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N/A N=75 Randomized Single-blind Basic Science

Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction

Acute Myocardial Infarction

Bottom Line

View on ClinicalTrials.gov: NCT00755131 ↗
Enrolled (actual)
75
Serious AEs
0.0%
Results posted
Jan 2010
Primary outcome: Primary: High Mobility Group Box-1 (HMGB1)Levels at Baseline and 6 Months — 27.6; 24.5; 11.7; 20.5 ng/ml — p=<0.05

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Exercise-based Cardiac Rehabilitation program (Other)
Age
Adult, Older Adult · 35+ yrs
Sex
All
Sponsor
Federico II University
Primary completion
Jun 2009

Outcome Measures

OutcomeResultp-value
PRIMARY
High Mobility Group Box-1 (HMGB1)Levels at Baseline and 6 Months		 27.6; 24.5; 11.7; 20.5 <0.05 sig
SECONDARY
Peak Oxygen Consumption (VO2peak) at Baseline and 6 Months		 16.4; 16.7; 21.0; 16.3 <0.05 sig

Summary

This purpose of this study is to examine the relationship between HMGB-1 and postinfarction predictors of outcome such as cardiopulmonary and echocardiographic parameters before and after a 6-month exercise-based cardiac rehabilitation program.

Eligibility Criteria

Inclusion Criteria

  • Acute Myocardial Infarction

Exclusion Criteria

  • BMI higher than 30 and lower than 18
  • Residual myocardial ischemia
  • Severe ventricular arrhythmias
  • IIb or III degree atrio-ventricular block
  • Valvular disease requiring surgery
  • Pericarditis
  • Severe renal dysfunction (i.e. creatinine >2.5 mg/dl)
  • Severe concomitant non-cardiac disease such as cancer
  • Liver dysfunction (alanine aminotransferase/aspartate aminotransferase level >1.5 times the upper normal limit)
  • Dementia
  • Any systemic disease limiting exercise
  • Inability to participate in a prospective study for any logistic reason
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00755131). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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