N/A
Completed N=50
Myocardial Stress Perfusion Imaging With Dual Source CT
Source: ClinicalTrials.gov NCT00853671 ↗Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Dec 2018
Primary outcomePrimary: Per-Vessel Sensitivity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography. — 79 percentage of participants
Summary
The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan. The investigators hypothesize that a coronary CTA protocol can be devised to obtain resting myocardial perfusion, myocardial perfusion after stress, and coronary anatomy. Hence, one diagnostic test will be able to detect the presence of coronary plaque as well as assess the functional significance of a stenosis.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Per-Vessel Sensitivity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography. |
79 | — |
| PRIMARY Per-Vessel Specificity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography. |
80 | — |
| SECONDARY Per-Patient Correlation Between CTP and SPECT at Stress. |
0.60 | <0.0001 sig |
| SECONDARY Per-Patient Correlation Between CTP and SPECT at Rest. |
0.76 | <0.0001 sig |
Eligibility Criteria
Inclusion Criteria
- A prior adenosine or exercise stress SPECT exam with high likelihood of being referred to the cardiac catheterization laboratory for invasive angiogram
- Age > 40 years old
- Able to comprehend and sign the consent form.
Exclusion Criteria
- Acute coronary syndromes (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction)
- Unstable clinical conditions (i.e. hemodynamic instability, arrhythmias)
- Premenopausal women who have a positive pregnancy test.
- Serum Creatinine level ≥1.5 mg/dl as an indicator of renal insufficiency.
- Known allergy to iodinated contrast agents
- Atrial fibrillation
- Asthma
- Critical aortic stenosis
- Systolic blood pressure < 90 mmHg
- Advanced heart block
Data sourced from ClinicalTrials.gov (NCT00853671). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.