N/A N=86 Randomized

Sedation and Pain (The Effect of IV Sedation on Pain Perception)

Pain

Bottom Line

View on ClinicalTrials.gov: NCT00853333 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2014

Primary outcome: Primary: Pain Rating Change — -0.253; 0.762; -0.346 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: dexmedetomidine (Drug); midazolam (Drug); propofol (Drug)
Age: Adult · 19+ yrs
Sex: All
Sponsor: University of Alabama at Birmingham
Primary completion: Jan 2012

Outcome Measures

Outcome	Result	p-value
PRIMARY Pain Rating Change	-0.253; 0.762; -0.346	—

Summary

The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).

Eligibility Criteria

Inclusion Criteria

Healthy subjects

19 years or older able to follow study instructions

Exclusion Criteria

Age less than 19 or greater than 40
Pregnant female
Obesity (BMI > or =35)
Non-English speaking/reading participants
Sleep apnea
Pulmonary problems such as moderate or severe bronchial asthma
Cardiovascular problems such as hypertension
History of claustrophobia
Presence of a pacemaker, defibrillator, surgically placed metallic object (e.g., hip replacement)or other implanted device
Presence of an unremoved bullet or shrapnel in the body
Presence of a prosthetic that is not removable
Presence of a hearing aid needed for hearing
Head girth exceeding that of the head coil used in the magnet
Extensive metalwork on or in teeth, or irremovable false teeth or bridgework
Epilepsy
Chronic analgesic medication
Excessive tattoos (due to local skin heating with tattoos containing ferromagnetic particles)
History of surgery for which details are unavailable
Allery due to study drugs
History of drug abuse

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00853333). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.