Chronic Kidney Disease

All Chronic Kidney Disease Articles

• CKD-MBD care should shift from biochemical targets to phenotype-informed, outcome-oriented management
• Kidney and brain share common pathways linking renal dysfunction to neurological impairment
• H. pylori eradication linked to lower proteinuria and reduced CKD risk in meta-analysis
• nsMRAs reduce UACR and systolic BP in patients with diabetic kidney disease
• Intermittent Hemodialysis Falls Short of Continuous Therapy in Critically Ill AKI Trial
• Monocyte and macrophage sensing of calciprotein particles triggers inflammasome activation and interleukin-1β release
• Metabolic profiles and specific metabolites serve as potential biomarkers for diabetic kidney disease progression
• Unhealthy food environments and ultra-processed foods contribute to obesity and related cardiometabolic diseases
• suPAR predicts incident CKD and ESKD in adults with preserved kidney function
• Resistance training improves eGFR in non-dialysis diabetic kidney disease while mind-body exercise reduces UAE
• RAAS inhibitors modulate inflammatory responses and oxidative stress across multiple chronic conditions
• Glutamine metabolism serves as a critical energy substrate and potential therapeutic target in AKI and CKD
• Multiple biomarkers show potential associations with kidney function decline in patients with type 2 diabetes
• HIF-prolyl hydroxylase inhibitors cause modest VEGF increases and reproducible peripheral edema in chronic kidney disease
• Hemodiafiltration in Neonates: Narrative Review Maps Applications but Reports No Clinical Outcomes
• Mineralocorticoid receptor antagonists exert cardioprotective effects by restoring coronary microvascular function
• Higher H3.1 nucleosome levels associate with 48% increased 28-day mortality in septic shock
• Iron chelation reduces serum ferritin and iron while increasing hemoglobin in chronic kidney disease
• SGLT2 inhibitors attenuate urinary EGF decline and correlate with improved outcomes in chronic kidney disease
• Hypoglycemia prediction models show a pooled AUC of 0.846 for patients with diabetic kidney disease
• Hyperuricemia acts as an independent risk factor for progression of chronic kidney disease in children
• SGLT2 inhibitors improve glycemic control and blood pressure in patients with diabetic chronic kidney disease
• Selective aldosterone synthase inhibitors reduce systolic blood pressure by 7.9 mmHg in patients with CKD
• Sickle cell trait is associated with increased risk of kidney disease, pulmonary embolism, and anemia
• Pulmonary hypertension prevalence 37% in maintenance hemodialysis patients, meta-analysis finds
• URS and RIRS do not worsen eGFR in CKD, with possible improvement in ureteral stones
• Virtual reality interventions improve gait speed and reduce pain and depressive symptoms in hemodialysis patients
• Androgen deprivation therapy is associated with an OR 1.34 for acute kidney injury
• SGLT2 inhibitors provide the greatest risk reduction for kidney outcomes in type 2 diabetes
• SIRT1 Activation Targets Fibrosis, Inflammation, and Anemia in Chronic Kidney Disease
• Higher CGM-derived time in range is associated with lower odds of diabetic kidney disease
• Fisetin shows potential as a nutritional senotherapeutic but lacks clinical evidence for chronic kidney disease
• AKI Affects 30.7% of Pediatric Liver Transplant Recipients in Pooled Analysis
• CD4+ T cell subset imbalance drives renal inflammation and fibrosis in diabetic kidney disease
• Healthyer dietary patterns and physical activity may improve renal and metabolic outcomes in type 2 diabetes
• Controlled low central venous pressure with nitroglycerin reduces 7-day postoperative AKI by 14.9% absolute risk
• Astragaloside IV significantly reduces renal fibrosis markers and serum creatinine in preclinical animal models
• Gut-kidney axis drives sepsis-associated AKI, review argues for microecological and neuromodulatory therapies
• Intradialytic exercise improves cardiovascular function and arterial stiffness in patients on maintenance haemodialysis
• Four mailer types aim to increase health care proxy documentation in patients with chronic conditions
• High abdominal aortic calcification index predicts poorer cardiovascular event-free survival in patients with chronic kidney disease
• Pegylated erythropoietin provides improved Hb stability and reduced dosing frequency in CKD-related anemia
• Elevated Visceral Adiposity Index is associated with increased risk of diabetic kidney disease
• CABG reduces all-cause death and repeat revascularisation risk in patients with diabetes and CKD
• AVF ligation reduces left ventricular mass index by 10.92 g/m in end-stage kidney disease
• Vitamin D deficiency is associated with 33% higher odds of progression in chronic kidney disease
• Pre-stenting increases FANS-UAS placement success from 80.0% to 94.8% in RIRS for kidney stones
• Targeted strategies like senolytics and PFKFB3 blockers show preclinical efficacy in chronic kidney disease
