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Sleep apnea

Part of Sleep Disorders, Intrinsic

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for sleep apnea

48 trials tracked for sleep apnea: 1 in phase 3 or 4.

48Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 1 Phase 2 7 Phase 1 4 Other / NA 36
  1. Phase 3 Telemedicine Interventions for Obstructive Sleep Apnea (OSA) Completed
  2. Phase 2 Positional Therapy After Stroke Completed
  3. Phase 2 Chronic Evaluation of Respicardia Therapy Completed
  4. Phase 2 A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks Completed
  5. Phase 2 A Novel Pharmacological Therapy for Obstructive Sleep Apnea Completed
  6. Phase 2 A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults Completed
Show 42 more trials
  1. Phase 2 Dimethyl Fumarate for Obstructive Sleep Apnea Completed
  2. Phase 2 Effects of Treating Obstructive Sleep Apnea in Epilepsy Completed
  3. Phase 1 Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease? Completed
  4. Phase 1 Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036) Completed
  5. Phase 1 Pharmacodynamics and Efficacy of MK-7288 in Adults With Sleep Apnea (MK-7288-010) Completed
  6. Phase 1 Oxytocin on HR in Sleep Apnea Patient Completed
  7. N/A TatchSleep as a Tool to Aid in Sleep Apnea Analysis Completed
  8. N/A A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed
  9. N/A High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients Completed
  10. N/A Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy Completed
  11. N/A Mapping for Acute Transvenous Phrenic Nerve Stimulation Study Completed
  12. N/A Advancing Understanding of Transportation Options Completed
  13. N/A Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography Completed
  14. N/A Non-Inferiority Study of the FRESCA Mask Versus Existing CPAP Mask for Treatment of Obstructive Sleep Apnea Completed
  15. N/A Atrial Fibrillation Recurrence in Sleep Apnea Completed
  16. N/A Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep Completed
  17. N/A Treating Sleep Apnea in Women Veterans Completed
  18. N/A Diagnosis and Treatment of Sleep Apnea in the Acute Exacerbation of Heart Failure Completed
  19. N/A Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome Completed
  20. N/A Positive Airway Pressure for the Treatment of Asthma Completed
  21. N/A The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea Completed
  22. N/A A Validation Study of the NightOwl PAT-based Home Sleep Apnea Test Completed
  23. N/A Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea Completed
  24. N/A Non-Inferiority Study of the FRESCA Airbox Positive Airway Pressure System Completed
  25. N/A Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed
  26. N/A Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment Completed
  27. N/A Clinical Validation of New Commercial Sleep Monitoring Devices Completed
  28. N/A Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation Completed
  29. N/A Radiofrequency Ablation for Multi-level Obstructive Sleep Apnea: A Single-arm, Multicenter Study Completed
  30. N/A Tri Staple Technology Stapler Used in Gastric Bypass Completed
  31. N/A The Effects of Treating Obese and Lean Patients With Sleep Apnea Completed
  32. N/A Sleep Apnoea Breathing Record Exploratory Study (SABRES) Completed
  33. N/A Influence of Sleep Apnea on Risk of Atrial Fibrillation Completed
  34. N/A Estimating Apnea Phenotypes From Polysomnography: Oxygen Completed
  35. N/A Alice PDx User/Validation Extended Trial Completed
  36. N/A Modified AutoSet Device vs Existing AutoSet Device, the Assessment of Efficacy and Subjective Comfort of the Treatment. Completed
  37. N/A Long QT Syndrome and Sleep Apnea Completed
  38. N/A The Treatment of Insomnia Comorbid With Sleep Disordered Breathing Using Armodafinil and/or Cognitive Behavioral Therapy for Insomnia Completed
  39. N/A Addressing Insufficient PAP Use in Older Veterans Completed
  40. N/A Study Will Test the Theory That Training With the Facial-Flex Exercise Device Will Improve Snoring in Patients Completed
  41. N/A Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk Completed
  42. N/A Apnea Hypopnea Index Severity Versus Head Position During Sleep Completed

Showing the 48 most-cited and recently-updated of 48 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep apnea: what the trials found

Physical activity showed mixed results for sleep apnea outcomes. In one trial, changes in Epworth Sleepiness Scale score ranged from -2.62 to 0.43, and quality of life changes ranged from -0.33 to 1.24, with no significant differences reported 3.

A PAP adherence program significantly improved PAP adherence (2.16 vs 0.87, p=.0001) and daytime sleepiness (6.11 vs 7.59, p<0.001), but sleep quality was not significantly different (7.72 vs 8.01, p=0.378) 14.

The Apne-Scan DC1 device is a recent diagnostic tool for sleep apnea 2.

Supplemental oxygen is being investigated as a treatment for sleep apnea 1.

Atomoxetine is under investigation for sleep apnea 4.

Recent results — preliminary, needs further review

  • Supplemental oxygen is being explored as a potential treatment for sleep apnea 1.
  • The Apne-Scan DC1 device is a new diagnostic tool for sleep apnea 2.
  • Atomoxetine is under investigation for sleep apnea 4.
  • A PAP adherence program significantly improved PAP adherence and daytime sleepiness 14.
  • TatchSleep showed 89% agreement in AHI severity classification compared to polysomnography 15.

For the clinician treating this condition

  • PAP adherence programs can improve adherence and daytime sleepiness in sleep apnea patients 14.
  • Physical activity has mixed evidence for improving sleepiness and quality of life in sleep apnea 3.
  • New diagnostic tools like Apne-Scan DC1 and TatchSleep are emerging for sleep apnea assessment 215.

