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Home › Conditions › Essential Tremor

Essential Tremor

Part of Movement Disorders

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Essential Tremor

31 trials tracked for Essential Tremor: 4 in phase 3 or 4.

31Trials tracked
4Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 3 Phase 3 1 Phase 2 12 Phase 1 1 Other / NA 14
  1. Phase 4 Propranolol and Botulinum Toxin for Essential Vocal Tremor Completed
  2. Phase 4 Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response Completed
  3. Phase 4 RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR) Completed
  4. Phase 3 A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Completed
  5. Phase 2 Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor Completed
  6. Phase 2 A Study to Evaluate SAGE-217 in Participants With Essential Tremor Completed
Show 25 more trials
  1. Phase 2 Study to Evaluate SAGE-324 in Participants With Essential Tremor Completed
  2. Phase 2 A Clinical Study to Evaluate CAD-1883 in Essential Tremor Completed
  3. Phase 2 A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Completed
  4. Phase 2 A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Completed
  5. Phase 2 Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor Completed
  6. Phase 2 A Clinical Trial of PRAX-944 in Participants With Essential Tremor Completed
  7. Phase 2 Evaluate SAGE-547 in Participants With Essential Tremor Completed
  8. Phase 2 A Phase 2 RCT Study of CX-8998 for Essential Tremor Completed
  9. Phase 2 Trial of Cannabis for Essential Tremor Completed
  10. Phase 2 Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor Completed
  11. Phase 1 Pregabalin in the Treatment of Essential Tremor Completed
  12. N/A Prospective Study for Symptomatic Relief of ET With Cala Therapy Completed
  13. N/A A Pilot Study to Assess the Effects of Pre-SMA LF-rTMS for the Treatment of Essential Tremor Completed
  14. N/A Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Completed
  15. N/A Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET) Completed
  16. N/A A Pilot Study of the Cala ONE Device for Essential Tremor Completed
  17. N/A A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling Completed
  18. N/A Wearable Sensor for Responsive DBS for ET Completed
  19. N/A Compare Rates of Agreement Between Clinical Diagnosis and Visual Assessment of DaTscan™ Images in Non-Caucasian and Caucasian Subjects With Parkinson's Disease (PD) or Essential Tremor (ET) Completed
  20. N/A Deep Brain Stimulation (DBS) for the Suppression of Tremor Completed
  21. N/A Essential Voice Tremor: A Study of Botulinum Toxin Treatment and Injection Augmentation Completed
  22. N/A Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Completed
  23. N/A Cala ONE Device for Essential Tremor Completed
  24. N/A Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Completed
  25. N/A ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Essential Tremor: what the trials found

Established evidence for essential tremor management includes the use of Transcranial ExAblate, which demonstrated significant improvements in motor scores. Specifically, one trial showed a statistically significant reduction in the Clinical Rating Scale for Tremor (CRST) Part A and B compared to placebo (p<0.001), with notable percentage improvements across multiple sub-measures 21. Another study confirmed that Transcranial ExAblate resulted in lower tremor motor scores and improved posture scores compared to baseline 20.

Pharmacological management includes Propranolol, which has been evaluated in clinical settings for essential tremor [1, 2]. Additionally, SAGE-324 showed a statistically significant improvement in the TETRAS Performance Subscale Part 4 Upper Limb Tremor Score on Day 29 compared to placebo (p=0.0491) and across multiple subsequent time points (p=0.0468) 7.

Diagnostic and monitoring tools such as DaTSCAN™ Ioflupane (123I) Injection have been utilized in clinical trials for related conditions 4, while the Activa RC system was evaluated for hardware reliability with no reported issues in early stages 3.

Recent results — preliminary, needs further review

  • Ultrasound Imaging showed a 62.4% tremor suppression rate 18.

For the clinician treating this condition

  • Transcranial ExAblate is supported by evidence showing significant reductions in tremor motor scores and improved postural stability.
  • SAGE-324 demonstrated statistically significant improvements in upper limb tremor scores on the TETRAS scale compared to placebo.
  • Propranolol remains an established intervention for managing essential tremor symptoms.

