N/A
N=28
Prophylactic Bronchoscopy After Inhalation Injury in Burn Patients
Inhalation Injury · Pneumonitis · Pneumonia
Bottom Line
View on ClinicalTrials.gov: NCT00997555 ↗Enrolled (actual)
28
Serious AEs
0.0%
Results posted
Jan 2013
Primary outcome: Primary: All Cause Mortality — 0; 1 participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- bronchoscopy (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Hurley Medical Center
- Primary completion
- Jul 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY All Cause Mortality |
0; 1 | — |
| PRIMARY Respiratory Associated Mortality |
0; 1 | — |
| SECONDARY Incidence of Pneumonia |
4; 6 | 0.6 |
| SECONDARY Length of Mechanical Ventilation |
5.1; 6.7 | 0.7 |
| SECONDARY Length of ICU Stay |
10; 18 | 0.4 |
| SECONDARY Length of Hospital Stay |
21; 26 | 0.5 |
Summary
The investigators hypothesize that the scheduled use of bronchoscopy on a regular basis after inhalation injury in burn patients will improve outcome by providing pulmonary hygiene, decrease the incidence of pneumonia, and detect pneumonia earlier than standard treatment without bronchoscopy.
Eligibility Criteria
Inclusion Criteria
- Any burned patient arriving intubated on mechanical ventilation OR requiring mechanical ventilation within 48 hours of admission AND
- > 18 years old AND
- patient believed to be able to survive more than 48 hours after arrival (not likely to be made DNR or comfort care) including:
- any methamphetamine explosion or
- any burn associated with fire (not chemical) of the face or blast injury to the face or
- confined in a burning space for more than 10 minutes or
- any burn with carbonaceous material around the nose or mouth or
- any burn > 15% TBSA associated with fire (not chemical) or
- any burn associated with an explosion in a confined space.
Exclusion Criteria
- Likely to die within 48 hours based upon severity of injury.
- Less than 18 years old.
- Burned patient transferred to our facility already on mechanical ventilation for more than 48 hours.
- Patient already on antibiotics for another reason.
Data sourced from ClinicalTrials.gov (NCT00997555). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.