N/A
Completed N=25
Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia
Source: ClinicalTrials.gov NCT00833547 ↗Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Sep 2014
Primary outcomePrimary: Overnight Change on Finger Tapping Task — 21; 2 percent change
Summary
This study will determine whether eszopiclone will normalize sleep patterns and restore sleep-dependent enhancement of motor skill learning in patients with schizophrenia. The investigators will compare subjects taking a placebo to those taking 3 mg of eszopiclone with regard to: sleep architecture and sleep latency as measured by actigraphy and polysomnography and sleep-dependent motor skill learning.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Overnight Change on Finger Tapping Task |
21; 2 | — |
| PRIMARY Sleep Spindle Density During Stage 2 Sleep as Measured by Polysomnography |
1.76; 1.07 | — |
Eligibility Criteria
Inclusion Criteria
- Clinically stable outpatients with DSM-IV diagnoses of Schizophrenia
Exclusion Criteria
- History of neurologic or psychiatric disease other than schizophrenia
- Substance abuse or dependence within the past six months
- Other chronic medical conditions that affect sleep
- Pregnancy/breast feeding
- Hepatic impairment
- Treatment with metabolic inhibitors or inducers
Data sourced from ClinicalTrials.gov (NCT00833547). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.