N/A N=12 Randomized Single-blind Other

Exercise Program in Women With Metabolic Syndrome

Metabolic Syndrome

Bottom Line

View on ClinicalTrials.gov: NCT00929500 ↗

Enrolled (actual)

Serious AEs

8.3%

Results posted

Sep 2017

Primary outcome: Primary: Maximal Oxygen Uptake — 18.3; 15.8; 18.6; 14.4 ml/kg/min

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: MAST program (Behavioral)
Age: Adult, Older Adult · 50+ yrs
Sex: Female
Sponsor: Beth Israel Deaconess Medical Center
Primary completion: May 2010

Outcome Measures

Outcome	Result	p-value
PRIMARY Maximal Oxygen Uptake	18.3; 15.8; 18.6; 14.4	—
SECONDARY Cerebral Blood Flow Velocity (BFV)	37.4; 41.7; 34.7; 33.9; 33.3; 36.7	—
SECONDARY Trail Making Test	29.1; 31.2; 78.4; 64.9; 49.3; 33.7	—
SECONDARY Muscle Strength	96.7; 95; 103.3; 90	—

Summary

The purpose of this study is to test whether a supervised mixed aerobic and strength training (MAST) program is effective in improving overall physical fitness and blood flow in the brain and lowering risk factors of coronary artery disease (CAD) in women with metabolic syndrome.

Eligibility Criteria

Inclusion Criteria

Post-menopausal women
Age 50 or over
Diagnosed metabolic syndrome

Exclusion Criteria

Any unstable or acute medical condition that the study physician deem unsafe for participation
Positive stress test for CAD or other ischemic conditions
Myocardial infarction or major surgery within 6 months
History of a clinically documented stroke
Clinical dementia (by history) or inability to follow details of the protocol
Carotid stenosis > 50% by medical history
Insulin dependent diabetes mellitus (also type II, if using insulin) or history of severe hypoglycemic episodes within 6 months requiring hospitalization
Liver or renal failure or transplant
Severe blood pressure elevation (systolic BP > 180 and/or diastolic BP > 110 mm Hg)
Anemia (Hb 45, but body weight under 280 lbs
Inability to obtain permission for participation from the primary care physician
Clinically significant and movement limiting hip, knee and/or back disorders or injury, and rheumatoid arthritis
Transcranial Doppler (TCD) exclusion criteria - poor insonation window and TCD signal

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00929500). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.