Phase 4
Completed N=50
Optimizing Local Anesthetic Concentration for Continuous Lumbar Plexus Nerve Blocks
Source: ClinicalTrials.gov NCT00912873 ↗Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Mar 2021
Primary outcomePrimary: Percent Change From Baseline in Quadriceps Femoris Maximum Voluntary Isometric Contraction (MVIC) — 64.1; 68 percentage change from baseline of MVIC
◆ Published Evidence
Established
97citations · ~6 / year
Continuous peripheral nerve blocks: is local anesthetic dose the only factor, or do concentration and volume influence infusion effects as well?
Summary
This is a research study to determine if the concentration of local anesthetic through a catheter next to the nerves that go to the hip that is undergoing surgery, affects muscle strength and sense of touch experienced after surgery. This study is looking at the varying concentrations of local anesthetic placed through the catheter.
Linked Publications
-
Continuous peripheral nerve blocks: is local anesthetic dose the only factor, or do concentration and volume influence infusion effects as well?
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent Change From Baseline in Quadriceps Femoris Maximum Voluntary Isometric Contraction (MVIC) |
64.1; 68 | — |
| SECONDARY Ambulation 100-foot Walking Test |
4.6; 5.3; 4.0; 3.6 | — |
| SECONDARY Total Ambulation |
136; 119; 223; 214 | — |
| SECONDARY Percent Change From Baseline in Hip Flexion |
69; 67; 75; 78 | — |
| SECONDARY Mean Resting Pain |
3.2; 3.2 | — |
| SECONDARY Average Dynamic Pain |
3.8; 3.8; 3.2; 2.9 | — |
| SECONDARY Worst Dynamic Pain |
6.2; 6.5; 4.3; 5.0 | — |
Eligibility Criteria
Inclusion Criteria
- Primary, unilateral hip arthroplasty
- age greater than or equal to 18 years
- postoperative analgesic plan includes perineural local anesthetic infusion
Exclusion Criteria
- morbid obesity as defined by a body mass index greater than 40
- chronic high dose opioid use
- history of opioid abuse
- neuro-muscular deficit of the ipsilateral femoral nerve and/or quadriceps muscle
- vulnerable populations i.e., children, pregnant women, or prisoners
Data sourced from ClinicalTrials.gov (NCT00912873) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.