Phase 2
N=17
O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma
Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma · Stage I Mycosis Fungoides and Sezary Syndrome AJCC v7 · Stage II Mycosis Fungoides and Sezary Syndrome AJCC v7
Bottom Line
View on ClinicalTrials.gov: NCT00961220 ↗Enrolled (actual)
17
Serious AEs
0.0%
Results posted
Mar 2015
Primary outcome: Primary: Overall Response Rate — 6; 2; 8; 1 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Carmustine (Drug); Laboratory Biomarker Analysis (Other); O6-Benzylguanine (Drug)
- Age
- Adult, Older Adult · 19+ yrs
- Sex
- All
- Sponsor
- National Cancer Institute (NCI)
- Primary completion
- Apr 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Overall Response Rate |
6; 2; 8; 1 | — |
| SECONDARY Changes in AGT (O6-alkylguanine DNA Alkyltransferase) Activity |
— | — |
| SECONDARY Changes in AGT (O6-alkylguanine DNA Alkyltransferase) Activity |
— | — |
| SECONDARY Changes in AGT (O6-alkylguanine DNA Alkyltransferase) Activity |
— | — |
| SECONDARY Changes in AGT (O6-alkylguanine DNA Alkyltransferase) Activity |
— | — |
| SECONDARY Changes in the Apoptosis |
— | — |
| SECONDARY Changes in the Apoptosis |
— | — |
| SECONDARY Changes in the Cell Cycle/Proliferation |
— | — |
| SECONDARY Changes in the Cell Cycle/Proliferation |
— | — |
| SECONDARY Changes in DNA Damage- Cytotoxicity |
— | — |
| SECONDARY Changes in DNA Damage- Cytotoxicity |
— | — |
| SECONDARY Changes in AGT Inactivation in Non-responding Patients |
— | — |
| SECONDARY Changes in AGT Inactivation in Non-responding Patients |
— | — |
Summary
This phase I/II trial studies the side effects and best dose of carmustine when given together with O6-benzylguanine and to see how well they work in treating patients with stage IA-IIA cutaneous T-cell lymphoma. Drugs used in chemotherapy, such as carmustine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. O6-benzylguanine may help carmustine work better by making cancer cells more sensitive to the drug. Giving O6-benzylguanine with carmustine may kill more cancer cells.
Eligibility Criteria
Inclusion Criteria
- Diagnosis of CTCL stages IA-IIA by histopathology and immunohistochemistry in screening biopsies confirmed at Case Western Reserve University within 6 months of enrollment; biopsies may be performed at the site of collaborating institutions and shipped to University Hospitals of Cleveland-Case Western Reserve University (UHC-CWRU)
- Performance status Eastern Cooperative Oncology Group (ECOG) grade 0, 1, or 2
- Patients must have recovered from toxicity of prior treatment and have received no CTCL therapy other than emollition for at least 4 weeks, with the exception of topical corticosteroids, which may be used up to 2 weeks before the trial start date
- Patients must have signed a consent form indicating the investigational nature of the treatment and its potential side effects
- White blood cell (WBC) at least 3.5 x10E9/L
- Absolute neutrophil count (ANC) at least 1.6 x10E9/L
- Platelets > 100,000/ul
- Bilirubin = 70%; a DLCO single breath, adjusted for hemoglobin, will be utilized; we will not use DLCO/alveolar volume (VA) for inclusion or exclusion in this study
- Patients must have cutaneous disease that is amenable to biopsy and must be willing to undergo several sequential biopsies
- Must have failed at least one conventional treatment for CTCL other than topical corticosteroids; this includes phototherapy, topical mechlorethamine, topical or oral bexarotene, radiation therapy, photopheresis, chemotherapy, and immunomodulatory agents such as interferon and other retinoids
Exclusion Criteria
- Patients who have received prior treatment with topical or systemic BCNU or other nitrosoureas
- Patients with known central nervous system involvement or primary central nervous system (CNS) malignancies
- Patients with performance status ECOG grade 3 or 4
- Pregnant women, women who are breast feeding infants, or women with reproductive potential not practicing adequate contraception
- Patients with an active infection which requires hospitalization, or which may affect the patient?s safety if the patient was enrolled
- Patients with pulmonary disease as determined by history, physical examination, chest X-ray, or pulse oximetry with < 70% predicted DLCO
- CTCL patients with stage IIB-IVB disease
Data sourced from ClinicalTrials.gov (NCT00961220). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.