• Exercise training increases circulating s-Klotho levels in adults with CKD and sarcopenia
• Dapagliflozin Reduces Acute Kidney Injury Incidence in Patients Undergoing Elective Cardiac Surgery
• Alert-based CDS increases UACR testing from 11.5% to 36.0% in patients with type 2 diabetes
• Elevated glucose, chloride, and anion gap levels are associated with increased risk of acute kidney injury
• Periodontal conditions and plaque index correlate with lower oral health-related quality of life in ESRD patients
• Salivary urea, creatinine, calcium, and pH are significantly higher in patients with chronic kidney disease
• MDS patients have 6.2 times higher cardiovascular disease prevalence than the general population
• Dysregulated tryptophan metabolism drives neurocognitive complications in approximately 40% of patients with chronic kidney disease
• Protein-energy wasting prevalence reaches 47.0% among patients with chronic kidney disease in Africa
• Oral microbiome dysbiosis is observed in children and adolescents with chronic kidney disease
• Intranasal desmopressin reduces bleeding risk in CKD patients during non-surgical procedures
• Star fruit-infused liquor consumption can cause secondary oxalate nephropathy and acute kidney injury
• cGAS-STING pathway activation drives inflammation, fibrosis, and podocyte injury in various kidney diseases
• Natural products like polysaccharides and TCM formulas may modulate gut microbiota to protect renal function
• Targeting cannabinoid receptors may modulate CKD and AKI progression in animal models
• Machine learning supports individualized tacrolimus dosing but lacks long-term dynamic regulation
• Elevated syndecan-1 levels correlate with severity and poor outcomes in patients with sepsis
• Machine learning models achieve a pooled AUC of 0.834 for predicting acute kidney injury occurrence
• Educational interventions significantly improve knowledge and quality of life for patients on peritoneal dialysis
• High-risk APOL1 genotypes more than double odds of lupus nephritis ESRD
• Reduced-dose daratumumab and bortezomib may achieve partial renal remission in CyBorD-refractory PGNMID
• RIT1 p.Thr83Pro variant is associated with severe neonatal outcomes in Noonan syndrome cases
• Dietary fiber reduces indoxyl sulfate by 0.13 mg/dL in humans with CKD
• Sacubitril/valsartan associated with improved renal outcomes in patients with heart failure
• MASLD is associated with higher CKD prevalence and accelerated renal impairment progression
• CKD-MBD medication titration is associated with serum calcium, phosphorus, and parathyroid hormone levels
• Ivonescimab-containing chemoimmunotherapy can trigger rare ADAMTS13 inhibitor-positive immune thrombotic thrombocytopenic purpura
• Chronic kidney disease is associated with increased plaque, calculus, and gingival inflammation
• Combined nutrition and exercise improves physical performance in patients on hemodialysis
• Finerenone reduces UACR by 25% in adults with type 1 diabetes and CKD
• Mitochondrial metabolic reprogramming and epigenetic modifications drive bidirectional regulation in renal tubular epithelial cells
• Insulin resistance and hyperinsulinemia drive bidirectional links between biological aging and age-related chronic diseases
• Natural products offer multi-target renoprotective effects for metabolic, inflammatory, and oxidative stress pathways
• Chronic kidney disease prevalence of 13.7% identified across 19 African countries
• Frailty associated with higher odds of cognitive impairment in patients with chronic kidney disease
• GLP-1 receptor agonists and tirzepatide provide cardiovascular benefits across multiple clinical scenarios
• Herbal Medicinal Bath shows stable efficacy for chronic kidney disease-associated pruritus in network meta-analysis
• PPI Guided Fluid Resuscitation Reduces Incidence of Acute Skin Failure in Critically Ill Patients
• Inflammation and immune dysregulation drive chronic kidney disease progression and associated tissue remodeling
• Staged PCI reduces severe kidney injury risk after TAVR in aortic stenosis and CAD
• Finerenone Efficacy and Safety in Patients with Chronic Kidney Disease and Glomerular Disease
• Vitamin D supplementation shows low certainty reductions in urinary markers for diabetic kidney disease
• Unified cardiometabolic disease framework links T2DM, ASCVD, HFpEF, MASLD, hypertension, and CKD via shared pathophysiology
• Age, male sex, low BMI, and comorbidities like diabetes are significant risk factors for sepsis incidence
• m6A modification regulates renal tubular epithelial cell fate and inflammatory responses in acute kidney injury
• Mediterranean and DASH diets consistently support mitigation of cardiometabolic risk in metabolic syndrome patients
• Immune checkpoint inhibitors are associated with acute kidney injury and multi-organ immune-related adverse events
• PCSK9 monoclonal antibodies show promise for renal benefit in diabetic kidney disease
• Health literacy is moderately associated with improved self-care behaviors in patients with multiple chronic diseases
