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Home › Conditions › Myocardial Infarction

Myocardial Infarction

Part of Myocardial ischemia

45 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Myocardial Infarction

139 trials tracked for Myocardial Infarction: 55 in phase 3 or 4 and 20 with published results. The most-cited published study has 2930 citations.

139Trials tracked
55Phase 3 & 4
0Recruiting
20With published results
Phase distribution
Phase 4 20 Phase 3 35 Phase 2 22 Other / NA 62
  1. Phase 3 Colchicine Cardiovascular Outcomes Trial (COLCOT) Completed · 2,930 cited
  2. Phase 3 Secondary Prevention of Cardiovascular Disease in the Elderly Trial Completed · 314 cited
  3. Phase 3 Interleukin-1 (IL-1) Blockade in Acute Myocardial Infarction (VCU-ART3) Completed · 285 cited
  4. Phase 3 Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction Completed · 284 cited
  5. Phase 3 Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack. Completed · 267 cited
  6. Phase 3 EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction) Completed · 252 cited
Show 44 more trials
  1. Phase 4 Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction Completed · 183 cited
  2. Phase 3 Effect of High Dose Fish Oil Supplementation After Recent Heart Attack Using Magnetic Resonance Imaging Completed · 170 cited
  3. Phase 4 INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure Completed · 129 cited
  4. Phase 3 Insulin Resistance Intervention After Stroke Trial Completed · 108 cited
  5. Phase 4 Subclinical Cardiovascular Disease in Psoriatic Disease Completed · 95 cited
  6. Phase 3 Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Completed · 57 cited
  7. Phase 4 STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction Completed · 53 cited
  8. Phase 3 Glutamate for Metabolic Intervention in Coronary Surgery Completed · 46 cited
  9. Phase 3 Trial to Assess Chelation Therapy 2 Completed · 23 cited
  10. Phase 4 Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor Completed · 22 cited
  11. Phase 4 Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus Completed · 19 cited
  12. Phase 3 Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI Completed · 16 cited
  13. Phase 3 STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction Completed · 7 cited
  14. Phase 3 Myocardial Ischemia and Transfusion Completed · 7 cited
  15. Phase 4 Alirocumab in Patients With Acute Myocardial Infarction Completed
  16. Phase 4 Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction Completed
  17. Phase 4 Vorapaxar on Thrombin Generation and Coagulability Completed
  18. Phase 4 Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization Completed
  19. Phase 4 CES1 Crossover Trial of Clopidogrel and Ticagrelor Completed
  20. Phase 4 Effects of N-acetylcysteine on Low T3 Syndrome Completed
  21. Phase 4 Intravenous Exenatide in Coronary Intensive Care Unit (ICU) Patients Completed
  22. Phase 4 APRICOT-3: Antithrombotics in the Prevention of Reocclusion In COronary Thrombolysis -3 Completed
  23. Phase 4 Comparison Between Thrombolysis and Primary Percutaneous Coronary Intervention (PCI) to Treat ST-Segment Elevation Myocardial Infarction Completed
  24. Phase 4 Hyperglycemia and Cardiovascular Outcomes With Type 2 Diabetes Completed
  25. Phase 4 Efficacy of Everolimus-Eluting Versus Zotarolimus-Eluting Sten for Coronary Lesions in Acute Myocardial Infarction Completed
  26. Phase 4 A 30 Day Study to Evaluate Efficacy and Safety of Pre-hospital vs. In-hospital Initiation of Ticagrelor Therapy in STEMI Patients Planned for Percutaneous Coronary Intervention (PCI) Completed
  27. Phase 4 Pilot Study of Edaravone to Treat Acute Myocardial Infarction Completed
  28. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Heart Disease Completed
  29. Phase 3 Single Bolus Recombinant Nonimmunogenic Staphylokinase Versus Single Bolus Tenecteplase (Metalyse) in STEMI Completed
  30. Phase 3 SPECTACL: SPECTroscopic Assessment of Coronary Lipid Completed
  31. Phase 3 Omega-3 Fatty Acids to Improve Depression and Reduce Cardiovascular Risk Factors Completed
  32. Phase 3 Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease Completed
  33. Phase 3 Myocardial Ischemia and Transfusion Pilot Completed
  34. Phase 3 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed
  35. Phase 3 Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial Completed
  36. Phase 3 Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183) Completed
  37. Phase 3 Multicenter Study to Rule Out Myocardial Infarction by Cardiac Computed Tomography Completed
  38. Phase 3 Occluded Artery Trial (OAT) Completed
  39. Phase 3 IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium. Completed
  40. Phase 3 IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) Completed
  41. Phase 3 Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737) Completed
  42. Phase 3 An Efficacy and Safety Study for Rivaroxaban in Patients With Acute Coronary Syndrome Completed
  43. Phase 3 Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin Completed
  44. Phase 3 Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer Completed

