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Sleep apnea

Part of Sleep Disorders, Intrinsic

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for sleep apnea

48 trials tracked for sleep apnea: 1 in phase 3 or 4.

48Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 1 Phase 2 7 Phase 1 4 Other / NA 36
  1. Phase 3 Telemedicine Interventions for Obstructive Sleep Apnea (OSA) Completed
  2. Phase 2 Positional Therapy After Stroke Completed
  3. Phase 2 Chronic Evaluation of Respicardia Therapy Completed
  4. Phase 2 A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks Completed
  5. Phase 2 A Novel Pharmacological Therapy for Obstructive Sleep Apnea Completed
  6. Phase 2 A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults Completed
Show 42 more trials
  1. Phase 2 Dimethyl Fumarate for Obstructive Sleep Apnea Completed
  2. Phase 2 Effects of Treating Obstructive Sleep Apnea in Epilepsy Completed
  3. Phase 1 Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease? Completed
  4. Phase 1 Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036) Completed
  5. Phase 1 Pharmacodynamics and Efficacy of MK-7288 in Adults With Sleep Apnea (MK-7288-010) Completed
  6. Phase 1 Oxytocin on HR in Sleep Apnea Patient Completed
  7. N/A TatchSleep as a Tool to Aid in Sleep Apnea Analysis Completed
  8. N/A A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed
  9. N/A High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients Completed
  10. N/A Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy Completed
  11. N/A Mapping for Acute Transvenous Phrenic Nerve Stimulation Study Completed
  12. N/A Advancing Understanding of Transportation Options Completed
  13. N/A Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography Completed
  14. N/A Non-Inferiority Study of the FRESCA Mask Versus Existing CPAP Mask for Treatment of Obstructive Sleep Apnea Completed
  15. N/A Atrial Fibrillation Recurrence in Sleep Apnea Completed
  16. N/A Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep Completed
  17. N/A Treating Sleep Apnea in Women Veterans Completed
  18. N/A Diagnosis and Treatment of Sleep Apnea in the Acute Exacerbation of Heart Failure Completed
  19. N/A Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome Completed
  20. N/A Positive Airway Pressure for the Treatment of Asthma Completed
  21. N/A The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea Completed
  22. N/A A Validation Study of the NightOwl PAT-based Home Sleep Apnea Test Completed
  23. N/A Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea Completed
  24. N/A Non-Inferiority Study of the FRESCA Airbox Positive Airway Pressure System Completed
  25. N/A Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed
  26. N/A Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment Completed
  27. N/A Clinical Validation of New Commercial Sleep Monitoring Devices Completed
  28. N/A Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation Completed
  29. N/A Radiofrequency Ablation for Multi-level Obstructive Sleep Apnea: A Single-arm, Multicenter Study Completed
  30. N/A Tri Staple Technology Stapler Used in Gastric Bypass Completed
  31. N/A The Effects of Treating Obese and Lean Patients With Sleep Apnea Completed
  32. N/A Sleep Apnoea Breathing Record Exploratory Study (SABRES) Completed
  33. N/A Influence of Sleep Apnea on Risk of Atrial Fibrillation Completed
  34. N/A Estimating Apnea Phenotypes From Polysomnography: Oxygen Completed
  35. N/A Alice PDx User/Validation Extended Trial Completed
  36. N/A Modified AutoSet Device vs Existing AutoSet Device, the Assessment of Efficacy and Subjective Comfort of the Treatment. Completed
  37. N/A Long QT Syndrome and Sleep Apnea Completed
  38. N/A The Treatment of Insomnia Comorbid With Sleep Disordered Breathing Using Armodafinil and/or Cognitive Behavioral Therapy for Insomnia Completed
  39. N/A Addressing Insufficient PAP Use in Older Veterans Completed
  40. N/A Study Will Test the Theory That Training With the Facial-Flex Exercise Device Will Improve Snoring in Patients Completed
  41. N/A Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk Completed
  42. N/A Apnea Hypopnea Index Severity Versus Head Position During Sleep Completed

Showing the 48 most-cited and recently-updated of 48 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep apnea: what the trials found

Physical activity showed mixed results for sleep apnea outcomes. In one trial, changes in Epworth Sleepiness Scale score ranged from -2.62 to 0.43, and quality of life changes ranged from -0.33 to 1.24, with no significant differences reported 3.

