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Subarachnoid hemorrhage

Part of Intracranial Hemorrhage

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Subarachnoid hemorrhage

16 trials tracked for Subarachnoid hemorrhage: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 18 citations.

16Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 2 7 Other / NA 6
  1. Phase 4 PRET: Patients Prone to Recurrence After Endovascular Treatment Completed · 18 cited
  2. Phase 4 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed
  3. Phase 4 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed
  4. Phase 2 Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients Completed
  5. Phase 2 Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH) Completed
  6. Phase 2 Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Completed
Show 10 more trials
  1. Phase 2 Safety Study of Dantrolene in Subarachnoid Hemorrhage Completed
  2. Phase 2 Subarachnoid Hemorrhage Recovery And Galantamine Completed
  3. Phase 2 Safety and Pharmacokinetic Evaluation of Nitrite for Prevention of Cerebral Vasospasm Completed
  4. Phase 2 Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage Completed
  5. N/A Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After aSAH Completed
  6. N/A FILtration of Subarachnoid Hemorrhage Via SpinaL CAtheteR Extension Completed
  7. N/A Ventriculostomies in SAH: ICP Open or Not? Completed
  8. N/A Preconditioning for Aneurismal Subarachnoid Hemorrhage Completed
  9. N/A CorPath® GRX Neuro Study Completed
  10. N/A Continuous Quantified EEG in NeuroIntensive Care Completed

Showing the 16 most-cited and recently-updated of 16 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Subarachnoid hemorrhage: what the trials found

Endovascular coil embolization is established for the management of subarachnoid hemorrhage 1.

Levetiracetam administration has been shown to result in extended Glasgow Outcome Scores (median values: 2, 2, 3, 3, 3, 3) in patients with this condition 2.

The use of Bactiseal TM EVD is associated with specific clinical metrics including a median time to proven infection (9.5; 10; 9.5; 10; 14; 10), a mean duration of indwelling catheter (8.7; 8.9; 9.3; 9.7; 9.8; 10.4), and specific time points for the introduction of systemic antibiotic therapy 3.

Recent results — preliminary, needs further review

  • Red blood cell transfusion was associated with a statistically significant increase in oxygen delivery in vulnerable brain regions (3.7; 4.3, p=0.001) 6.
  • Red blood cell transfusion showed a statistically significant difference in the number of units of packed red blood cells transfused (0.9; 1.5, p=0.03), though the percentage of patients receiving transfusion did not reach statistical significance (p=0.07) 7.
  • Remote limb preconditioning was evaluated for tolerability using a Visual Analog Scale (scores: 0; 3.6; 1.8; 2.5) 15.

For the clinician treating this condition

  • Endovascular coil embolization is an established intervention for subarachnoid hemorrhage 1.
  • Levetiracetam has demonstrated consistent outcomes regarding Glasgow Outcome Scores in this patient population 2.
  • Bactiseal TM EVD provides measurable data regarding infection timelines and catheter duration 3.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Intracranial Hemorrhage

Related studies from across the Intracranial Hemorrhage family.

Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus
Pediatrics Meta-analysis
Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus Blood Product Removal Shows Lower Risks for Preterm Infants
This meta-analysis of 256 preterm infants with intraventricular hemorrhage and posthemorrhagic hydrocephalus found that blood product remova…
A meta-analysis suggests blood product removal may lower mortality and infection rates in preterm infants with specific brain conditions.
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH
Neurology Meta-analysis
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH Higher Treatment Rates Linked to Better Outcomes in Brain Hemorrhages
This meta-analysis of 7,726 patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) found that higher treatment rates correlate w…
Research shows that higher treatment rates for severe brain bleeds are linked to better survival and functional recovery for patients.
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
Neurology Meta-analysis
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke Atrial Fibrillation Linked to Stroke Risk After Brain Bleed
This systematic review and meta-analysis of 198,289 adults with intracerebral hemorrhage (ICH) identifies an annual recurrence rate of 2.1% …
A large review of over 198,000 patients shows a significant link between atrial fibrillation and stroke risk following an intracerebral hemo…
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH
Neurology Sys. Review
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH AI tools may better predict bleeding in the brain
This systematic review evaluates the evolution of imaging-based prediction methods for hematoma expansion in patients with acute intracerebr…
A new review shows AI methods may predict brain bleed expansion better than traditional scans, but hurdles remain.
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear
Neurology Sys. Review
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear Remote Imaging Lesions May Predict Outcomes for Brain Bleeds
This systematic review examines remote diffusion-weighted imaging (R-DWI) lesions in patients with spontaneous intracerebral hemorrhage. The…
New imaging techniques can identify remote brain tissue damage in patients with a brain bleed, which may help doctors predict patient outcom…
Individualized shunt pressure titration may slow autologous skull graft resorption in patients with hydrocephalus
Orthopedics & Sports Medicine Sys. Review
Individualized shunt pressure titration may slow autologous skull graft resorption in patients with hydrocephalus Adjusting Shunt Pressure May Slow Skull Graft Resorption
This case report and literature review describes a patient with intracerebral hemorrhage, cerebral arteriovenous malformation, and communica…
A case study shows that tailoring shunt pressure can help manage skull graft resorption in patients with specific types of brain injuries.
MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage
Neurology Meta-analysis
MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage Minimally Invasive Surgery Shows Better Outcomes for Brain Bleeds
This network meta-analysis of 18 randomized controlled trials evaluated surgical interventions for spontaneous intracerebral hemorrhage. MIP…
New research suggests minimally invasive and endoscopic surgeries may offer better functional recovery for patients with brain bleeds compar…
Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage
Neurology RCT
Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage Single pill with three blood pressure drugs cuts stroke risk after brain bleed
This multinational randomized controlled trial enrolled 1670 patients with a history of intracerebral hemorrhage and baseline systolic blood…
A single pill combining three low-dose blood pressure drugs reduced recurrent stroke risk by 39% in people who had a brain bleed.
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men
Emergency Medicine RCT
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men Trial finds women with impaired consciousness have different outcomes
This post hoc analysis of a multicenter randomized trial included 364 critically ill adults requiring electroencephalography. Women showed h…
A trial of critically ill adults found women with impaired consciousness had higher rates of brain bleeding and seizures but similar surviva…
IVIG and platelet transfusions managed immune thrombocytopenia in a very preterm infant with intraventricular hemorrhage
Pediatrics Sys. Review
IVIG and platelet transfusions managed immune thrombocytopenia in a very preterm infant with intraventricular hemorrhage A preterm baby with low platelets improved after IVIG and transfusions
This case report and literature review describes management of immune thrombocytopenia in a very preterm male infant born to a mother with i…
A very preterm male infant born to a mother with immune thrombocytopenia improved after receiving intravenous immunoglobulin and platelet tr…
Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke
Neurology RCT
Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke Even small bleeds after minor stroke raise death risk in this trial analysis
This secondary analysis of a multicenter randomized controlled trial evaluated 865 patients with minor ischemic stroke within 12 hours of sy…
A look at trial data shows that small bleeds after minor stroke are linked to higher death rates, even if they do not worsen long-term funct…
Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients
Neurology RCT
Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients High small-vessel disease scores raise stroke risk in hemorrhage-prone patients
This post hoc analysis of a prospective, multicenter randomized controlled trial in 1,454 hemorrhage-prone patients found that higher modifi…
Patients with high small-vessel disease scores face higher risks of ischemic stroke and heart events, even if they have a history of bleedin…

Questions about Subarachnoid hemorrhage

Does where the aneurysm is located change functional outcomes in subarachnoid hemorrhage?

Research shows that aneurysm location does not significantly change mortality or functional recovery outcomes in subarachnoid hemorrhage, though specific ECG changes can vary by location.

Full answer →
What is the link between aneurysm location and survival in subarachnoid hemorrhage?

A 2025 meta-analysis found no significant difference in mortality between anterior and posterior circulation aneurysm locations in subarachnoid hemorrhage patients.

Full answer →