N/A N=80 Randomized Double-blind Treatment

Pain After Laparoscopic Cholecystectomy

Postoperative Pain

Bottom Line

View on ClinicalTrials.gov: NCT00983918 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2014

Primary outcome: Primary: Pain Measured on Verbal Scale of 0-10 — 2.7; 1.7; 3; 2.1 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Desflurane (Drug); Sevoflurane (Drug); Isoflurane (Drug); Propofol (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Baylor College of Medicine
Primary completion: Jun 2010

Outcome Measures

Outcome	Result	p-value
PRIMARY Pain Measured on Verbal Scale of 0-10	2.7; 1.7; 3; 2.1	—

Summary

To the investigators' knowledge, no study has looked at differences in postoperative pain when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and propofol in laparoscopic cholecystectomy. The investigators' hypothesis is that total intravenous anesthesia with propofol will lead to less postoperative pain in the first 24 hours after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane or sevoflurane. PURPOSE To find out if maintenance of anesthesia with propofol leads to less postoperative pain after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane, or sevoflurane.

Eligibility Criteria

Inclusion Criteria

Patient ages 18-64
American Society of Anesthesiology Physical Status I, II or III
Inpatients scheduled to undergo laparoscopic cholecystectomy at Ben Taub General Hospital

Exclusion Criteria

Open cholecystectomy - excluded due to increased levels of pain in open procedures
Scheduled for ambulatory surgery
Renal dysfunction (Serum Cr > 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications
Allergy to any of the study medications or anesthetic agents
Chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone
Patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder)
Patient or surgeon refusal

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Data sourced from ClinicalTrials.gov (NCT00983918). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.