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Home › Conditions › Metabolic Syndrome

Metabolic Syndrome

Part of Insulin Resistance

45 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Metabolic Syndrome

132 trials tracked for Metabolic Syndrome: 28 in phase 3 or 4 and 8 with published results. The most-cited published study has 43 citations.

132Trials tracked
28Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 18 Phase 3 10 Phase 2 31 Phase 1 4 Other / NA 69
  1. Phase 3 Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies. Completed · 43 cited
  2. Phase 4 Niacin, N-3 Fatty Acids and Insulin Resistance Completed · 42 cited
  3. Phase 3 Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM) Completed · 40 cited
  4. Phase 3 Exercise Dose and Metformin for Vascular Health in Metabolic Syndrome Completed · 32 cited
  5. Phase 3 A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both Completed · 16 cited
  6. Phase 3 The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome Completed · 12 cited
Show 44 more trials
  1. Phase 4 Effect on Liver Fat and Metabolic Parameters When Switching a Protease Inhibitor or Efavirenz to Raltegravir Completed · 9 cited
  2. Phase 3 A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes Completed · 3 cited
  3. Phase 4 Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle. Completed
  4. Phase 4 Endogenous Opioid Activity and Affective State in Insulin Resistant Women Completed
  5. Phase 4 Impact of Ranolazine in Blood Markers in Women With Angina and Metabolic Syndrome Completed
  6. Phase 4 Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism Completed
  7. Phase 4 Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 a Subfraction of LDL in Patients With Metabolic Syndrome. Completed
  8. Phase 4 Comparison of Secukinumab 300 mg Combined With a Lifestyle Intervention to Secukinumab Alone for the Treatment of Moderate to Severe Psoriasis Patients With Concomitant Metabolic Syndrome Completed
  9. Phase 4 Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment Completed
  10. Phase 4 The Effect of Fluvastatin XL® Treatment in Patients With Metabolic Syndrome Completed
  11. Phase 4 Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance Completed
  12. Phase 4 Effect of Aged Garlic Extract on Atherosclerosis Completed
  13. Phase 4 Comparative Effect of Nebivolol vs. Metoprolol on Insulin Sensitivity and Fibrinolytic Balance in Metabolic Syndrome Completed
  14. Phase 4 Mechanisms Underlying Metabolic Syndrome in Obesity Completed
  15. Phase 4 Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome Completed
  16. Phase 4 The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study Completed
  17. Phase 4 Effect of Crestor (Rosuvastatin) on Lipid Levels in Patients With Metabolic Syndrome Completed
  18. Phase 4 Study of Vardenafil in Patients Suffering From Erectile Dysfunction and Metabolic Syndrome Completed
  19. Phase 3 A Study of Two Doses of Dulaglutide (LY2189265) in Japanese Patients With Type 2 Diabetes Completed
  20. Phase 3 An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia Completed
  21. Phase 3 Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia Completed
  22. Phase 3 Ezetimibe/Simvastatin in Patients With Metabolic Syndrome (0653A-107)(COMPLETED) Completed
  23. Phase 2 Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults Completed
  24. Phase 2 Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency Completed
  25. Phase 2 Oral Nitrite in Adults With Metabolic Syndrome and Hypertension Completed
  26. Phase 2 Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome Completed
  27. Phase 2 Prothrombotic Inflammatory Markers in Women With Metabolic Syndrome - Effect of Atorvastatin Completed
  28. Phase 2 Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic Syndrome Completed
  29. Phase 2 Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetes Completed
  30. Phase 2 Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases Completed
  31. Phase 2 Effect of Fucoxanthin on the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion Completed
  32. Phase 2 Metformin in Kidney Disease Completed
  33. Phase 2 Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome Completed
  34. Phase 2 Evaluation of 3-V Bioscience-2640 to Reduce de Novo Lipogenesis in Subjects With Characteristics of Metabolic Syndrome Completed
  35. Phase 2 Effects of Leptin Replacement in Children Completed
  36. Phase 2 Pioglitazone vs Placebo in Combination With Niacin Extended Release on Low HDL Completed
  37. Phase 2 Safety and Efficacy Study of ISIS 301012 (Mipomersen) Administration in High Risk Statin Intolerant Subjects Completed
  38. Phase 2 A Study of LY3561774 in Participants With Mixed Dyslipidemia Completed
  39. Phase 2 Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes Completed
  40. Phase 2 T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin Completed
  41. Phase 2 Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration Completed
  42. Phase 2 Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction Completed
  43. Phase 2 Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia Completed
  44. Phase 2 Islet Allotransplantation With Steroid Free Immunosuppression Completed