• Renal vascular variations do not compromise long-term outcomes in patients with complex anatomy
• Lipid metabolism disorders drive podocyte injury and extracellular matrix deposition in diabetic kidney disease
• Serum cystatin C shows consistent increase in cats with CKD while urinary cystatin B elevates in dogs
• KidneyTIME digital intervention improves knowledge and listing behaviors but not donor inquiries in kidney transplant candidates
• Inclisiran reduces LDL cholesterol by up to 54.7% in patients with atherosclerotic cardiovascular disease
• Dapagliflozin reduces proteinuria and blood pressure but does not improve eGFR in CAD patients
• Higher Triglyceride-Glucose index is associated with increased risk of albuminuria in chronic kidney disease
• Higher Systolic Blood Pressure Time in Target (SBP TTR) associated with 10% lower risk of poor kidney outcomes
• Children with posterior urethral valves and adverse prognostic features have 1.44 times higher CKD risk
• Canagliflozin mitigates increased cardiovascular risk from low-normal sodium intake in type 2 diabetes and CKD
• Pooled prevalence of diabetic kidney disease among Brazilian adults is 27.06% across 46 studies
• Semaglutide significantly reduces BMI and improves hypertension control in patients with obesity and CKD
• Finerenone reduces mortality and heart failure risk (HR 0.644) in post-AMI patients
• Post-translational modifications represent a critical target for precise molecular intervention in diabetic kidney disease
• Digital health technologies offer varying levels of clinical readiness for managing sarcopenia in hemodialysis patients
• Continuous renal replacement therapy may support metabolic and circulatory stability in preterm infants with AKI
• Programmed cell death pathways form a spatiotemporally regulated network driving tubular damage in renal IRI
• Machine learning models show high diagnostic accuracy for predicting pediatric cardiac surgery associated acute kidney injury
• Peripheral nerve blocks reduce 24-hour morphine use by 16.20 mg in kidney transplant recipients
• Active stone-directed intervention reduces odds of composite recurrence and surgery for asymptomatic kidney stones
• Roxadustat increases odds of vascular access thrombosis and all-cause mortality in patients with chronic kidney disease
• Ambulatory hypertension in pediatric chronic kidney disease patients increases risk of left ventricular hypertrophy
• Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
• Risk-adapted HLA delisting and imlifidase enable deceased-donor kidney transplantation for highly sensitized candidates
• Semaglutide reduces risk of kidney decline or death in type 2 diabetes and CKD
• Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
• Semaglutide use may be associated with kidney damage in 20 cases across 18 studies
• Jinlida Granule reduces serum creatinine and HbA1c in diabetic kidney disease patients across a meta-analysis
• Steroid avoidance may reduce death and diabetes after kidney transplant but raises rejection risk
• ILC dysregulation and gut microbiota dysbiosis may drive kidney disease via the microbiota-gut-kidney axis
• Kidney transplantation reduces left-ventricular mass index by 22 g/m² in end-stage kidney disease
• Pulsed-field ablation shows no significant AKI difference versus radiofrequency ablation in AF
• Fluoroless ultrasound-guided techniques lower complications in percutaneous nephrolithotomy with equivalent stone-free rates
• ECIRS triples stone-free odds versus PCNL in large kidney stones, meta-analysis finds
• Chronic kidney disease linked to shorter leukocyte telomere length in meta-analysis
• Education and behavior interventions reduce burden for CKD caregivers in a systematic review
• Acute kidney function decline timing predicts mortality and heart failure outcomes in hospitalized patients
• Gut dysbiosis contributes to CKD complications via interconnected pathways, though mechanistic validation remains incomplete
• Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications
• Cerivastatin best for total cholesterol, simvastatin for LDL-C in DKD with hyperlipidemia
• Nutritional vitamin D reduces CRP and improves albumin in maintenance hemodialysis patients
• Pyrethroid insecticide exposure linked to acute kidney injury in a 55-year-old male
• Case report confirms X-linked Alport syndrome diagnosis in a young girl with family history
• Clinical and laboratory abnormalities linked to higher mortality in malaria patients with acute kidney injury
• Complement activation in acute kidney injury a convergent mechanism
• Systematic review and meta-analysis links prenatal NSAIDs to higher kidney disease risk in children
• Systematic review and meta-analysis of prediction models for diabetic kidney disease progression to ESRD
• Systematic review and meta-analysis on FGF23 levels in diabetic kidney disease
• Mini review of Explainable AI for kidney stone segmentation in resource-constrained settings
• Narrative review of salvianolic acids for kidney disease pharmacokinetics and anti-fibrotic activity