AI synthesis of 6 cited trials, updated Jun 22, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Botulinum toxin type A reduces upper-limb tremor severity in patients with essential tremor
Neurology Meta-analysis
Botulinum toxin type A reduces upper-limb tremor severity in patients with essential tremor Botulinum Toxin Type A Reduces Tremor in Upper Limbs
This meta-analysis of 231 patients with upper-limb essential tremor found that botulinum toxin type A significantly reduced clinician-rated …
Botulinum toxin type A can reduce tremor severity in adults with essential tremor, though it may also lead to some muscle weakness.
Frontiers Aug 28, 2026
Propranolol shows potential for managing various neurological diseases including PTSD, migraine, and autism spectrum disorder
Psychiatry Sys. Review
Propranolol shows potential for managing various neurological diseases including PTSD, migraine, and autism spectrum disorder Propranolol Shows Promise for Brain Conditions
This systematic review synthesizes clinical and preclinical evidence regarding the effects of propranolol on several neurological conditions…
A new review suggests propranolol, a common blood pressure drug, may help with PTSD, autism, and more. Here's what it means.
Frontiers Aug 17, 2026
Peripheral nerve stimulation significantly reduces tremor intensity and functional disability in essential tremor
Anesthesiology & Pain Medicine Meta-analysis
Peripheral nerve stimulation significantly reduces tremor intensity and functional disability in essential tremor Nerve stimulation reduces essential tremor in short term
This meta-analysis of 914 patients with essential tremor found that peripheral nerve stimulation (PNS) resulted in a statistically significa…
A new analysis finds that peripheral nerve stimulation can safely reduce tremor and improve daily function in people with essential tremor.
Jul 24, 2026
Vim-targeted tremor surgery shows substantial tremor improvement across various targeting approaches
Nephrology Meta-analysis
Vim-targeted tremor surgery shows substantial tremor improvement across various targeting approaches Deep brain stimulation for tremor shows consistent improvement across different targeting methods
A systematic review and meta-analysis of 211 patients undergoing Vim-targeted tremor surgery found substantial tremor improvement across ana…
Surgery targeting a specific brain area consistently reduces severe tremor regardless of the surgical guidance method used, offering reliabl…
medRxiv Apr 9, 2026
Staged bilateral MRgFUS thalamotomy associated with tremor reduction in medication-refractory essential tremor
Radiology & Imaging Meta-analysis
Staged bilateral MRgFUS thalamotomy associated with tremor reduction in medication-refractory essential tremor Second ultrasound brain procedure shows tremor improvement in small study
A meta-analysis and prospective single-center observational cohort of 15 patients undergoing second-side MRgFUS thalamotomy for medication-r…
A second ultrasound brain procedure improved hand tremor by 58% and daily life impact by 69% in people with essential tremor, though some ve…
Apr 6, 2026
Staged bilateral MRgFUS thalamotomy for essential tremor shows consistent procedural parameters in small cohort
Radiology & Imaging Meta-analysis
Staged bilateral MRgFUS thalamotomy for essential tremor shows consistent procedural parameters in small cohort Study examines brain lesion patterns in patients receiving two ultrasound tremor treatments
A single-centre observational study of 15 patients with essential tremor undergoing staged bilateral MRgFUS thalamotomy found procedural and…
A second focused ultrasound treatment for tremor targets a slightly different brain spot than the first, with most side effects being mild a…
Frontiers Apr 6, 2026
Retrospective study finds 12.1% of PD/ET patients underwent DBS surgery at a tertiary center
Neurology Cohort
Retrospective study finds 12.1% of PD/ET patients underwent DBS surgery at a tertiary center Who gets brain surgery for Parkinson's? Insurance and neighborhood matter
A retrospective cohort study of 3286 PD/ET patients at a single tertiary center found 12.1% underwent DBS surgery.
At one major center, patients with public insurance and low-income neighborhoods were more likely to get advanced brain surgery for Parkinso…
Frontiers Apr 4, 2026

Questions about Essential Tremor

Can Vim-targeted surgery improve Essential Tremor for different targeting approaches?

Vim-targeted surgery improves essential tremor regardless of the targeting method used, with options ranging from atlas-based coordinates to microelectrode recording and advanced MRI techniques.

Full answer →