Showing the 50 most-cited and recently-updated of 132 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ultra-processed food consumption is associated with metabolic syndrome, cardiovascular risk, and allergic diseases in children
Nutrition & Obesity Medicine Sys. Review
Ultra-processed food consumption is associated with metabolic syndrome, cardiovascular risk, and allergic diseases in children Ultra-processed foods linked to childhood weight and heart risks
This narrative review synthesizes evidence regarding the impact of ultra-processed food (UPF) on pediatric health. High UPF intake is linked…
High intake of ultra-processed foods is linked to weight gain, metabolic issues, and higher rates of asthma and skin conditions in children.
Frontiers Jun 12, 2026
Early-life microbiome shapes allergic, metabolic, and respiratory disease risk
Infectious Disease Sys. Review
Early-life microbiome shapes allergic, metabolic, and respiratory disease risk Gut and Lung Microbiome in Early Life Linked to Health
This narrative review synthesizes evidence on how the human gut and lung microbiome in early life influences allergic diseases, metabolic di…
A review suggests the gut and lung microbiome in early life may influence allergies, metabolism, and respiratory health.
Frontiers Jun 7, 2026
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
Nutrition & Obesity Medicine Meta-analysis
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults Pre-existing health conditions may slightly reduce weight loss after surgery
A meta-analysis of twenty-three studies reveals that mental illness, diabetes, and sleep apnea are associated with slightly lower weight los…
Adults with mental illness or diabetes before surgery saw slightly less weight loss. Other conditions like high blood pressure did not affec…
Jun 6, 2026
Bile acid modifications and microbiota interventions show promise for metabolic and digestive diseases in preclinical models
Diabetes & Endocrinology Sys. Review
Bile acid modifications and microbiota interventions show promise for metabolic and digestive diseases in preclinical models Bile acid and microbiota changes may help treat several diseases
This narrative review examines bile acid modifications, microbiota interventions, and BA-targeted therapies for metabolic, digestive, hepato…
This review explores how changing bile acids and gut bacteria could treat metabolic, digestive, and liver diseases, but most evidence is fro…
Frontiers Jun 4, 2026
Mediterranean diet triples metabolic syndrome reversal rate vs low-fat diet in interim trial
Nutrition & Obesity Medicine RCT
Mediterranean diet triples metabolic syndrome reversal rate vs low-fat diet in interim trial Mediterranean diet reverses metabolic syndrome in 36% of patients
This interim RCT in 246 Chilean adults with metabolic syndrome found that a Mediterranean diet (with or without psychological support) led t…
A Mediterranean diet reversed metabolic syndrome in 36% of patients, compared to 11% on a low-fat diet. Early results from a Chilean trial.
Jun 1, 2026
Metabolic syndrome linked to higher risk of several obesity-related cancers and worse colorectal cancer survival
Oncology Meta-analysis
Metabolic syndrome linked to higher risk of several obesity-related cancers and worse colorectal cancer survival Metabolic Syndrome Raises Cancer Risk And Worsens Survival For Some Patients
An umbrella review of 21 systematic reviews with meta-analyses found suggestive evidence that metabolic syndrome increases the risk of sever…
A big review found that metabolic syndrome makes obesity-related cancers more likely and can hurt survival chances. Doctors say fixing this …
Jun 1, 2026
General obesity, central obesity, and high triglycerides increase risk of precancerous polyps in colorectal cancer surveillance
Gastroenterology Meta-analysis
General obesity, central obesity, and high triglycerides increase risk of precancerous polyps in colorectal cancer surveillance Metabolic health matters for colon cancer risk in high-risk surveillance patients
This meta-analysis of 24 observational studies found that metabolic factors such as general obesity, central obesity, hypertension, and high…
Metabolic issues like obesity and diabetes raise the risk of precancerous polyps in people at higher risk for colon cancer. This analysis of…
