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Sleep apnea

Part of Sleep Disorders, Intrinsic

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for sleep apnea

48 trials tracked for sleep apnea: 1 in phase 3 or 4.

48Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 1 Phase 2 7 Phase 1 4 Other / NA 36
  1. Phase 3 Telemedicine Interventions for Obstructive Sleep Apnea (OSA) Completed
  2. Phase 2 Positional Therapy After Stroke Completed
  3. Phase 2 Chronic Evaluation of Respicardia Therapy Completed
  4. Phase 2 A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks Completed
  5. Phase 2 A Novel Pharmacological Therapy for Obstructive Sleep Apnea Completed
  6. Phase 2 A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults Completed
Show 42 more trials
  1. Phase 2 Dimethyl Fumarate for Obstructive Sleep Apnea Completed
  2. Phase 2 Effects of Treating Obstructive Sleep Apnea in Epilepsy Completed
  3. Phase 1 Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease? Completed
  4. Phase 1 Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036) Completed
  5. Phase 1 Pharmacodynamics and Efficacy of MK-7288 in Adults With Sleep Apnea (MK-7288-010) Completed
  6. Phase 1 Oxytocin on HR in Sleep Apnea Patient Completed
  7. N/A TatchSleep as a Tool to Aid in Sleep Apnea Analysis Completed
  8. N/A A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed
  9. N/A High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients Completed
  10. N/A Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy Completed
  11. N/A Mapping for Acute Transvenous Phrenic Nerve Stimulation Study Completed
  12. N/A Advancing Understanding of Transportation Options Completed
  13. N/A Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography Completed
  14. N/A Non-Inferiority Study of the FRESCA Mask Versus Existing CPAP Mask for Treatment of Obstructive Sleep Apnea Completed
  15. N/A Atrial Fibrillation Recurrence in Sleep Apnea Completed
  16. N/A Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep Completed
  17. N/A Treating Sleep Apnea in Women Veterans Completed
  18. N/A Diagnosis and Treatment of Sleep Apnea in the Acute Exacerbation of Heart Failure Completed
  19. N/A Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome Completed
  20. N/A Positive Airway Pressure for the Treatment of Asthma Completed
  21. N/A The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea Completed
  22. N/A A Validation Study of the NightOwl PAT-based Home Sleep Apnea Test Completed
  23. N/A Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea Completed
  24. N/A Non-Inferiority Study of the FRESCA Airbox Positive Airway Pressure System Completed
  25. N/A Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed
  26. N/A Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment Completed
  27. N/A Clinical Validation of New Commercial Sleep Monitoring Devices Completed
  28. N/A Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation Completed
  29. N/A Radiofrequency Ablation for Multi-level Obstructive Sleep Apnea: A Single-arm, Multicenter Study Completed
  30. N/A Tri Staple Technology Stapler Used in Gastric Bypass Completed
  31. N/A The Effects of Treating Obese and Lean Patients With Sleep Apnea Completed
  32. N/A Sleep Apnoea Breathing Record Exploratory Study (SABRES) Completed
  33. N/A Influence of Sleep Apnea on Risk of Atrial Fibrillation Completed
  34. N/A Estimating Apnea Phenotypes From Polysomnography: Oxygen Completed
  35. N/A Alice PDx User/Validation Extended Trial Completed
  36. N/A Modified AutoSet Device vs Existing AutoSet Device, the Assessment of Efficacy and Subjective Comfort of the Treatment. Completed
  37. N/A Long QT Syndrome and Sleep Apnea Completed
  38. N/A The Treatment of Insomnia Comorbid With Sleep Disordered Breathing Using Armodafinil and/or Cognitive Behavioral Therapy for Insomnia Completed
  39. N/A Addressing Insufficient PAP Use in Older Veterans Completed
  40. N/A Study Will Test the Theory That Training With the Facial-Flex Exercise Device Will Improve Snoring in Patients Completed
  41. N/A Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk Completed
  42. N/A Apnea Hypopnea Index Severity Versus Head Position During Sleep Completed

Showing the 48 most-cited and recently-updated of 48 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep apnea: what the trials found

Physical activity showed mixed results for sleep apnea outcomes. In one trial, changes in Epworth Sleepiness Scale score ranged from -2.62 to 0.43, and quality of life changes ranged from -0.33 to 1.24, with no significant differences reported 3.

