Phase 4
Completed N=12
Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibition on Hormonal Responses to Macronutrient Ingestion
Healthy · Type 2 Diabetes
Source: ClinicalTrials.gov NCT00885638 ↗
Enrolled (actual)
12
Serious AEs
0.0%
Results posted
Jan 2013
Primary outcomePrimary: Glucagon-like Peptide-1 Secretion After Meal Ingestion — 0.82; 1.24 nmol/l/min
Summary
The regulation by DPP-4 inhibition after ingested of different individual macronutrients is not known. Therefore, this study examines the influence of ingestion of fat, protein, glucose or mixed meal on the concentrations of incretin hormones and insulin secretion with or without concomitant administration of a DPP-4 inhibitor (sitagliptin).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Glucagon-like Peptide-1 Secretion After Meal Ingestion |
0.82; 1.24 | — |
| SECONDARY Insulin Secretion After Ingestion of Meal |
29.6; 24.7 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy men
- Age 20-30 years
- BMI 20-30 kg/m2
Exclusion Criteria
- Any disease
- Any medication
Data sourced from ClinicalTrials.gov (NCT00885638). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.