Showing the 50 most-cited and recently-updated of 139 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Individualized six-phase antithrombotic strategy leads to left ventricular thrombus resolution and neurological recovery
Drug Pipeline Guideline
Individualized six-phase antithrombotic strategy leads to left ventricular thrombus resolution and neurological recovery New strategy helps manage heart blood clots after heart attack
This case report describes an individualized six-phase antithrombotic strategy for a 27-year-old male with myocardial infarction, stroke, hy…
A tailored six-phase treatment plan helped a young man recover fully from a stroke and heart attack while successfully clearing dangerous bl…
Frontiers Jun 13, 2026
Current literature lacks research on myocardial infarction warning signs within transgender and gender diverse populations in the United States
Primary Care & Family Medicine Sys. Review
Current literature lacks research on myocardial infarction warning signs within transgender and gender diverse populations in the United States No clear guide exists for transgender heart attack warning signs in the United States
A brief review highlights a critical gap in understanding heart attack symptoms for transgender and gender diverse individuals. More researc…
A review found no current research on heart attack warning signs for transgender people, leaving them without standard heart health educatio…
Frontiers Jun 5, 2026
Polygenic scores link to atherosclerosis and ischemic heart disease in Russian populations
Cardiology Meta-analysis
Polygenic scores link to atherosclerosis and ischemic heart disease in Russian populations Genetic markers help predict heart disease risk for Russian men and women
This meta-analysis review examines genetic predictors of atherosclerosis, ischemic heart disease, and myocardial infarction in a Russian pop…
A large study found specific genes linked to cholesterol levels in Russian people. These genetic scores can help doctors check heart disease…
Frontiers Jun 2, 2026
Baduanjin exercise practice improves outcomes for patients with acute myocardial infarction undergoing percutaneous coronary intervention procedures
Cardiology Meta-analysis
Baduanjin exercise practice improves outcomes for patients with acute myocardial infarction undergoing percutaneous coronary intervention procedures Baduanjin exercise improves heart recovery and mood after heart attack surgery
A systematic review and meta-analysis of 1,293 patients with acute myocardial infarction undergoing percutaneous coronary intervention found…
A meta-analysis shows Baduanjin exercise improved heart function, walking distance, and mood in patients recovering from heart attacks and s…
Jun 1, 2026
Docetaxel chemotherapy is highly suspect for causing acute myocardial infarction in a low-risk triple-negative breast cancer patient
Cardiology Sys. Review
Docetaxel chemotherapy is highly suspect for causing acute myocardial infarction in a low-risk triple-negative breast cancer patient Docetaxel chemotherapy linked to rare heart attack in breast cancer patient
This case report and literature review examines acute myocardial infarction following docetaxel chemotherapy in a patient with triple-negati…
A rare heart attack occurred after docetaxel chemotherapy in a patient with triple-negative breast cancer. This case review suggests the dru…
Frontiers May 29, 2026
Serum resistin levels rise progressively with worsening severity of coronary heart disease and acute myocardial infarction in this meta-analysis
Cardiology Meta-analysis
Serum resistin levels rise progressively with worsening severity of coronary heart disease and acute myocardial infarction in this meta-analysis High blood resistin levels linked to heart disease severity in large analysis
A network meta-analysis of 9,169 subjects reveals that serum resistin levels increase stepwise as coronary heart disease severity worsens. W…
A large network meta-analysis found that higher serum resistin levels are linked to worse coronary heart disease and acute heart attacks.
Frontiers May 28, 2026
Review of immunomodulatory strategies for myocardial infarction notes major translational gaps and undefined heart-immune axis
Cardiology Sys. Review
Review of immunomodulatory strategies for myocardial infarction notes major translational gaps and undefined heart-immune axis New ideas for heart attack treatment face big scientific hurdles
This review examines immunomodulatory strategies targeting the CCR2/CCL2 axis, regulatory T cells, and macrophage polarization compared to c…
Experts review new immune-targeting strategies for heart attacks but note major gaps in understanding how the heart and immune system intera…
Frontiers May 28, 2026
Breast arterial calcification linked to increased cardiovascular mortality risk
Radiology & Imaging Meta-analysis
Breast arterial calcification linked to increased cardiovascular mortality risk Calcified breast arteries linked to higher risk of heart disease and death
This meta-analysis examined associations between breast arterial calcification and cardiovascular outcomes. The authors observed that the pr…
A large analysis shows breast arterial calcification is associated with higher risks of heart failure, stroke, and death in women.
May 26, 2026
Network meta-analysis of oral Chinese patent medicines for myocardial infarction with heart failure
Cardiology Meta-analysis
Network meta-analysis of oral Chinese patent medicines for myocardial infarction with heart failure Four Chinese medicines show promise for heart failure after heart attack
This network meta-analysis evaluated oral Chinese patent medicines combined with conventional treatment in patients with myocardial infarcti…
A network meta-analysis of 42 trials found four oral Chinese patent medicines improved outcomes when added to standard heart failure treatme…
Frontiers May 21, 2026
Narrative review discusses iron-dependent ferroptosis in cardiac microvascular endothelial cells during myocardial ischemia-reperfusion
Cardiology Sys. Review
Narrative review discusses iron-dependent ferroptosis in cardiac microvascular endothelial cells during myocardial ischemia-reperfusion Iron overload damages heart vessels and blocks blood flow after a heart attack
This narrative review examines the role of iron-dependent ferroptosis and dysregulated iron homeostasis in cardiac microvascular endothelial…
Doctors now see that iron overload inside heart cells blocks blood flow even when major arteries are open
Frontiers May 7, 2026
Individual patient data meta-analysis links myocardial injury categories to cardiovascular event risk
Cardiology Meta-analysis
Individual patient data meta-analysis links myocardial injury categories to cardiovascular event risk Heart Attack Risk: New Classification Changes Everything for Patients
This individual patient-level data meta-analysis of 120,734 patients from 9 countries evaluated myocardial injury and infarction categories.…
A new way of classifying heart attacks reveals that patients with type 2 heart attacks face a surprisingly higher risk of dying from non-hea…
May 6, 2026
Beta-blocker therapy in AMI patients with preserved ejection fraction shows comparable outcomes to non-use
Cardiology Meta-analysis
Beta-blocker therapy in AMI patients with preserved ejection fraction shows comparable outcomes to non-use New analysis shows beta-blockers do not lower heart attack risks for most patients with strong hearts
This meta-analysis of randomized controlled trials evaluated beta-blocker therapy in 19,826 patients with acute myocardial infarction and pr…
A large study of nearly twenty thousand patients found that taking beta-blockers after a heart attack did not reduce the risk of dying or ha…
May 3, 2026

