Phase 1
Completed N=45
A Study of the Effects of Oral Prednisone in Patients With Rheumatoid Arthritis (MK0000-088)
Source: ClinicalTrials.gov NCT00746512 ↗Enrolled (actual)
45
Serious AEs
2.2%
Results posted
Apr 2011
Primary outcomePrimary: Synovial Blood Flow — 9.48; 10.55; 8.31; 9.78 pixel count
Summary
The study will compare the effects of prednisone vs placebo on synovial blood flow and overall DAS (disease activity score) in patients with rheumatoid arthritis.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Synovial Blood Flow |
9.48; 10.55; 8.31; 9.78; 6.52; 13.37 | — |
| SECONDARY Disease Activity Score 28 (DAS28) (C-reactive Protein [CRP]) |
5.17; 5.45; 5.31; 5.62; 3.57; 5.04 | — |
Eligibility Criteria
Inclusion Criteria
- Patient is willing to limit alcohol intake to 3 or less beverages per day
- Patient agrees to use only acetaminophen/paracetamol for breakthrough pain
Exclusion Criteria
- Patient has other inflammatory arthritis (e.g. lupus). Patient has had major surgery or donated or lost 1 unit of blood in the last 4 weeks
- Patient has a history of drug or alcohol abuse in the last 2 years
- Patient has had a vaccine (with a live or attenuated virus) in the last two weeks
Data sourced from ClinicalTrials.gov (NCT00746512). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.