N/A Completed N=70 Double-blind Treatment

Effect of Succinylcholine on Patients Using Statins

Postoperative Pain

Source: ClinicalTrials.gov NCT00986583 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2016

Primary outcomePrimary: Plasma Myoglobin Concentration — 46; 39; 71; 49 ug/l — p=0.018

Summary

Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins. The investigators' purpose is to evaluate the effect of succinylcholine on patients taking statins. Patients scheduled to undergo elective surgery (other then orthopedic, spinal, vascular or muscle) with planned endotracheal intubation will be approached regarding participation in the trial. Design of the study is complex because there is no way to randomize patients to statins or no statins and also no way to take them off the statins prior surgery. So statin use will not be randomized; confounding factors will be accounted for by stratification (every 10 years of age from 40-80 and gender) and statistical adjustment. The investigators propose to test the hypothesis that succinylcholine administration increases plasma myoglobin concentration more in patients who are on statins compared to patients who do not.

Outcome Measures

Outcome	Result	p-value
PRIMARY Plasma Myoglobin Concentration	46; 39; 71; 49; 77; 47	0.018 sig
SECONDARY Muscle Pain	34; 26; 2; 0; 1; 4	—
SECONDARY Serum Potassium Concentration	4.2; 4.2; 4.0; 3.9	—
SECONDARY Change in Plasma Creatine Phosphokinase (CK) Concentration From 2 to 24 Hours Postoperatively	175; 78	—
SECONDARY Duration of Succinylcholine Block	4.2; 4.6	—
SECONDARY Fasciculation	9; 13; 6; 3; 10; 8	—

Eligibility Criteria

Inclusion Criteria

Scheduled for elective surgery not involving orthopedic procedure, muscle and spinal surgery
ASA Physical Status 1-3

Exclusion Criteria

History of liver failure
History of renal failure
History of neuromuscular disease
Increased intraocular pressure
Recent major burn
Multiple trauma
Susceptibility to or family history of malignant hyperthermia

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00986583). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.