A PAP adherence program significantly improved PAP adherence (2.16 vs 0.87, p=.0001) and daytime sleepiness (6.11 vs 7.59, p<0.001), but sleep quality was not significantly different (7.72 vs 8.01, p=0.378) 14.

The Apne-Scan DC1 device is a recent diagnostic tool for sleep apnea 2.

Supplemental oxygen is being investigated as a treatment for sleep apnea 1.

Atomoxetine is under investigation for sleep apnea 4.

Recent results — preliminary, needs further review

  • Supplemental oxygen is being explored as a potential treatment for sleep apnea 1.
  • The Apne-Scan DC1 device is a new diagnostic tool for sleep apnea 2.
  • Atomoxetine is under investigation for sleep apnea 4.
  • A PAP adherence program significantly improved PAP adherence and daytime sleepiness 14.
  • TatchSleep showed 89% agreement in AHI severity classification compared to polysomnography 15.

For the clinician treating this condition

  • PAP adherence programs can improve adherence and daytime sleepiness in sleep apnea patients 14.
  • Physical activity has mixed evidence for improving sleepiness and quality of life in sleep apnea 3.
  • New diagnostic tools like Apne-Scan DC1 and TatchSleep are emerging for sleep apnea assessment 215.

AI synthesis of 6 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Sleep Disorders, Intrinsic

Related studies from across the Sleep Disorders, Intrinsic family.