• Narrative review examines ureteroscopy with negative-pressure suction sheath for kidney and ureteral stones
• Meta-analysis finds lower bleeding risk with apixaban and rivaroxaban vs VKAs in dialysis patients with AF
• Narrative review explores gut-kidney axis in chronic kidney disease progression
• Meta-analysis finds SGLT2 inhibitors reduce cardiac arrest risk in CKD patients
• Combining finerenone with SGLT2 inhibitors lowers mortality and cardiovascular events in diabetic chronic kidney disease patients
• Meta-analysis links acute kidney injury to increased stroke, delirium, and dementia risk
• Narrative review of lung, breast, liver, and kidney cancer evidence
• Case report suggests hemorrhagic fever with renal syndrome may trigger secondary hyperparathyroidism
• Digital decision support tools showed parallel improvements with no between-group differences in kidney outcomes among adults with chronic kidney disease in Chinese primary care centers
• HIF-PHIs alter lipid profiles in CKD patients but show no cardiovascular mortality difference
• Pentoxifylline Improves Kidney Function and Reduces Inflammation in CKD
• Complication risks in elderly patients undergoing percutaneous nephrolithotomy compared to younger populations
• CABG versus PCI in high-risk coronary revascularisation patients shows mixed outcomes over 5 years
• Arterioarterial grafts show high patency in hemodialysis patients
• Systematic review links gestational diabetes to higher maternal CKD risk in large cohort analysis
• MUSKARDIA shows protective trend in stable CAD with reduced eGFR
• Amiloride and hydrochlorothiazide affect metabolites and ammonium excretion in CKD patients
• Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence
• Scoping review finds SGLT2 inhibitors show kidney protection in IgA nephropathy
• RIRS with TFLLT shows similar stone-free rates to PNL for 20-30 mm kidney stones in adults
• Hypophosphatemia during KRT linked to fewer ventilator-free days in critically ill patients
• Kidney-directed SBRT shows modest renal function decline in inoperable patients
• Omega-3 fatty acids fail to reduce inflammation in hemodialysis patients
• Systematic review and meta-analysis of health coaching interventions in chronic kidney disease patients
• Meta-analysis finds GLP-1RA plus SGLT2i reduces UACR in type 2 diabetes with kidney disease
• Systematic review and meta-analysis of MRAs in dialysis patients shows reduced nonfatal CVD events but elevated hyperkalemia and gynecomastia risks
• Permanent night shift work associated with increased chronic kidney disease risk in UK Biobank participants
• Pre-treatment body composition and acute kidney disease risk in head and neck cancer patients treated with cisplatin
• Systematic Review Links Lysosomal Pathways to Autoimmune Kidney Disease Progression
• Machine learning model identifies RLS in ESRD patients with AUC 0.791
• Mini Review Covers Complement Pathways in Kidney Diseases and Injuries
• Narrative review discusses renal risks in inflammatory bowel disease patients
• Higher sdLDL-C Linked to Lower Kidney Stone Risk in Two Cohorts
• Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes
• White blood cell indicators predict acute kidney injury in critically ill advanced colorectal cancer patients
• Higher TyG index linked to increased renal function progression risk in patients with CKD stages 3–4
• Observational study links cutaneous microvascular function to chronic kidney disease severity
• Individual-participant data meta-analysis shows blood-pressure lowering reduces cardiovascular risk in CKD and non-CKD populations
• Machine learning model improves early detection of occult diabetic kidney disease in hospitalized patients
• Oral beraprost extends median survival in dogs with IRIS stage 2 chronic kidney disease compared to historical controls
• Circulating SVEP1 Protein Associated With Major Adverse Cardiovascular Events in Hemodialysis Patients
• Cross-sectional study links declining nephron number to CKD stage in diabetic nephropathy
• Meta-analysis of dapagliflozin for renal outcomes in type 2 diabetes and CKD
• High-altitude ICU study finds 21% AKI incidence in neurocritical patients
• Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions
• Narrative review supports SGLT-2i use in cardiovascular-kidney-metabolic syndrome
• Systematic review and meta-analysis shows dapagliflozin increases hemoglobin in chronic kidney disease patients
• Systematic review and meta-analysis shows exercise improves depression and quality of life in hemodialysis patients
• Observational review of layered data models improves DKD risk detection in type 2 diabetes cohorts
• Systematic review of anti-IL-5 biologics in hypereosinophilic syndrome kidney disease reports low certainty evidence
• Inflammatory indices associated with increased chronic kidney disease risk in coronary artery disease cohort
• Systematic review examines oral microbiota associations with chronic kidney disease and early childhood caries
• Flexible suction sheath outperforms conventional sheath in renal stone surgery