N/A
N=70
Effect of Succinylcholine on Patients Using Statins
Pain
Bottom Line
View on ClinicalTrials.gov: NCT00986583 ↗Enrolled (actual)
70
Serious AEs
0.0%
Results posted
Aug 2016
Primary outcome: Primary: Plasma Myoglobin Concentration — 46; 39; 71; 49 ug/l — p=0.018
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Succinylcholine (Drug)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- The Cleveland Clinic
- Primary completion
- Jul 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Plasma Myoglobin Concentration |
46; 39; 71; 49; 77; 47 | 0.018 sig |
| SECONDARY Muscle Pain |
34; 26; 2; 0; 1; 4 | — |
| SECONDARY Serum Potassium Concentration |
4.2; 4.2; 4.0; 3.9 | — |
| SECONDARY Change in Plasma Creatine Phosphokinase (CK) Concentration From 2 to 24 Hours Postoperatively |
175; 78 | — |
| SECONDARY Duration of Succinylcholine Block |
4.2; 4.6 | — |
| SECONDARY Fasciculation |
9; 13; 6; 3; 10; 8 | — |
Summary
Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins. The investigators' purpose is to evaluate the effect of succinylcholine on patients taking statins. Patients scheduled to undergo elective surgery (other then orthopedic, spinal, vascular or muscle) with planned endotracheal intubation will be approached regarding participation in the trial. Design of the study is complex because there is no way to randomize patients to statins or no statins and also no way to take them off the statins prior surgery. So statin use will not be randomized; confounding factors will be accounted for by stratification (every 10 years of age from 40-80 and gender) and statistical adjustment. The investigators propose to test the hypothesis that succinylcholine administration increases plasma myoglobin concentration more in patients who are on statins compared to patients who do not.
Eligibility Criteria
Inclusion Criteria
- Scheduled for elective surgery not involving orthopedic procedure, muscle and spinal surgery
- ASA Physical Status 1-3
Exclusion Criteria
- History of liver failure
- History of renal failure
- History of neuromuscular disease
- Increased intraocular pressure
- Recent major burn
- Multiple trauma
- Susceptibility to or family history of malignant hyperthermia
Data sourced from ClinicalTrials.gov (NCT00986583). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.