Phase 3
Completed N=588
A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092)
Postoperative Dental Pain
Source: ClinicalTrials.gov NCT00694369 ↗
Enrolled (actual)
588
Serious AEs
0.0%
Results posted
Jan 2010
Primary outcomePrimary: Total Pain Relief Score Over the First 6 Hours Post the Initial Day 1 Dose of the Study Medication (TOPAR6) — 5.08; 16.10; 15.73; 15.67 Units on a Scale — p=<0.001
Summary
The purpose of this study is to compare the pain relieving effect of different doses of MK0663 with placebo and other pain relievers/analgesics in patients with postoperative dental pain. Pain intensity and relief will be measured by the total pain relief score (TOPAR) and patient evaluation.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Pain Relief Score Over the First 6 Hours Post the Initial Day 1 Dose of the Study Medication (TOPAR6) |
5.08; 16.10; 15.73; 15.67; 11.83 | <0.001 sig |
| SECONDARY Patient's Global Assessment of Study Medication at 24 Hours Post the Initial Day 1 Dose of the Study Medication |
19; 12; 7; 6; 1; 12 | <0.001 sig |
Eligibility Criteria
Inclusion Criteria
- Patients must be scheduled to have 2 or more third molars removed, at least 1 of which is partially embedded in bone and is impacted in the lower jaw
- Patients must be experiencing moderate to severe pain following the dental procedure
Exclusion Criteria
- Previous molar extraction within the past 45 days
- Personal or family history of an inherited bleeding disorder
- Uncontrolled high blood pressure
Data sourced from ClinicalTrials.gov (NCT00694369). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.