N/A
Completed N=101
Heparin and the Reduction of Thrombosis (HART) Trial
Source: ClinicalTrials.gov NCT00779558 ↗Enrolled (actual)
101
Serious AEs
0.0%
Results posted
Jun 2015
Primary outcomePrimary: Thrombosis — 8; 6 participants
Summary
Heparin is frequently used in central venous catheters (CVCs) in post-operative cardiac patients. It remains unclear if a heparin infusion, compared to a normal saline infusion, prevents thrombosis of CVCs after surgery. This study will answer the question: does a low-dose heparin infusion (10 units/kg/h) prevent thrombosis, compared to a normal saline infusion, in patients less than one year of age after cardiac surgery?
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Thrombosis |
8; 6 | — |
| SECONDARY Total PRBCs Transfused |
8.8; 5.6 | — |
| SECONDARY Days to Extubation |
3.5; 3.3 | — |
| SECONDARY Cardiac ICU Length of Stay |
10; 6.9 | — |
| SECONDARY Need for Antibiotics |
14; 9 | — |
Eligibility Criteria
Inclusion Criteria
- All infants < 1 year of age undergoing cardiac surgery at Lucile Packard Children's Hospital & #xA
Exclusion Criteria
- Known coagulopathy
- History of clinically significant bleeding (GI, cranial, pulmonary)
- Need for therapeutic heparinization
- ECMO
Data sourced from ClinicalTrials.gov (NCT00779558). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.