N/A
N=12
The Differential Effects of 3 Different Immunosuppressive
Immunosuppression · Kidney Transplantation
Bottom Line
View on ClinicalTrials.gov: NCT00729248 ↗Enrolled (actual)
12
Serious AEs
0.0%
Results posted
Aug 2013
Primary outcome: Primary: CD4+CD25 High FOXP3+ Cell Levels in Mixed Lymphocyte Reactions (MLRs) of Renal Pre-transplant Recipients/Donors — 90; 85; 25; 50 Percentage of Control Cells
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Northwestern University
- Primary completion
- Jul 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY CD4+CD25 High FOXP3+ Cell Levels in Mixed Lymphocyte Reactions (MLRs) of Renal Pre-transplant Recipients/Donors |
90; 85; 25; 50; 10; 45 | — |
Summary
The study is a laboratory investigation comparing the regulatory effects of different immunosuppressive therapies in an in vitro human MLR assay of selecting specific immunosuppressive therapy to promote a regulatory profile and determining possibly newer accepted dosing and drug concentrations for agents most associated with this regulatory profile.
Eligibility Criteria
Inclusion Criteria
- Adults 18 years of Age or Older
- Undergoing living donor renal transplant
Exclusion Criteria
- No active infection or history of malignancy
- No HIV infection
- No Hepatitis C (HCV) infection
- No prior transplant (kidney or other organ)
- No chromic use of immunosuppressive therapy or history of autoimmune disease
Data sourced from ClinicalTrials.gov (NCT00729248). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.