N/A
Completed N=12
Exercise Program in Women With Metabolic Syndrome
Source: ClinicalTrials.gov NCT00929500 ↗Enrolled (actual)
12
Serious AEs
8.3%
Results posted
Sep 2017
Primary outcomePrimary: Maximal Oxygen Uptake — 18.3; 15.8; 18.6; 14.4 ml/kg/min
Summary
The purpose of this study is to test whether a supervised mixed aerobic and strength training (MAST) program is effective in improving overall physical fitness and blood flow in the brain and lowering risk factors of coronary artery disease (CAD) in women with metabolic syndrome.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maximal Oxygen Uptake |
18.3; 15.8; 18.6; 14.4 | — |
| SECONDARY Cerebral Blood Flow Velocity (BFV) |
37.4; 41.7; 34.7; 33.9; 33.3; 36.7 | — |
| SECONDARY Trail Making Test |
29.1; 31.2; 78.4; 64.9; 49.3; 33.7 | — |
| SECONDARY Muscle Strength |
96.7; 95; 103.3; 90 | — |
Eligibility Criteria
Inclusion Criteria
- Post-menopausal women
- Age 50 or over
- Diagnosed metabolic syndrome
Exclusion Criteria
- Any unstable or acute medical condition that the study physician deem unsafe for participation
- Positive stress test for CAD or other ischemic conditions
- Myocardial infarction or major surgery within 6 months
- History of a clinically documented stroke
- Clinical dementia (by history) or inability to follow details of the protocol
- Carotid stenosis > 50% by medical history
- Insulin dependent diabetes mellitus (also type II, if using insulin) or history of severe hypoglycemic episodes within 6 months requiring hospitalization
- Liver or renal failure or transplant
- Severe blood pressure elevation (systolic BP > 180 and/or diastolic BP > 110 mm Hg)
- Anemia (Hb 45, but body weight under 280 lbs
- Inability to obtain permission for participation from the primary care physician
- Clinically significant and movement limiting hip, knee and/or back disorders or injury, and rheumatoid arthritis
- Transcranial Doppler (TCD) exclusion criteria - poor insonation window and TCD signal
Data sourced from ClinicalTrials.gov (NCT00929500). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.