Phase 2 N=30 Randomized Treatment

Sodium Nitrite in Acute Myocardial Infarction

Acute Myocardial Infarction

Bottom Line

View on ClinicalTrials.gov: NCT00924118 ↗

Enrolled (actual)

Serious AEs

13.3%

Results posted

Sep 2017

Primary outcome: Primary: Ischemia Area at Risk as Determined by Paired Single-photon Computed Tomography Studies With Technetium Tc99m Sestamibi.

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: Sodium Nitrite (Drug)
Age: Adult, Older Adult · 21+ yrs
Sex: All
Sponsor: Johns Hopkins University
Primary completion: Jun 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Ischemia Area at Risk as Determined by Paired Single-photon Computed Tomography Studies With Technetium Tc99m Sestamibi.	—	—
SECONDARY Left Ventricular Infarct Size	15.5; 24	—

Summary

The purpose of this study is to determine whether the intravenous infusion of sodium nitrite safely prevents ischemia-reperfusion injury in subjects with acute myocardial infarction resulting in improved left ventricular function.

Eligibility Criteria

Inclusion Criteria

Acute ST segment elevation myocardial infarction
Eligible for percutaneous coronary intervention

Exclusion Criteria

Cardiogenic shock
Cardiac arrest
Prior infarct in the infarct related artery
Hemoglobinopathy, Glucose-6 Phosphate Dehydrogenase (G6PD) deficiency

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00924118). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.