Jun 1, 2026
Narrative review links hidradenitis suppurativa to metabolic dysfunction and systemic inflammation
Gastroenterology Sys. Review
Narrative review links hidradenitis suppurativa to metabolic dysfunction and systemic inflammation New review links skin disease to metabolic health in Hidradenitis suppurativa
This narrative review examines the association between hidradenitis suppurativa and metabolic syndrome. The authors argue that increasing ev…
A new review suggests Hidradenitis suppurativa is part of a broader inflammatory state tied to metabolic dysfunction, urging a multidiscipli…
Frontiers May 26, 2026
Narrative review of palmitoleic acid links to metabolic health and fatty liver outcomes
Nutrition & Obesity Medicine Sys. Review
Narrative review of palmitoleic acid links to metabolic health and fatty liver outcomes Palmitoleic Acid Shows Mixed Links to Metabolic Health
This narrative review examines palmitoleic acid (POA) supplementation and food matrices regarding insulin resistance, fatty liver, and hyper…
Higher palmitoleic acid levels are tied to fatty liver and insulin resistance, but supplements show neutral effects.
Frontiers May 26, 2026
Review links metabolic syndrome to 1.5 to 2 times higher atrial fibrillation risk
Cardiology Sys. Review
Review links metabolic syndrome to 1.5 to 2 times higher atrial fibrillation risk Metabolic syndrome raises atrial fibrillation risk by 1.5 to 2 times
This narrative review examines the association between metabolic syndrome and atrial fibrillation. The authors synthesize evidence suggestin…
Metabolic syndrome increases the risk of developing atrial fibrillation by 1.5 to 2 times, a finding that could help doctors target preventi…
Frontiers May 23, 2026
Narrative review examines metabolic syndrome and novel agents in kidney transplant recipients
Allergy & Immunology Sys. Review
Narrative review examines metabolic syndrome and novel agents in kidney transplant recipients Kidney transplant patients face high metabolic risks and rejection
This narrative review addresses antibody-mediated rejection and metabolic syndrome in kidney transplantation recipients. The authors note th…
About half of kidney transplant recipients develop metabolic problems within a year, while antibody-mediated rejection remains a major cause…
Frontiers May 21, 2026
Narrative review explores bromelain's potential across multiple chronic diseases
Psychiatry Sys. Review
Narrative review explores bromelain's potential across multiple chronic diseases Bromelain shows promise for several diseases but needs more human testing
This narrative review examines bromelain's potential in cancer, cardiovascular, metabolic, infectious, and neurodegenerative diseases. Most …
Bromelain looks promising for managing cancer and other conditions, yet current evidence mostly comes from lab and animal work.
Frontiers May 21, 2026

Questions about Metabolic Syndrome

Can changing my diet fix gut-liver problems causing metabolic disorders?

Changing your diet can help fix gut-liver problems that cause metabolic disorders by reducing inflammation and improving how your liver processes nutrients.

Full answer →
How do probiotics help regulate fat cells in metabolic disorders?

Probiotics and postbiotics help regulate fat cells by reducing inflammation, lowering food intake, and changing how the body absorbs fats and sugars.

Full answer →
Does eating processed meat increase my risk of metabolic disorders?

Eating processed meat is linked to a higher risk of metabolic disorders, including heart disease, diabetes, and fatty liver, according to multiple reviews.

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What are the main risk factors for Metabolic Syndrome in men?

In men, main risk factors for metabolic syndrome include abdominal obesity, high blood sugar, high triglycerides, low HDL cholesterol, high blood pressure, alcohol drinking, and a diet high in ultra-processed foods.

Full answer →
Can Tai Chi and aerobic exercise help lower Metabolic Syndrome risk factors?

Yes, both Tai Chi and aerobic exercise can help lower several Metabolic Syndrome risk factors, including blood pressure, waist circumference, and cholesterol.

Full answer →
See all 5 questions about Metabolic Syndrome →

All Metabolic Syndrome Articles