A PAP adherence program significantly improved PAP adherence (2.16 vs 0.87, p=.0001) and daytime sleepiness (6.11 vs 7.59, p<0.001), but sleep quality was not significantly different (7.72 vs 8.01, p=0.378) 14.

The Apne-Scan DC1 device is a recent diagnostic tool for sleep apnea 2.

Supplemental oxygen is being investigated as a treatment for sleep apnea 1.

Atomoxetine is under investigation for sleep apnea 4.

Recent results — preliminary, needs further review

  • Supplemental oxygen is being explored as a potential treatment for sleep apnea 1.
  • The Apne-Scan DC1 device is a new diagnostic tool for sleep apnea 2.
  • Atomoxetine is under investigation for sleep apnea 4.
  • A PAP adherence program significantly improved PAP adherence and daytime sleepiness 14.
  • TatchSleep showed 89% agreement in AHI severity classification compared to polysomnography 15.

For the clinician treating this condition

  • PAP adherence programs can improve adherence and daytime sleepiness in sleep apnea patients 14.
  • Physical activity has mixed evidence for improving sleepiness and quality of life in sleep apnea 3.
  • New diagnostic tools like Apne-Scan DC1 and TatchSleep are emerging for sleep apnea assessment 215.

AI synthesis of 6 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Sleep Disorders, Intrinsic

Related studies from across the Sleep Disorders, Intrinsic family.

AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection
Radiology & Imaging Meta-analysis
AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection AI tools show promise for screening obstructive sleep apnea
This meta-analysis of 60 studies evaluated the diagnostic accuracy of AI-based screening tools for obstructive sleep apnea. The analysis fou…
New data shows AI tools can accurately identify obstructive sleep apnea, helping doctors find patients who need treatment more effectively.
Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk
Emergency Medicine Sys. Review
Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk Sleep disorders significantly impact recovery for stroke patients
This narrative review examines the prevalence and impact of sleep disorders, including obstructive sleep apnea (OSA), in stroke patients. Th…
Up to 84% of stroke patients suffer from sleep disorders, which can hinder recovery and increase the risk of future strokes.
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders
Psychiatry Meta-analysis
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders Trazodone may improve sleep quality for people with depression
This exploratory meta-analysis of 5 RCTs and 3 single-arm studies indicates that trazodone improves total sleep time and sleep efficiency wh…
Trazodone may help people with depression get more sleep and fall asleep faster, though it can cause side effects like dizziness and sleepin…
OSA Tied to Poorer Glucose Control in Type 2 Diabetes
Diabetes & Endocrinology Meta-analysis
OSA Tied to Poorer Glucose Control in Type 2 Diabetes Sleep Apnea Linked to Poorer Blood Sugar Control in Diabetes
Obstructive sleep apnoea is consistently linked to worse glucose control and insulin resistance in people with type 2 diabetes or prediabete…
People with Type 2 Diabetes and sleep apnea may face harder blood sugar management and higher insulin resistance.
Sleep disorders affect 50% of patients with amyotrophic lateral sclerosis in meta-analysis
Neurology Meta-analysis
Sleep disorders affect 50% of patients with amyotrophic lateral sclerosis in meta-analysis Half of people with ALS experience sleep disorders
This meta-analysis of 2,762 patients with amyotrophic lateral sclerosis (ALS) found a pooled prevalence of sleep disorders of 50% (95% CI, 4…
Over half of people living with ALS struggle with sleep issues, with older patients showing a higher risk for these common sleep problems.
Comparative Efficacy of Implantable Upper Airway Stimulation and Surgical Interventions for OSA
Physical Medicine & Rehab Sys. Review
Comparative Efficacy of Implantable Upper Airway Stimulation and Surgical Interventions for OSA Implantable Stimulation Shows Better Results for Obstructive Sleep Apnea
A network meta-analysis indicates that implantable upper airway stimulation offers superior AHI reduction and higher cure rates compared to …
A new analysis shows that implantable airway stimulation provides better results and shorter hospital stays than surgery for moderate to sev…
Zebrafish platform proposed to bridge natural product sleep research gaps
Nutrition & Obesity Medicine Sys. Review
Zebrafish platform proposed to bridge natural product sleep research gaps Plant Products May Help Manage Sleep Disorders in Future Research
This narrative review proposes zebrafish as a translational filter to evaluate plant-derived natural products for sleep modulation. The auth…
Researchers are using zebrafish to test how plant-derived products might help treat sleep disorders and develop functional foods.
Orexin receptor antagonists improve sleep continuity by blocking orexin-mediated arousal signaling pathways
Oncology Sys. Review
Orexin receptor antagonists improve sleep continuity by blocking orexin-mediated arousal signaling pathways New drugs target the brain's wake signals to treat insomnia
This narrative review explores the mechanism and physiological effects of orexin receptor antagonists in treating insomnia. The authors conc…
A new class of medications works by blocking the chemicals that keep your body awake, offering a different way to manage sleep disorders.
COPD and OSA overlap syndrome is associated with greater disease burden than either condition alone
Pulmonology & Critical Care Sys. Review
COPD and OSA overlap syndrome is associated with greater disease burden than either condition alone Overlapping lung and sleep conditions lead to worse health outcomes
This narrative review examines the pathophysiological mechanisms and clinical outcomes of COPD-OSA overlap syndrome. The authors conclude th…
People with both chronic lung disease and sleep apnea face a heavier burden of illness than those with only one condition.
GLP-1 receptor agonists reduce apnea-hypopnea index by 15.28 events per hour in obstructive sleep apnea
Diabetes & Endocrinology Meta-analysis
GLP-1 receptor agonists reduce apnea-hypopnea index by 15.28 events per hour in obstructive sleep apnea GLP-1 receptor agonists show promise for obstructive sleep apnea
This network meta-analysis of 15 studies involving 1,877 participants found that GLP-1 receptor agonists significantly reduced the apnea-hyp…
New data suggests GLP-1 receptor agonists may reduce sleep apnea symptoms and improve oxygen levels in overweight or obese patients.
Aerobic exercise improves sleep outcomes in children and adolescents, but effect size uncertain
Pediatrics Meta-analysis
Aerobic exercise improves sleep outcomes in children and adolescents, but effect size uncertain Aerobic exercise may improve sleep for children and adolescents
This meta-analysis of randomized controlled trials found that aerobic exercise was associated with improved sleep-related outcomes in childr…
New data suggests that aerobic exercise can help kids and teens with sleep issues, though the consistency of these results varies.
Obstructive sleep apnea syndrome is associated with significantly higher blood pressure variability in patients
Rheumatology Meta-analysis
Obstructive sleep apnea syndrome is associated with significantly higher blood pressure variability in patients Sleep apnea is linked to higher blood pressure variability
This meta-analysis of 17 datasets involving 2,087 total participants found that individuals with obstructive sleep apnea syndrome (OSAS) exh…
People with obstructive sleep apnea show significantly more blood pressure fluctuations during the night and day compared to those without t…

Questions about sleep apnea

How accurate is machine learning at detecting sleep apnea from brain waves?

Machine learning can detect sleep apnea from brain waves with high accuracy, with pooled AUC around 0.95, though real-world performance varies.

Full answer →
Can machine learning use EEG signals to detect sleep apnea?

Yes, machine learning can use EEG signals to detect sleep apnea, with studies reporting high accuracy and AUC values.

Full answer →
Is robotic surgery an option for treating sleep apnea?

Yes, robotic surgery (TORS) is an option for sleep apnea when standard treatments fail, but it's not first-line and requires careful patient selection.

Full answer →