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Subarachnoid hemorrhage

Part of Intracranial Hemorrhage

10 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Subarachnoid hemorrhage

16 trials tracked for Subarachnoid hemorrhage: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 18 citations.

16Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 2 7 Other / NA 6
  1. Phase 4 PRET: Patients Prone to Recurrence After Endovascular Treatment Completed · 18 cited
  2. Phase 4 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed
  3. Phase 4 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed
  4. Phase 2 Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients Completed
  5. Phase 2 Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH) Completed
  6. Phase 2 Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Completed
Show 10 more trials
  1. Phase 2 Safety Study of Dantrolene in Subarachnoid Hemorrhage Completed
  2. Phase 2 Subarachnoid Hemorrhage Recovery And Galantamine Completed
  3. Phase 2 Safety and Pharmacokinetic Evaluation of Nitrite for Prevention of Cerebral Vasospasm Completed
  4. Phase 2 Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage Completed
  5. N/A Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After aSAH Completed
  6. N/A FILtration of Subarachnoid Hemorrhage Via SpinaL CAtheteR Extension Completed
  7. N/A Ventriculostomies in SAH: ICP Open or Not? Completed
  8. N/A Preconditioning for Aneurismal Subarachnoid Hemorrhage Completed
  9. N/A CorPath® GRX Neuro Study Completed
  10. N/A Continuous Quantified EEG in NeuroIntensive Care Completed

Showing the 16 most-cited and recently-updated of 16 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Subarachnoid hemorrhage: what the trials found

Endovascular coil embolization is established for the management of subarachnoid hemorrhage 1.

Levetiracetam administration has been shown to result in extended Glasgow Outcome Scores (median values: 2, 2, 3, 3, 3, 3) in patients with this condition 2.

The use of Bactiseal TM EVD is associated with specific clinical metrics including a median time to proven infection (9.5; 10; 9.5; 10; 14; 10), a mean duration of indwelling catheter (8.7; 8.9; 9.3; 9.7; 9.8; 10.4), and specific time points for the introduction of systemic antibiotic therapy 3.

Recent results — preliminary, needs further review

  • Red blood cell transfusion was associated with a statistically significant increase in oxygen delivery in vulnerable brain regions (3.7; 4.3, p=0.001) 6.
  • Red blood cell transfusion showed a statistically significant difference in the number of units of packed red blood cells transfused (0.9; 1.5, p=0.03), though the percentage of patients receiving transfusion did not reach statistical significance (p=0.07) 7.
  • Remote limb preconditioning was evaluated for tolerability using a Visual Analog Scale (scores: 0; 3.6; 1.8; 2.5) 15.

For the clinician treating this condition

  • Endovascular coil embolization is an established intervention for subarachnoid hemorrhage 1.
  • Levetiracetam has demonstrated consistent outcomes regarding Glasgow Outcome Scores in this patient population 2.
  • Bactiseal TM EVD provides measurable data regarding infection timelines and catheter duration 3.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Intracranial Hemorrhage

Related studies from across the Intracranial Hemorrhage family.

