N/A
N=60
Neurophysiological Targets for Cognitive Training in Schizophrenia
Schizophrenia
Bottom Line
View on ClinicalTrials.gov: NCT00923078 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Dec 2017
Primary outcome: Primary: Visual Target Detection (P300 Event-related Potential Amplitude) Change — 2.20; -0.72 microvolts (uV) — p=<0.05
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Auditory Cognitive Training (Behavioral); Visual Cognitive Training (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Oct 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Visual Target Detection (P300 Event-related Potential Amplitude) Change |
2.20; -0.72 | <0.05 sig |
| PRIMARY Auditory Mismatch Negativity (MMN) Amplitude Change |
0.67; 0.51 | <0.05 sig |
| PRIMARY MCCB Cognitive Composite Score Change |
-2.03; -2.45 | <0.01 sig |
| SECONDARY Visual Learning (BVMT-R) Change |
-2.92; -3.24 | 0.06 |
| SECONDARY Verbal Learning (HVLT-R) Change |
0.62; 0.03 | 0.55 |
| SECONDARY Visual Working Memory (Spatial Span) Change |
-0.60; -0.92 | 0.63 |
| SECONDARY Auditory Working Memory (LNS) Change |
-1.10; -1.47 | 0.26 |
Summary
The purpose of this study is to determine whether computer-based training of auditory and visual processing results in corresponding improvement in brain function in individuals with schizophrenia.
Eligibility Criteria
Inclusion Criteria
- DSM-IV diagnosis of schizophrenia or schizoaffective disorder
- Age between 18 & 70
- minimum of 30 days since discharge from last hospitalization
- minimum of 30 days since last change in psychiatric medications
- receiving mental health services
- no housing changes in the past 30 days
Exclusion Criteria
- current diagnosis of alcohol or substance abuse
- history of brain trauma or neurological disease
- chart diagnosis of mental retardation or premorbid intelligence < 70 based on Wechsler Test of Adult Reading (WTAR) full-scale estimated IQ
- auditory or visual impairment that would interfere with study procedures
- a sample of 20 healthy community volunteers was also recruited according to these criteria and tested, without intervention, as a normative reference sample for MMN and P300 measures
Data sourced from ClinicalTrials.gov (NCT00923078). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.