N/A
Completed N=75
Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction
Source: ClinicalTrials.gov NCT00755131 ↗Enrolled (actual)
75
Serious AEs
0.0%
Results posted
Jan 2010
Primary outcomePrimary: High Mobility Group Box-1 (HMGB1)Levels at Baseline and 6 Months — 27.6; 24.5; 11.7; 20.5 ng/ml — p=<0.05
Summary
This purpose of this study is to examine the relationship between HMGB-1 and postinfarction predictors of outcome such as cardiopulmonary and echocardiographic parameters before and after a 6-month exercise-based cardiac rehabilitation program.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY High Mobility Group Box-1 (HMGB1)Levels at Baseline and 6 Months |
27.6; 24.5; 11.7; 20.5 | <0.05 sig |
| SECONDARY Peak Oxygen Consumption (VO2peak) at Baseline and 6 Months |
16.4; 16.7; 21.0; 16.3 | <0.05 sig |
Eligibility Criteria
Inclusion Criteria
- Acute Myocardial Infarction
Exclusion Criteria
- BMI higher than 30 and lower than 18
- Residual myocardial ischemia
- Severe ventricular arrhythmias
- IIb or III degree atrio-ventricular block
- Valvular disease requiring surgery
- Pericarditis
- Severe renal dysfunction (i.e. creatinine >2.5 mg/dl)
- Severe concomitant non-cardiac disease such as cancer
- Liver dysfunction (alanine aminotransferase/aspartate aminotransferase level >1.5 times the upper normal limit)
- Dementia
- Any systemic disease limiting exercise
- Inability to participate in a prospective study for any logistic reason
Data sourced from ClinicalTrials.gov (NCT00755131). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.