Phase 2 N=56 Treatment

Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage

Subarachnoid Hemorrhage · Vasospasm

Bottom Line

View on ClinicalTrials.gov: NCT00968227 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2017

Primary outcome: Primary: Change in Oxygen Delivery in Vulnerable Brain Regions — 3.7; 4.3 ml/100g/min — p=0.001

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: Red blood cell transfusion (Biological)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Washington University School of Medicine
Primary completion: Aug 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Oxygen Delivery in Vulnerable Brain Regions	3.7; 4.3	0.001 sig
SECONDARY Change in Oxygen Extraction Fraction in Regions With Low Baseline Delivery.	0.49; 0.44	—

Summary

The purpose of this study is to determine if giving blood transfusions to anemic patients with subarachnoid hemorrhage will reduce their chances of having a stroke from vasospasm.

Eligibility Criteria

Inclusion Criteria

Aneurysmal SAH confirmed by angiography
Hemoglobin < 12.5 gm/dl
One of the following:
Considered at increased risk for vasospasm by care team
Angiographic vasospasm
Delayed ischemic deficit
Able to be studied within 2 weeks after subarachnoid hemorrhage

Exclusion Criteria

Active Coronary Artery Disease
Severe congestive heart failure
Jehovah's witness
Unable to obtain appropriately matched blood
Other contraindications for transfusion
Pregnancy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00968227). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.