Research across Myocardial ischemia

Related studies from across the Myocardial ischemia family.

Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients
Cardiology Meta-analysis
Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients Timing of heart surgery does not change survival for a specific heart attack group
This meta-analysis reviewed 5077 patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease comparing …
A large review found that waiting for staged heart surgery did not improve survival or reduce heart attacks compared to immediate surgery fo…
Jun 1, 2026
Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease
Cardiology RCT
Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease
This Bayesian re-analysis of a randomized trial evaluated complete versus culprit-only revascularization in patients with non-ST-elevation m…
A Bayesian re-analysis suggests complete revascularization offers a high probability of clinically meaningful benefit compared to treating o…
Jun 1, 2026
Prehospital unfractionated heparin bolus improved TIMI flow in STEMI without increasing bleeding risk
Cardiology RCT
Prehospital unfractionated heparin bolus improved TIMI flow in STEMI without increasing bleeding risk Pretreatment with UFH improves artery flow for STEMI patients without extra bleeding risk
This single-center randomized trial evaluated pretreatment with unfractionated heparin in patients with ST-segment-elevation myocardial infa…
Giving unfractionated heparin early at first medical contact improved artery flow in heart attack patients without increasing bleeding risk.
May 19, 2026
Case report and review of literature on acute NSTEMI after fluorescein angiography in a 76-year-old woman
Ophthalmology Sys. Review
Case report and review of literature on acute NSTEMI after fluorescein angiography in a 76-year-old woman Rare heart attack possible after fluorescein angiography in older adults with heart disease
This case report and review of the literature describes a 76-year-old woman with hypertension, hyperlipidemia, and type 2 diabetes mellitus …
A 76-year-old woman with heart disease had a heart attack shortly after a dye test, highlighting rare risks.
Frontiers May 18, 2026
Meta-analysis shows no significant difference between immediate and staged revascularization for STEMI with multivessel disease
Cardiology Meta-analysis
Meta-analysis shows no significant difference between immediate and staged revascularization for STEMI with multivessel disease Immediate heart procedure shows no major benefit over staged approach for heart attack patients
This systematic review and meta-analysis evaluated patients with ST-elevation myocardial infarction and multivessel disease undergoing immed…
A large review of heart attack patients with multiple blocked arteries found that doing the full procedure right away did not lower the risk…
May 15, 2026
Family history, prior arrhythmia, and anterior infarct location independently raise risk of ventricular fibrillation in STEMI patients
Cardiology Meta-analysis
Family history, prior arrhythmia, and anterior infarct location independently raise risk of ventricular fibrillation in STEMI patients Family history and heart attack location raise risk of dangerous heart rhythms in young patients
This meta-analysis of 1807 cases and 2923 controls confirms that family history of sudden death, previous atrial fibrillation, and anterior …
A large study found that family history of sudden death, past atrial fibrillation, and front heart attacks increase the chance of dangerous …
May 2, 2026
Meta-analysis finds invasive therapy reduces MI and revascularization in elderly NSTEMI patients
Cardiology Meta-analysis
Meta-analysis finds invasive therapy reduces MI and revascularization in elderly NSTEMI patients Older Heart Attack Patients Do Better With Stents But Face Bleeding Risks
This systematic review and meta-analysis of 2997 elderly patients with NSTEMI found that invasive therapies, compared with medical therapy, …
New data shows stents help older heart attack patients avoid repeat events but do not lower overall death rates compared to medicine alone.
May 1, 2026
Rescue PCI after failed fibrinolysis linked to worse outcomes in STEMI compared to scheduled angiography
Cardiology RCT
