N/A
N=28
Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception
Chronic Pain
Bottom Line
View on ClinicalTrials.gov: NCT01030133 ↗Enrolled (actual)
28
Serious AEs
0.0%
Results posted
Sep 2018
Primary outcome: Primary: Pain Unpleasantness During Perceived Control Condition — 54.5; 60.5 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Operator Role Real TMS (Device); Receiver Role Real TMS (Device); Operator Role Sham TMS (Device); Receiver Role Sham TMS (Device); All Participants Operator Role (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Medical University of South Carolina
- Primary completion
- Jan 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Unpleasantness During Perceived Control Condition |
54.5; 60.5 | — |
| PRIMARY Pain Intensity During Perceived Control Condition |
51.5; 57.5 | — |
| SECONDARY Number of Participants That Correctly Guessed Their TMS Condition Assignment |
9; 5 | 0.05 |
| SECONDARY Confidence Ratings of Guessing TMS Condition Assignment |
5.07; 5.70 | — |
Summary
Although transcranial magnetic stimulation (TMS) is now considered a minimal risk intervention, is approved for the treatment of depression, and is widely used around the world, little is known about mechanisms of action of prefrontal rTMS for depression or pain. There is some evidence that the prefrontal cortex is involved in perception of control and may moderate the effects of perceived controllability on emotional reactivity to painful stimuli. The present study aims to investigate the effects of prefrontal rTMS and perceived controllability on pain perception in healthy adults.
Eligibility Criteria
Inclusion Criteria
- 18-75 years of age
Exclusion Criteria
- history of seizures or epilepsy
- family history of seizures
- history of chronic pain conditions
- current depression
- anxiety disorders
- taking any medications shown to lower seizure threshold
- metal implants above the waist
- pregnant
- brain tumors or lesions
- pacemaker
Data sourced from ClinicalTrials.gov (NCT01030133). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.