N/A N=7 Randomized Quadruple-blind Basic Science

Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)

Glaucoma

Bottom Line

View on ClinicalTrials.gov: NCT00824824 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2016

Primary outcome: Primary: Presence of Retinal Vascular Dysregulation (RVD) — 7; 4 Participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Dorzolamide 2%-timolol 0.5% (Drug); Brimonidine 0.2%-0.5% timolol 0.5 (Drug)
Age: Adult, Older Adult · 40+ yrs
Sex: All
Sponsor: Massachusetts Eye and Ear Infirmary
Primary completion: Aug 2012

Outcome Measures

Outcome	Result	p-value
PRIMARY Presence of Retinal Vascular Dysregulation (RVD)	7; 4	—

Summary

We have completed a study in which we examined the response of the retinal circulation to changes in posture from sitting to lying down in patients with primary open angle glaucoma (POAG). This alteration in position produces changes in the local blood pressure at the entrance to the retinal vasculature. In a healthy retina, the vasculature adapts by dilating and constricting in order to maintain a steady blood flow rate. In an eye with POAG, this often does not occur. As a result, there are large fluctuations in blood flow which may produce the retinal neuronal damage associated with glaucoma. The purpose of this study is to demonstrate that topical anti-glaucoma treatments with agents that have vasoactive as well as IOP-lowering effects can have a beneficial effect on maintaining a steady retinal blood flow rate even when there are changes in local blood pressure.

Eligibility Criteria

Inclusion Criteria

POAG
Age 40 to 80 years
Untreated IOP greater than 21 mm Hg

Exclusion Criteria

More than two IOP lowering medications
Exfoliation or pigment dispersion syndrome
Diabetic retinopathy
History of ocular surgery

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00824824). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.