Phase 4
Completed N=12
The Effect of Protein on Calcium Absorption and Gastric Acid Production
Source: ClinicalTrials.gov NCT00719160 ↗Enrolled (actual)
12
Serious AEs
0.0%
Results posted
Jan 2013
Primary outcomePrimary: Percent Change in Intestinal Calcium Absorption — 34.2; 31.5 percentage of calcium absorption
Summary
We have established that dietary protein is an important regulator of intestinal calcium absorption in humans. However, we do not understand the mechanism by which dietary protein is affecting calcium absorption. Therefore, the purpose of this research is to evaluate whether dietary protein-induced changes in gastric acid secretion explain the observed changes in intestinal calcium absorption.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent Change in Intestinal Calcium Absorption |
34.2; 31.5 | — |
| SECONDARY Gastric pH |
5.38; 2.70 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy men and women age 18-45 years
- Caucasian or Asian descent due to increased risk of Osteoporosis
Exclusion Criteria
- gastrointestinal diseases
- osteoporosis
- diabetes
- hypertension
- liver disease
- thyroid disorders
- kidney disease
- kidney stones
- cancer
- heart disease
- eating disorders
- obesity
- hypogonadism
- amenorrhea
- oligomenorrhea
- abnormal serum FSH or estradiol levels
- birth control medication or other hormone-altering medications
- pregnancy
- Lifestyle factors such as:
- smoking
- excessive exercise (although moderate exercise is allowed)
- prescription medications known to influence vitamin D or calcium metabolism or gastric acid
- excessive body weight change during the past 6 months
- food allergies
- unusual eating habits or medically prescribed diets
Data sourced from ClinicalTrials.gov (NCT00719160). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.