phase 3 Analysis of Two Therapeutic With Cetrotide® in Polycystic Ovarian (PCO) Women in Assisted Reproductive Technology (ART) Completed
  21. Phase 3 Treatment of Adolescent Polycystic Ovary Syndrome (PCOS) Completed
  22. Phase 2 Study of Pharmacodynamics of LIK066 in Overweight and Obese Women With Polycystic Ovary Syndrome Completed
  23. Phase 2 Study of the Safety and Efficacy of Elagolix in Women With Polycystic Ovary Syndrome Completed
  24. Phase 2 Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS) Completed
  25. Phase 2 The University of Michigan PCOS Intervention Using Nutritional Ketosis Completed
  26. Phase 2 Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women Completed
  27. Phase 2 Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction Completed
  28. Phase 2 Cavitation Ultrasound in Treatment of Patients With PCOS Completed
  29. Phase 2 Vitamin D for the Treatment of Women With Polycystic Ovary Syndrome (PCOS) Completed
  30. Phase 2 A Trial of Lipitor (Atorvastatin) for the Treatment of Polycystic Ovary Syndrome (PCOS) in Women With Elevated Low-density Lipoprotein (LDL) Cholesterol Completed
  31. Phase 2 The Efficacy and Safety Study of Tung's Acupuncture for Polycystic Ovarian Syndrome Completed
  32. Phase 2 Androgen Excess as a Cause for Adipogenic Dysfunction in PCOS Women Completed
  33. Phase 1 Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS Completed
  34. Phase 1 Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome Completed
  35. Phase 1 Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome Completed
  36. Phase 1 Determining How Quickly Progesterone Slows LH Pulse Frequency Completed
  37. N/A Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS Completed
  38. N/A Behavioral Economics for Activity Motivation in Adolescents (BEAM) Completed
  39. N/A Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS) Completed
  40. N/A Sex Steroids, Sleep, and Metabolic Dysfunction in Women Completed
  41. N/A Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH. Completed
  42. N/A Evaluation of Vitamin D in Women With PCOS and Sexual Dysfunction Completed
  43. N/A Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea Completed
  44. N/A Nimodipine to Prevent LH Surge During Ovulation Induction: Blinded Placebo-controlled RCT Completed

