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Home › Conditions › Essential Tremor

Essential Tremor

Part of Movement Disorders

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Essential Tremor

31 trials tracked for Essential Tremor: 4 in phase 3 or 4.

31Trials tracked
4Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 3 Phase 3 1 Phase 2 12 Phase 1 1 Other / NA 14
  1. Phase 4 Propranolol and Botulinum Toxin for Essential Vocal Tremor Completed
  2. Phase 4 Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response Completed
  3. Phase 4 RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR) Completed
  4. Phase 3 A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Completed
  5. Phase 2 Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor Completed
  6. Phase 2 A Study to Evaluate SAGE-217 in Participants With Essential Tremor Completed
Show 25 more trials
  1. Phase 2 Study to Evaluate SAGE-324 in Participants With Essential Tremor Completed
  2. Phase 2 A Clinical Study to Evaluate CAD-1883 in Essential Tremor Completed
  3. Phase 2 A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Completed
  4. Phase 2 A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Completed
  5. Phase 2 Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor Completed
  6. Phase 2 A Clinical Trial of PRAX-944 in Participants With Essential Tremor Completed
  7. Phase 2 Evaluate SAGE-547 in Participants With Essential Tremor Completed
  8. Phase 2 A Phase 2 RCT Study of CX-8998 for Essential Tremor Completed
  9. Phase 2 Trial of Cannabis for Essential Tremor Completed
  10. Phase 2 Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor Completed
  11. Phase 1 Pregabalin in the Treatment of Essential Tremor Completed
  12. N/A Prospective Study for Symptomatic Relief of ET With Cala Therapy Completed
  13. N/A A Pilot Study to Assess the Effects of Pre-SMA LF-rTMS for the Treatment of Essential Tremor Completed
  14. N/A Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Completed
  15. N/A Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET) Completed
  16. N/A A Pilot Study of the Cala ONE Device for Essential Tremor Completed
  17. N/A A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling Completed
  18. N/A Wearable Sensor for Responsive DBS for ET Completed
  19. N/A Compare Rates of Agreement Between Clinical Diagnosis and Visual Assessment of DaTscan™ Images in Non-Caucasian and Caucasian Subjects With Parkinson's Disease (PD) or Essential Tremor (ET) Completed
  20. N/A Deep Brain Stimulation (DBS) for the Suppression of Tremor Completed
  21. N/A Essential Voice Tremor: A Study of Botulinum Toxin Treatment and Injection Augmentation Completed
  22. N/A Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Completed
  23. N/A Cala ONE Device for Essential Tremor Completed
  24. N/A Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Completed
  25. N/A ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Vim-targeted tremor surgery shows substantial tremor improvement across various targeting approaches
Nephrology Meta-analysis
Vim-targeted tremor surgery shows substantial tremor improvement across various targeting approaches Deep brain stimulation for tremor shows consistent improvement across different targeting methods
A systematic review and meta-analysis of 211 patients undergoing Vim-targeted tremor surgery found substantial tremor improvement across ana…
Surgery targeting a specific brain area consistently reduces severe tremor regardless of the surgical guidance method used, offering reliabl…
medRxiv Apr 9, 2026
Staged bilateral MRgFUS thalamotomy associated with tremor reduction in medication-refractory essential tremor
Radiology & Imaging Meta-analysis
Staged bilateral MRgFUS thalamotomy associated with tremor reduction in medication-refractory essential tremor Second ultrasound brain procedure shows tremor improvement in small study
A meta-analysis and prospective single-center observational cohort of 15 patients undergoing second-side MRgFUS thalamotomy for medication-r…
A second ultrasound brain procedure improved hand tremor by 58% and daily life impact by 69% in people with essential tremor, though some ve…
Apr 6, 2026
Staged bilateral MRgFUS thalamotomy for essential tremor shows consistent procedural parameters in small cohort
Radiology & Imaging Meta-analysis
Staged bilateral MRgFUS thalamotomy for essential tremor shows consistent procedural parameters in small cohort Study examines brain lesion patterns in patients receiving two ultrasound tremor treatments
A single-centre observational study of 15 patients with essential tremor undergoing staged bilateral MRgFUS thalamotomy found procedural and…
A second focused ultrasound treatment for tremor targets a slightly different brain spot than the first, with most side effects being mild a…
Frontiers Apr 6, 2026
Retrospective study finds 12.1% of PD/ET patients underwent DBS surgery at a tertiary center
Neurology Cohort
Retrospective study finds 12.1% of PD/ET patients underwent DBS surgery at a tertiary center Who gets brain surgery for Parkinson's? Insurance and neighborhood matter
A retrospective cohort study of 3286 PD/ET patients at a single tertiary center found 12.1% underwent DBS surgery.
At one major center, patients with public insurance and low-income neighborhoods were more likely to get advanced brain surgery for Parkinso…
Frontiers Apr 4, 2026

Questions about Essential Tremor

Can Vim-targeted surgery improve Essential Tremor for different targeting approaches?

Vim-targeted surgery improves essential tremor regardless of the targeting method used, with options ranging from atlas-based coordinates to microelectrode recording and advanced MRI techniques.

Full answer →