Phase 2
Completed N=56
Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
Subarachnoid hemorrhage · Vasospasm
Source: ClinicalTrials.gov NCT00968227 ↗
Enrolled (actual)
56
Serious AEs
0.0%
Results posted
Apr 2017
Primary outcomePrimary: Change in Oxygen Delivery in Vulnerable Brain Regions — 3.7; 4.3 ml/100g/min — p=0.001
Summary
The purpose of this study is to determine if giving blood transfusions to anemic patients with subarachnoid hemorrhage will reduce their chances of having a stroke from vasospasm.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Oxygen Delivery in Vulnerable Brain Regions |
3.7; 4.3 | 0.001 sig |
| SECONDARY Change in Oxygen Extraction Fraction in Regions With Low Baseline Delivery. |
0.49; 0.44 | — |
Eligibility Criteria
Inclusion Criteria
- Aneurysmal SAH confirmed by angiography
- Hemoglobin < 12.5 gm/dl
- One of the following:
- Considered at increased risk for vasospasm by care team
- Angiographic vasospasm
- Delayed ischemic deficit
- Able to be studied within 2 weeks after subarachnoid hemorrhage
Exclusion Criteria
- Active Coronary Artery Disease
- Severe congestive heart failure
- Jehovah's witness
- Unable to obtain appropriately matched blood
- Other contraindications for transfusion
- Pregnancy
Data sourced from ClinicalTrials.gov (NCT00968227). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.