AI synthesis of 6 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Sleep Disorders, Intrinsic

Related studies from across the Sleep Disorders, Intrinsic family.

Prediabetes linked to 2.78-fold higher odds of obstructive sleep apnea in meta-analysis
Diabetes & Endocrinology Meta-analysis
Prediabetes linked to 2.78-fold higher odds of obstructive sleep apnea in meta-analysis Prediabetes Linked to Higher Risk of Obstructive Sleep Apnea
A meta-analysis of 8 cross-sectional studies (18,040 participants) found that prediabetes is associated with significantly higher prevalence…
A large review of data shows that people with prediabetes have a significantly higher risk of developing obstructive sleep apnea.
OSAS not significantly tied to diabetic retinopathy overall, but risk doubles in Asian subgroups
Diabetes & Endocrinology Meta-analysis
OSAS not significantly tied to diabetic retinopathy overall, but risk doubles in Asian subgroups Sleep Apnea Link to Diabetic Retinopathy Varies by Region
This meta-analysis of 599,405 patients with type 2 diabetes found no significant overall association between obstructive sleep apnea syndrom…
New data suggests that the link between sleep apnea and eye damage in people with type 2 diabetes depends on location and testing methods.
AI-oximetry models show 91.1% sensitivity and 88.4% specificity for obstructive sleep apnea diagnosis
Radiology & Imaging Meta-analysis
AI-oximetry models show 91.1% sensitivity and 88.4% specificity for obstructive sleep apnea diagnosis AI models show high accuracy in diagnosing obstructive sleep apnea
This meta-analysis of 23,171 patients evaluated AI models trained on pulse oximetry readings for diagnosing obstructive sleep apnea (OSA). T…
New analysis shows AI tools using pulse oximetry can accurately identify sleep apnea, offering a faster way to screen patients in clinics.
Overweight and obesity prevalence in individuals with Down syndrome reaches 22% across mixed-age cohorts
Diabetes & Endocrinology Meta-analysis
Overweight and obesity prevalence in individuals with Down syndrome reaches 22% across mixed-age cohorts Overweight and Obesity Rates are High Among People with Down Syndrome
This meta-analysis of 26 studies involving 7,840 individuals identifies a high prevalence of overweight and obesity in people with Down synd…
New data shows that overweight and obesity rates are significantly higher in people with Down syndrome compared to the general population.
Combined exercise modalities show highest probability of effectiveness for adolescent sleep disorders
Primary Care & Family Medicine Meta-analysis
Combined exercise modalities show highest probability of effectiveness for adolescent sleep disorders Combined exercises may improve sleep disorders in Chinese adolescents
This systematic review and network meta-analysis of 1,375 Chinese adolescents indicates that combined aerobic and mind-body exercise (AE + M…
Combining aerobic and mind-body exercises could offer a more effective way to help teenagers struggling with sleep disorders.
Predictors of Polysomnography Progression in Children with Mild Sleep-Disordered Breathing
Pediatrics RCT
Predictors of Polysomnography Progression in Children with Mild Sleep-Disordered Breathing Certain risk factors may signal when children need surgery sooner
Identifying specific risk factors like ADHD and asthma can help clinicians determine which children with mild sleep-disordered breathing req…
New data shows that conditions like asthma and ADHD can make it more likely that a child's snoring and breathing issues will worsen over tim…
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63
Primary Care & Family Medicine Meta-analysis
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63 Mind-body therapies improve sleep quality for perinatal women
This systematic review and meta-analysis of 13 randomized controlled trials involving 782 participants found that mindfulness, Pilates, and …
Yoga, Pilates, and mindfulness may offer a helpful way for pregnant and new mothers to improve their sleep quality during a demanding time.
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
Pulmonology & Critical Care Meta-analysis
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds 1 in 7 COPD patients decline or stop breathing therapy
This systematic review and meta-analysis of patients with COPD newly prescribed long-term noninvasive positive airway pressure (PAP) therapy…
A new analysis finds 14% of COPD patients decline or stop long-term breathing therapy, often within six weeks.
NIV with total face mask managed acute respiratory failure in two patients with Madelung's disease and COVID-19 pneumonia
Rheumatology Sys. Review
NIV with total face mask managed acute respiratory failure in two patients with Madelung's disease and COVID-19 pneumonia Non-invasive ventilation may help patients with Madelung's disease and respiratory failure
This case series describes non-invasive ventilation using a total face mask in two patients with Madelung's disease who experienced acute re…
A small case series suggests non-invasive ventilation can manage acute respiratory failure in patients with Madelung's disease, though more …
Team sports may improve sleep quality but evidence is inconsistent and limited
Psychiatry Meta-analysis
Team sports may improve sleep quality but evidence is inconsistent and limited Team sports may improve sleep quality in young people
This systematic review of 809 participants across diverse populations found that team sports such as football and basketball may improve sle…
A review of studies suggests team sports like football and volleyball could help improve sleep for adolescents, students, and athletes, but …
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients
Cardiology Meta-analysis
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients Renal denervation may help resistant hypertension patients with heart issues
This systematic review and meta-analysis evaluated renal denervation in patients with resistant hypertension. The pooled analysis included 8…
A meta-analysis suggests renal denervation improves heart and sleep markers in patients with resistant hypertension, though larger trials ar…
Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients
ENT (Otolaryngology) Meta-analysis
Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients Radiation for head and neck cancer may raise sleep apnea risk
This scoping review with exploratory meta-analysis of 13 studies found no significant association between radiotherapy or chemotherapy and i…
A review of 13 studies suggests a possible link between radiation for head and neck cancer and mild sleep apnea, but the evidence is too wea…