N/A N=140 Randomized Single-blind Treatment

Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears

Degenerative Meniscal Tear

Bottom Line

View on ClinicalTrials.gov: NCT01002794 ↗

Enrolled (actual)

140

Serious AEs

0.0%

Results posted

Jul 2024

Primary outcome: Primary: KOOS4 - Change From Baseline — 24.4; 25.3 units on a scale — p=<0.05

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Arthroscopic partial menisectomy (Procedure); Supervised neuromuscular and strength training (Other)
Age: Adult · 35+ yrs
Sex: All
Sponsor: Oslo University Hospital
Primary completion: Jul 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY KOOS4 - Change From Baseline	—	—
PRIMARY Peak Torque Knee Extension - Change From Baseline	—	—
PRIMARY Peak Torque Knee Flexion - Change From Baseline	—	—
PRIMARY Knee Osteoarthritis Incidence	10; 9	—
PRIMARY Radiographic Progression (the Osteoarthritis Research Society International [OARSI] Atlas) [Time Frame: At 10 Years]	—	—
SECONDARY One Leg Hop Test - Change From Baseline	6.1; 11.0	—
SECONDARY 6 Meter Timed Hop Test - Change From Baseline	-0.3; -0.6	—
SECONDARY Knee Bends 30 Sec - Change From Baseline	10.6; 9.2	—
SECONDARY Peak Torque Knee Extension - Change From Baseline	—	—
SECONDARY Peak Torque Knee Flexion - Change From Baseline	—	—
SECONDARY One-leg Hop Test - Change in From Baseline	13.1; 13.2	—
SECONDARY 6 Meter Timed Hop Test - Change From Baseline	-0.3; -0.6	—
SECONDARY Knee Bends 30 Sec - Change From Baseline	10.6; 9.2	—
SECONDARY KOOS Pain - Change From Baseline	21.7; 23.2	—
SECONDARY KOOS Symptoms - Change From Baseline	12.0; 17.4	—
SECONDARY KOOS ADL - Change From Baseline	13.8; 15.4	—
SECONDARY KOOS Sport/Rec - Change From Baseline	30.8; 29.3	—
SECONDARY KOOS QOL - Change From Baseline	33.1; 31.3	—
SECONDARY SF-36 MCS - Change From Baseline	-0.3; 1.1	—
SECONDARY SF-36 PCS - Change From Baseline	7.0; 5.5	—
SECONDARY KOOS Pain Subscale - Change From Baseline	—	—
SECONDARY KOOS Symptoms Subscale - Change From Baseline	—	—
SECONDARY KOOS ADL Subscale - Change From Baseline	—	—
SECONDARY KOOS Sport/Rec Subscale - Change From Baseline	—	—
SECONDARY KOOS QOL Subscale - Change From Baseline	—	—
SECONDARY Peak Torque Knee Extension - Change From Baseline	—	—
SECONDARY Peak Torque Knee Flexion - Change From Baseline	—	—
SECONDARY Knee Osteoarthritis Incidence (Kellgren and Lawrence Classification )	—	—
SECONDARY KOOS4 - Change From Baseline	—	—
SECONDARY KOOS Pain Subscale - Change From Baseline	—	—
SECONDARY KOOS Symptoms Subscale - Change From Baseline	—	—
SECONDARY KOOS ADL Subscale - Change From Baseline	—	—
SECONDARY KOOS Sport/Rec Subscale - Change From Baseline	—	—
SECONDARY KOOS QOL Subscale - Change From Baseline	—	—
SECONDARY Peak Torque Knee Flexion - Change From Baseline	—	—
SECONDARY Peak Torque Knee Extension - Change From Baseline	—	—

Summary

This study is conducted as a collaboration between NAR, Orthopedic Department, Oslo University Hospital,Ullevaal, Hjelp24Nimi Oslo, Martina Hansens Hospital Norway, and University of Southern Denmark, Odense, Denmark. The investigators hypothesize that exercise is more effective than arthroscopic partial meniscectomy: a) on self-reported outcomes, functional performance and muscle strength in middle-aged patients subsequent to arthroscopic partial meniscectomy for a degenerative meniscus tear, and b) in preventing further development of knee osteoarthritis (OA).

Eligibility Criteria

Inclusion Criteria

Age 35-60 years
Knee pain for more than 2 months without a significant trauma
Medial meniscal tear on MRI
Eligible for arthroscopic partial meniscectomy
Grade 0-2 radiographic severity (specification after Kellgren Lawrence)

Exclusion Criteria

Those requiring acute trauma surgeries, including those treated as acute cases in the ER
Ligament injuries
Tumours (MRI)
Pain or other musculoskeletal comorbidities severely affecting lower extremity muscle function overriding the symptoms from the knee
Grade 3 or 4 radiographic severity (specification after Kellgren Lawrence)
Comorbidities excluding physical activities and exercise.
Previous knee surgery within two years
Not able to speak or read Norwegian, drug abuse or mental problems

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01002794). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.