N/A
Completed N=28
Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception
Source: ClinicalTrials.gov NCT01030133 ↗Enrolled (actual)
28
Serious AEs
0.0%
Results posted
Sep 2018
Primary outcomePrimary: Pain Unpleasantness During Perceived Control Condition — 54.5; 60.5 units on a scale
Summary
Although transcranial magnetic stimulation (TMS) is now considered a minimal risk intervention, is approved for the treatment of depression, and is widely used around the world, little is known about mechanisms of action of prefrontal rTMS for depression or pain. There is some evidence that the prefrontal cortex is involved in perception of control and may moderate the effects of perceived controllability on emotional reactivity to painful stimuli. The present study aims to investigate the effects of prefrontal rTMS and perceived controllability on pain perception in healthy adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Unpleasantness During Perceived Control Condition |
54.5; 60.5 | — |
| PRIMARY Pain Intensity During Perceived Control Condition |
51.5; 57.5 | — |
| SECONDARY Number of Participants That Correctly Guessed Their TMS Condition Assignment |
9; 5 | 0.05 |
| SECONDARY Confidence Ratings of Guessing TMS Condition Assignment |
5.07; 5.70 | — |
Eligibility Criteria
Inclusion Criteria
- 18-75 years of age
Exclusion Criteria
- history of seizures or epilepsy
- family history of seizures
- history of chronic pain conditions
- current depression
- anxiety disorders
- taking any medications shown to lower seizure threshold
- metal implants above the waist
- pregnant
- brain tumors or lesions
- pacemaker
Data sourced from ClinicalTrials.gov (NCT01030133). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.