Phase 2
N=19
Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor
Essential Tremor
Bottom Line
View on ClinicalTrials.gov: NCT00848172 ↗Enrolled (actual)
19
Serious AEs
3.6%
Results posted
Dec 2012
Primary outcome: Primary: Normalized Accelerometric Tremor Power, Dominant Hand, 80min After Administration, Weighted Condition — 0.669; 0.798 ratio — p==0.345
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Octanoic Acid (Drug); Placebo (Drug)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
- Primary completion
- Nov 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Normalized Accelerometric Tremor Power, Dominant Hand, 80min After Administration, Weighted Condition |
0.669; 0.798 | =0.345 |
| SECONDARY Normalized Tremor Power, 300 Min After Administration, Weighted Condition, Dominant Hand, OA vs Placebo |
0.689; 1.071 | =0.031 sig |
| SECONDARY TMax Octanoic Acid |
72.8 | — |
| SECONDARY PK: AUC After OA |
1860.9 | — |
Summary
Background:
* Essential tremor (ET) is a neurological disorder characterized by uncontrollable shaking. Several medications are used to treat ET; however, they are often only partly effective and can have side effects.
* Research studies have shown that octanol, a food additive similar to alcohol, can improve tremor in animals. Octanol is less likely to make people drunk than alcohol. Two earlier NIH studies found that one form of octanol, called 1-octanol, did improve tremor in some people and had few side effects.
* In the body, 1-octanol is converted to octanoic acid. Researchers are interested in finding out whether octanoic acid can help people with ET.
Objectives:
* To find out if octanoic acid can improve hand tremor in people with essential tremor.
* To measure levels of octanoic acid in the blood after it is taken.
Eligibility:
* Patients 21 years of age and older with ET, who are willing to abstain from alcohol, caffeine, and all medications as required by the study and who are willing and able to fast for up to 12 hours at a time.
* Participants may not be of Asian or Native American ancestry because of genetic susceptibilities to the intoxicating effects of the study drug.
Design:
* This study requires a 3-day hospital admission as well as two outpatient visits.
* Visit 1 (outpatient): Screening visit and blood alcohol level test
* Medical history, physical and neurological examination, a blood test, and an electrocardiogram to measure heart function. Women who are able to get pregnant will have a urine pregnancy test.
* Patients will consume 1.5 ounces of alcohol per drink (up to three drinks at least 30 minutes apart), and be tested to evaluate how the tremor responds. Researchers will draw blood to measure blood alcohol level about 1 hour after the first drink and closely monitor patients for signs of intoxication.
* Inpatient examination
* Preparation: Researchers will prepare a schedule to stop any tremor medications that patients might be on. Patients may not drink alcohol or eat or drink anything with caffeine, including chocolate, for at least 2 days before admission.
* Day 1: Vital signs, blood (and urine pregnancy) tests, and electrocardiogram. Patients will be asked to wear a tremor monitor, similar to a wristwatch. Patients will also have IV lines inserted for blood draws.
* Days 2 and 3: Randomized study medication (octanoic acid on one day, placebo on the other day). Patients will fast before taking the drug, but will be allowed to eat and drink after the tests are completed (around noon).
* Blood will be drawn before taking the study drug and again (a total of nine times) after taking the drug.
* Tremor will be measured during the study, before and after taking the drug.
* Visit 2 (outpatient): 4 to 7 days after discharge
* Blood test and an electrocardiogram, and a series of questionnaires regarding the study.
Eligibility Criteria
- INCLUSION CRITERIA:
- Male or female patients with alcohol-responsive ET according to published clinical criteria
- Tremor in both upper limbs should be predominant feature of ET
- Subjects must be willing and safely able to comply with the study protocol and therefore abstain from any medication for the treatment of tremor for a period of at least 5 plasma half-lives of the individual drug prior to study participation. (For Propranolol/Inderal(Registered Trademark), Gabapentin/Neurontin(Registered Trademark), Topiramate/Topamax(Registered Trademark) this will be 4 days; for Primidone/Mysoline(Registered Trademark): 28 days).
- Subjects must be willing to refrain from alcohol and caffeine intake starting 48 hr prior to hospitalization until study termination
- Subject must be willing and able to fast for periods of up to 12 hours during the study
EXCLUSION CRITERIA
- Patients with any other significant pathological finding in the neurological examination other than typical symptoms of ET
- Acute or chronic severe medical conditions which would preclude the subject from participating (e.g., severe heart disease NYHA grade 3 or 4, renal failure, hepatic failure, lung disease, uncontrolled hyperthyroidism)
- Subjects with diabetes mellitus, hypoglycemia or severe hyperlipidemia (must be documented by referring physician with copy of last fasting routine blood test within one year before the screening visit including glucose and lipid levels; according to NIH guidelines, fasting LDL levels of greater than or equal to 160 mg/dl are considered severe hyperlipidemia; if under treatment, LDL-levels less than 160 have to be documented to be eligible for the study)
- Subjects with active or past alcohol abuse or dependence
- Subjects with concomitant therapy with warfarin or NSAIDs, when taken on a regular basis and cannot be discontinued at least 14 days prior to study participation, because of potential interactions with octanoic acid (displacement of albumin binding in human serum)
- Subjects with clinically significant abnormalities on their baseline laboratory tests
- Subjects aged less than 21 years
- Female subjects who are pregnant or lactating
- Subjects with cognitive impairment interfering with the ability to give informed consent or to cooperate during the study
- Subjects of Far East Asian or Native American descent, who may possess variant alleles of the genes for alcohol metabolism, i.e., alcohol dehydrogenase and aldehyde dehydrogenase, resulting in altered (slower) metabolism and potentially increased sensitivity to alcohols and their metabolites
- Subjects where no written informed consent is received or subjects who are unwilling to cooperate during the study
Data sourced from ClinicalTrials.gov (NCT00848172). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.