Rescue PCI after failed fibrinolysis linked to worse outcomes in STEMI compared to scheduled angiography Rescue PCI after failed clot-busting drugs caused worse heart outcomes than planned angiography
This pre-specified analysis of the STREAM-2 RCT compared rescue PCI after failed fibrinolysis with scheduled angiography in 583 patients wit…
Patients needing emergency heart catheterization after clot-busting drugs fared worse than those who received planned procedures, with highe…
Apr 29, 2026
Sirolimus-eluting iron bioresorbable scaffold shows higher late lumen loss than everolimus-eluting stents in coronary artery disease patients
Cardiology RCT
Sirolimus-eluting iron bioresorbable scaffold shows higher late lumen loss than everolimus-eluting stents in coronary artery disease patients New iron scaffold matches metal stents for heart artery repair
This randomized trial enrolled 518 patients with myocardial ischemia and 1 or 2 de novo target lesions at 36 centers in China.
A new iron heart scaffold matches metal stents in safety and effectiveness while dissolving over time.
Apr 29, 2026
Narrative review covers cardiovascular conditions and cognitive decline without reported trial data
Cardiology Sys. Review
Narrative review covers cardiovascular conditions and cognitive decline without reported trial data Your Heart and Brain Are Talking to Each Other
This narrative review addresses a broad scope of cardiovascular conditions, including stroke, heart failure, atrial fibrillation, and ischem…
Imagine your heart and brain as two best friends who never stop texting each other.
Frontiers Apr 22, 2026
Intracoronary nicorandil improves TIMI flow and reduces AMR in STEMI patients undergoing primary PCI
Cardiology Cohort
Intracoronary nicorandil improves TIMI flow and reduces AMR in STEMI patients undergoing primary PCI New Drug Opens Tiny Vessels After Heart Attack Treatment
This single-center randomized trial enrolled 63 patients with first-episode ST-segment elevation myocardial infarction undergoing primary PC…
A new drug given during heart surgery may help blood flow reach the heart muscle better.
Frontiers Apr 22, 2026
In STEMI patients, admission CK-MB and CPK elevation predicts adverse outcomes in a small cross-sectional study
Cardiology Cohort
In STEMI patients, admission CK-MB and CPK elevation predicts adverse outcomes in a small cross-sectional study Old Heart Tests Still Save Lives
This cross-sectional study evaluated 15 patients with ST-elevation myocardial infarction (STEMI) at the Punjab Institute of Cardiology, Laho…
Imagine waking up with crushing chest pain.
medRxiv Apr 22, 2026

Questions about Myocardial Infarction

Will a special breathing machine help if I have sleep problems after my heart attack?

Yes, a special breathing machine (ASVmv) can reduce nighttime oxygen drops in heart attack patients with sleep-disordered breathing, but it's not a standard treatment for all sleep problems after a heart attack.

Full answer →
Can I choose between moderate or high-intensity exercise to recover from my heart attack?

Both moderate and high-intensity exercise similarly improve heart function after a heart attack, but you should start with moderate intensity and get your doctor's approval before increasing intensity.

Full answer →
Does my kidney number creatinine level affect my risk after a heart attack procedure?

Yes, higher creatinine levels are linked to a greater risk of adverse events after a heart attack procedure, especially if you also have anemia.

Full answer →
How do artificial intelligence tools compare to doctors for predicting heart attack biomarkers?

AI tools can match or slightly outperform doctors in predicting heart attack biomarkers, but most studies lack real-world validation.

Full answer →
Do beta-blockers reduce my risk of death if my heart function is normal after MI?

For patients with normal heart function after MI, beta-blockers do not appear to reduce the risk of death or recurrent heart attack based on recent large trials.

Full answer →
Does having a specific type of myocardial injury increase my risk of future heart events?

Yes, the type of myocardial injury matters: type 1 MI carries the highest risk of future heart events, but type 2 MI and acute/chronic myocardial injury also increase risk compared to no injury.

Full answer →
See all 6 questions about Myocardial Infarction →

All Myocardial Infarction Articles