Intermittent hypoxia may disturb intestinal oxygen homeostasis and impair epithelial barrier function in obstructive sleep apnea
Pulmonology & Critical Care Sys. Review
Intermittent hypoxia may disturb intestinal oxygen homeostasis and impair epithelial barrier function in obstructive sleep apnea Sleep apnea may impact gut health and organ function
This narrative review explores how intermittent hypoxia (IH) impacts the gut microbiome and intestinal homeostasis in obstructive sleep apne…
New research explores how sleep apnea affects the gut and how microbes might play a role in heart and brain health.
Obstructive sleep apnea is associated with significant impairment of glymphatic transport via DTI-ALPS index
Neurology Meta-analysis
Obstructive sleep apnea is associated with significant impairment of glymphatic transport via DTI-ALPS index Sleep Disorders and the Brains Waste Removal System Impact on Health
This meta-analysis examines glymphatic-related metrics in patients with obstructive sleep apnea, sleep deprivation, and narcolepsy type 1. F…
New research shows that obstructive sleep apnea may damage the brain's waste cleaning system, potentially leading to long-term brain health …
Early adenotonsillectomy improves clinical outcomes in 65% of children with mild sleep-disordered breathing
Pediatrics RCT
Early adenotonsillectomy improves clinical outcomes in 65% of children with mild sleep-disordered breathing Early surgery improves quality of life for children with breathing issues
This randomized clinical trial of 363 children with mild sleep-disordered breathing found that early adenotonsillectomy (eAT) resulted in cl…
Early surgery for mild sleep-disordered breathing can significantly improve behavior and quality of life for children compared to watchful w…
GLP-1 receptor agonists reduce apnea-hypopnea index by 9.99 events per hour in obstructive sleep apnea
Diabetes & Endocrinology Meta-analysis
GLP-1 receptor agonists reduce apnea-hypopnea index by 9.99 events per hour in obstructive sleep apnea GLP-1 medications show promise for treating obstructive sleep apnea
This meta-analysis of 1069 adults with moderate-to-severe obstructive sleep apnea found that GLP-1 receptor agonists, including liraglutide …
New data suggests that GLP-1 medications like liraglutide and tirzepatide may help reduce sleep apnea symptoms and lower blood pressure.
One anastomosis gastric bypass provides durable weight loss and metabolic improvements over 15 years
Nutrition & Obesity Medicine Meta-analysis
One anastomosis gastric bypass provides durable weight loss and metabolic improvements over 15 years Gastric Bypass Shows Durable Weight Loss and Health Improvements
This meta-analysis of 1729 patients evaluates the long-term outcomes of one anastomosis gastric bypass (OAGB). The analysis indicates durabl…
Gastric bypass surgery can lead to lasting weight loss and improved conditions like diabetes and high blood pressure over 15 years.
Tonsillectomy with adjunctive pharyngoplasty or pillar suturing shows no significant difference in AHI for pediatric OSA
Pediatrics Meta-analysis
Tonsillectomy with adjunctive pharyngoplasty or pillar suturing shows no significant difference in AHI for pediatric OSA Adding extra surgery steps does not improve results for children's sleep apnea
This meta-analysis evaluated the efficacy of tonsillectomy with adjunctive pharyngoplasty or pillar suturing compared to tonsillectomy alone…
Adding extra surgical steps like pharyngoplasty does not improve outcomes for children with obstructive sleep apnea compared to standard ton…
Children with obstructive sleep apnea exhibit moderate neurocognitive deficits compared to healthy non-snoring controls
Pediatrics Meta-analysis
Children with obstructive sleep apnea exhibit moderate neurocognitive deficits compared to healthy non-snoring controls Sleep apnea in children is linked to lower cognitive scores
This meta-analysis of 436 children with polysomnographically confirmed obstructive sleep apnea found moderate neurocognitive deficits (Hedge…
Children with obstructive sleep apnea show moderate cognitive deficits in areas like memory and intelligence compared to healthy peers.
Obstructive sleep apnea is associated with higher blood T-tau and lower CSF amyloid-beta levels
Neurology Meta-analysis
Obstructive sleep apnea is associated with higher blood T-tau and lower CSF amyloid-beta levels Sleep Apnea Linked to Higher Alzheimer's Biomarkers in Blood
This meta-analysis examined Alzheimer's disease related biomarkers in patients with obstructive sleep apnea (OSA) compared to non-OSA contro…
New research shows that people with obstructive sleep apnea have higher levels of certain Alzheimer's markers in their blood and spinal flui…
TCCWTMS yields best sleep quality improvements among Tai Chi and Baduanjin for sleep disorders
Psychiatry Meta-analysis
TCCWTMS yields best sleep quality improvements among Tai Chi and Baduanjin for sleep disorders Tai Chi and Magnetic Stimulation Improve Sleep Quality
This network meta-analysis of 18 randomized controlled trials compared Tai Chi, Baduanjin, and TCCWTMS for sleep disorders. TCCWTMS showed t…
A review of 18 trials shows that combining Tai Chi with magnetic stimulation may offer the best results for improving sleep quality.
Sleep disturbances and obstructive sleep apnea lower seizure thresholds and impact sleep architecture in epilepsy
Neurology Sys. Review
Sleep disturbances and obstructive sleep apnea lower seizure thresholds and impact sleep architecture in epilepsy Sleep patterns and conditions impact seizure control in epilepsy
This narrative review explores the bidirectional relationship between epilepsy and sleep disorders. It highlights how NREM sleep promotes se…
New insights show how specific sleep stages and conditions like sleep apnea can influence seizure activity and quality of life for people wi…
AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection
Radiology & Imaging Meta-analysis
AI-based screening tools demonstrate high sensitivity and specificity for obstructive sleep apnea detection AI tools show promise for screening obstructive sleep apnea
This meta-analysis of 60 studies evaluated the diagnostic accuracy of AI-based screening tools for obstructive sleep apnea. The analysis fou…
New data shows AI tools can accurately identify obstructive sleep apnea, helping doctors find patients who need treatment more effectively.
Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk
Emergency Medicine Sys. Review
Obstructive sleep apnea is associated with a 2- to 3-fold increase in stroke risk Sleep disorders significantly impact recovery for stroke patients
This narrative review examines the prevalence and impact of sleep disorders, including obstructive sleep apnea (OSA), in stroke patients. Th…
Up to 84% of stroke patients suffer from sleep disorders, which can hinder recovery and increase the risk of future strokes.

Questions about sleep apnea

How accurate is machine learning at detecting sleep apnea from brain waves?

Machine learning can detect sleep apnea from brain waves with high accuracy, with pooled AUC around 0.95, though real-world performance varies.

Full answer →
Can machine learning use EEG signals to detect sleep apnea?

Yes, machine learning can use EEG signals to detect sleep apnea, with studies reporting high accuracy and AUC values.

Full answer →
Is robotic surgery an option for treating sleep apnea?

Yes, robotic surgery (TORS) is an option for sleep apnea when standard treatments fail, but it's not first-line and requires careful patient selection.

Full answer →