Showing the 50 most-cited and recently-updated of 64 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Yoga may improve anthropometric, metabolic, endocrine, and psychological outcomes in women with PCOS
OB/GYN & Women's Health Meta-analysis
Yoga may improve anthropometric, metabolic, endocrine, and psychological outcomes in women with PCOS Yoga may help women with Polycystic Ovary Syndrome
This systematic review of nine randomized controlled trials found that yoga interventions were associated with improvements in anthropometri…
A review of trials suggests yoga can improve weight, hormones, and mood for women with Polycystic Ovary Syndrome, but more research is neede…
Frontiers Jun 3, 2026
GLP-1 agonists show short-term metabolic benefit in PCOS but reproductive effects remain uncertain
Nutrition & Obesity Medicine Meta-analysis
GLP-1 agonists show short-term metabolic benefit in PCOS but reproductive effects remain uncertain Doctors suggest GLP-1 drugs help weight but need careful planning before pregnancy in PCOS
A meta-analysis of GLP-1 receptor agonists in PCOS found relatively robust support for short-term metabolic benefit, but reproductive outcom…
New analysis shows GLP-1 drugs help with weight loss for PCOS patients. However, doctors are unsure if these drugs improve fertility and nee…
Frontiers Jun 2, 2026
Metformin shows limited impact on gonadotropin levels in PCOS women
OB/GYN & Women's Health Meta-analysis
Metformin shows limited impact on gonadotropin levels in PCOS women Metformin changes one hormone ratio but leaves others unchanged in PCOS
A meta-analysis of 51 RCTs finds metformin does not alter FSH or LH but significantly increases the LH/FSH ratio in women with PCOS.
Metformin treatment significantly increased the LH to FSH ratio in women with PCOS, while leaving FSH and LH levels alone.
Jun 1, 2026
Lifestyle strategies improve metabolic and hormonal outcomes in PCOS, review finds
OB/GYN & Women's Health Sys. Review
Lifestyle strategies improve metabolic and hormonal outcomes in PCOS, review finds Lifestyle strategies may help manage polycystic ovary syndrome symptoms in women
This narrative review in reproductive-aged women with PCOS finds that dietary approaches, structured physical activity, and adjunct strategi…
A review suggests dietary changes, exercise, and psychological support can improve metabolic and hormonal outcomes for women with polycystic…
Frontiers May 29, 2026
Review of a case report on Type A insulin resistance syndrome in an adolescent
Diabetes & Endocrinology Sys. Review
Review of a case report on Type A insulin resistance syndrome in an adolescent Genetic test clarifies rare insulin resistance in teen with PCOS
This publication is a review and case report of a 12-year-old female with Type A insulin resistance syndrome and polycystic ovary syndrome. …
A 12-year-old girl with severe insulin issues and PCOS features had a new gene variant found, changing how her condition is understood and t…
Frontiers May 26, 2026
Systematic review links metabolic dysregulation to impaired oocyte quality and embryonic development potential
OB/GYN & Women's Health Sys. Review
Systematic review links metabolic dysregulation to impaired oocyte quality and embryonic development potential Metabolic chaos harms egg quality and early embryo growth
This systematic review examines the impact of metabolic reprogramming on oocytes in conditions including diabetes, obesity, polycystic ovary…
Metabolic problems like diabetes and obesity damage egg quality and stop embryos from developing well, which affects fertility for many.
Frontiers May 21, 2026
Systematic bibliometric review maps nutritional strategy research in polycystic ovary syndrome
OB/GYN & Women's Health Sys. Review
Systematic bibliometric review maps nutritional strategy research in polycystic ovary syndrome Research reveals top nutrition strategies for PCOS
This systematic bibliometric analysis reviewed 1248 publications on nutritional strategies for polycystic ovary syndrome. Top contributing c…
A new analysis maps the most studied nutrition strategies for PCOS, highlighting gut health and keto as emerging areas.
Frontiers May 20, 2026
Tai Chi and dietary adjustment for improving health lifestyle in women with PCOS
Diabetes & Endocrinology RCT
Tai Chi and dietary adjustment for improving health lifestyle in women with PCOS Tai Chi and diet may help manage PCOS symptoms
In this randomized controlled trial of 120 female college students with PCOS, combining dietary adjustment with 24-style simplified Tai Chi …
Adding simplified Tai Chi to dietary changes may improve lifestyle scores and hormone levels for young women with PCOS.
Frontiers Apr 30, 2026
Narrative review proposes redox-guided framework for vitamin D, myo-inositol, and melatonin in PCOS
OB/GYN & Women's Health Sys. Review
Narrative review proposes redox-guided framework for vitamin D, myo-inositol, and melatonin in PCOS Researchers propose new PCOS framework using vitamin D and melatonin
This narrative review synthesizes existing data on combined vitamin D, myo-inositol, and melatonin supplementation for polycystic ovary synd…
A new framework suggests combining vitamin D, myo-inositol, and melatonin for PCOS ovulation and insulin markers.
Frontiers Apr 28, 2026
Preprint trial of Tianjing Zelan formula shows improvements in menstrual and metabolic markers in PCOS models
Oncology
Preprint trial of Tianjing Zelan formula shows improvements in menstrual and metabolic markers in PCOS models Herbal Formula Helps Restore Menstrual Cycles in PCOS
This preprint describes a multicenter, single-arm clinical trial involving two PCOS models: patients and mice.
Many women struggle with irregular periods and trouble getting pregnant.
Apr 24, 2026
Autoimmune Thyroiditis Prevalence Higher in Obese Women With PCOS in Retrospective Cohort Analysis
OB/GYN & Women's Health Cohort
Autoimmune Thyroiditis Prevalence Higher in Obese Women With PCOS in Retrospective Cohort Analysis New PCOS Data Reveals Hidden Thyroid Risks
This retrospective cohort study evaluated 1,249 women with PCOS aged 18–44 years.
Women with PCOS should check their thyroid health regularly.
Frontiers Apr 22, 2026
Meta-analysis review synthesizes EDC exposure levels and metabolic markers in patients with PCOS versus controls
Oncology Meta-analysis
Meta-analysis review synthesizes EDC exposure levels and metabolic markers in patients with PCOS versus controls Chemicals in Your Body May Trigger PCOS
This meta-analysis review examines endocrine disrupting chemical (EDC) exposure in patients with polycystic ovary syndrome (PCOS) compared t…
Common environmental chemicals found in our daily lives might be silently increasing the risk of polycystic ovary syndrome.
Apr 16, 2026

Questions about Polycystic Ovary Syndrome

Does being obese make Autoimmune Thyroiditis more common in women with PCOS?

Yes, obesity is linked to a higher prevalence of autoimmune thyroiditis in women with PCOS, with one study showing 23.6% in obese vs. 18.6% in non-obese.

Full answer →
How does exposure to endocrine disrupting chemicals affect metabolic markers in Polycystic Ovary Syndrome?

Higher exposure to endocrine disrupting chemicals (EDCs) like BPA and phthalates is linked to worse metabolic markers in PCOS, including higher fasting insulin and insulin resistance.

Full answer →
What common genes link Polycystic Ovary Syndrome and type 2 diabetes according to recent studies?

Recent studies link PCOS and type 2 diabetes through shared genetic variants, notably the insulin gene VNTR and epigenetic changes in metabolism-related genes.

Full answer →
Are women with Polycystic Ovary Syndrome more likely to have autoimmune thyroiditis if they are obese?

Yes, a retrospective study found that obese women with PCOS have a higher prevalence of autoimmune thyroiditis (23.6%) compared to non-obese women with PCOS (18.6%).

Full answer →

All Polycystic Ovary Syndrome Articles