N/A Completed N=92 Diagnostic

Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep

Source: ClinicalTrials.gov NCT00732199 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2017

Primary outcomePrimary: Apneic Threshold (AT) and Carbon-dioxide (CO2) Reserve — 39.8; 36.7; -4.1; -2.6 mm Hg — p=<0.05

Summary

The purpose for this research protocol was to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly. This proposal focused on key factors that contribute to the control of ventilation in elderly adults during sleep. The investigators studied the age-specific changes in ventilatory control in older and young adults during NREM sleep.

Outcome Measures

Outcome	Result	p-value
PRIMARY Apneic Threshold (AT) and Carbon-dioxide (CO2) Reserve	39.8; 36.7; -4.1; -2.6	<0.05 sig
PRIMARY Long-term Facilitation (LTF) of Ventilation, Minute Ventilation Was Measured in Older Adults Only	94.4	<0.05 sig
SECONDARY Hypoxic Ventilatory Response	0.21; 0.53	<0.05 sig
SECONDARY Brief Hyperoxia Response	89.7; 79.6	<0.05 sig

Eligibility Criteria

Inclusion Criteria

Healthy older and young adults

Exclusion Criteria

Pregnancy,
history of active coronary artery disease-including stable and unstable angina,
recent myocardial infarction,
history of congestive heart failure,
stroke,
excessive daytime sleepiness with Epworth Sleepiness Scale of >15
patient with OSA- (Obstructive sleep apnea) on therapy
depression,
schizophrenia,
untreated hypothyroidism,
diabetes on insulin,
seizure disorder,
intrinsic renal and liver disorders,
failure to give informed consent,
patients with evidence of pulmonary diseases based on history and abnormal pulmonary function testing, including obstructive (ratio of predicted forced expiratory volume to forced vital capacity, 34kg/m2
subjects with sleep apnea are already using continuous positive airway pressure for more than 7 days as therapy

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Data sourced from ClinicalTrials.gov (NCT00732199). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.