Phase 2 Completed N=10 Other

Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla

Type 1 Diabetes

Source: ClinicalTrials.gov NCT00786825 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2019

Primary outcomePrimary: Brain Glycogen Turnover Rate — 0.31; 0.28 mg/kg/min

Summary

The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism in humans. We will measure brain glycogen turnover and content in normal controls and subjects with diabetes under conditions of modest hyper-and hypoglycemia.

Outcome Measures

Outcome	Result	p-value
PRIMARY Brain Glycogen Turnover Rate	0.31; 0.28	—

Eligibility Criteria

Inclusion Criteria

Age 18-65
Healthy control
Must be able to provide informed consent
Type 1 diabetes with hypoglycemia unawareness with hemoglobin A1c 7.5%
Subjects with hypoglycemia unawareness must report an inability to recognize at least some blood glucose values <58 mg/dL during the 3 months prior to the study.

Exclusion Criteria

Over 300 pounds
Claustrophobic
History of ischemic heart disease, arrhythmia, of seizure disorder
Pregnant
On medications known to alter blood flow or carbohydrate metabolism
Have internally located pieces of metal

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00786825). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.