Minocycline reduces 3-month NIH Stroke Scale scores by 2.43 in acute ischemic stroke
Neurology Meta-analysis
Minocycline reduces 3-month NIH Stroke Scale scores by 2.43 in acute ischemic stroke Minocycline may improve recovery for some patients after ischemic stroke
This meta-analysis of 2186 patients with acute ischemic and intracerebral hemorrhage evaluated the impact of minocycline on neurological out…
A review of clinical data suggests the antibiotic minocycline could help some patients regain function after an ischemic stroke.
Antiseizure medication prophylaxis shows no significant difference in mortality or functional outcomes in aneurysmal subarachnoid hemorrhage
Emergency Medicine Meta-analysis
Antiseizure medication prophylaxis shows no significant difference in mortality or functional outcomes in aneurysmal subarachnoid hemorrhage Antiseizure medications show mixed results for brain bleed patients
This meta-analysis evaluates antiseizure medication (ASM) prophylaxis for adults with aneurysmal subarachnoid hemorrhage. The analysis found…
New data shows that while some antiseizure drugs may lower seizure risk after a brain bleed, they do not change overall survival rates.
Deep Learning Models Show Promise for Detecting Cerebral Microbleeds on MRI
Radiology & Imaging Meta-analysis
Deep Learning Models Show Promise for Detecting Cerebral Microbleeds on MRI Deep Learning Shows Promise for Spotting Brain Microbleeds
A meta-analysis of five patient-level studies finds deep learning models can detect cerebral microbleeds on MRI with strong diagnostic accur…
A new meta-analysis suggests deep learning can help detect tiny brain bleeds on MRI, but the evidence is still early.
Blood GFAP levels provide high specificity for identifying intracerebral hemorrhage in acute stroke patients
Neurology Meta-analysis
Blood GFAP levels provide high specificity for identifying intracerebral hemorrhage in acute stroke patients Blood tests may help doctors identify types of stroke faster
This meta-analysis evaluates the diagnostic accuracy of blood GFAP levels to differentiate intracerebral hemorrhage (ICH) from ischemic stro…
A specific protein in the blood, called GFAP, shows high accuracy in helping doctors tell the difference between types of strokes during eme…
Impact of Very Early Exercise Rehabilitation on Functional Outcomes in Intracerebral Hemorrhage
Physical Medicine & Rehab Meta-analysis
Impact of Very Early Exercise Rehabilitation on Functional Outcomes in Intracerebral Hemorrhage Very early exercise improves recovery for brain bleed patients
Meta-analysis suggests very early exercise rehabilitation improves NIHSS and Fugl-Meyer scores in stable intracerebral hemorrhage patients.
Starting exercise rehabilitation very early after a brain bleed may lead to better physical function and movement for patients.
Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage
Neurology Meta-analysis
Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage Pressure controlled irrigation may reduce brain damage after brain bleeds
Meta-analysis suggests pressure-controlled active CSF irrigation significantly reduces the odds of delayed cerebral infarction and symptomat…
A review of over 2,000 cases suggests that pressure-controlled irrigation can lower the risk of brain tissue death after a ruptured aneurysm…
Higher FIB-4 scores are associated with increased odds of poor stroke outcomes and mortality
Neurology Meta-analysis
Higher FIB-4 scores are associated with increased odds of poor stroke outcomes and mortality Higher Fibrosis Scores Linked to Worse Stroke Outcomes
This meta-analysis of 20 cohort studies and 2 cross-sectional studies examines the association between the Fibrosis-4 index (FIB-4) and vari…
A liver health score called FIB-4 shows a link to higher risks of stroke, poor recovery, and death in patients with brain injuries.
Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus
Pediatrics Meta-analysis
Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus Blood Product Removal Shows Lower Risks for Preterm Infants
This meta-analysis of 256 preterm infants with intraventricular hemorrhage and posthemorrhagic hydrocephalus found that blood product remova…
A meta-analysis suggests blood product removal may lower mortality and infection rates in preterm infants with specific brain conditions.
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH
Neurology Meta-analysis
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH Higher Treatment Rates Linked to Better Outcomes in Brain Hemorrhages
This meta-analysis of 7,726 patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) found that higher treatment rates correlate w…
Research shows that higher treatment rates for severe brain bleeds are linked to better survival and functional recovery for patients.
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
Neurology Meta-analysis
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke Atrial Fibrillation Linked to Stroke Risk After Brain Bleed
This systematic review and meta-analysis of 198,289 adults with intracerebral hemorrhage (ICH) identifies an annual recurrence rate of 2.1% …
A large review of over 198,000 patients shows a significant link between atrial fibrillation and stroke risk following an intracerebral hemo…
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH
Neurology Sys. Review
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH AI tools may better predict bleeding in the brain
This systematic review evaluates the evolution of imaging-based prediction methods for hematoma expansion in patients with acute intracerebr…
A new review shows AI methods may predict brain bleed expansion better than traditional scans, but hurdles remain.
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear
Neurology Sys. Review
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear Remote Imaging Lesions May Predict Outcomes for Brain Bleeds
This systematic review examines remote diffusion-weighted imaging (R-DWI) lesions in patients with spontaneous intracerebral hemorrhage. The…
New imaging techniques can identify remote brain tissue damage in patients with a brain bleed, which may help doctors predict patient outcom…

Questions about Subarachnoid hemorrhage

Does where the aneurysm is located change functional outcomes in subarachnoid hemorrhage?

Research shows that aneurysm location does not significantly change mortality or functional recovery outcomes in subarachnoid hemorrhage, though specific ECG changes can vary by location.

Full answer →
What is the link between aneurysm location and survival in subarachnoid hemorrhage?

A 2025 meta-analysis found no significant difference in mortality between anterior and posterior circulation aneurysm locations in subarachnoid hemorrhage patients.

Full answer →