Phase 4
Completed N=40
Effectiveness and Duration of Effect of Open Treatment in Attention Deficit Hyperactivity Disorder (ADHD) Patients Treated With Lisdexamfetamine Dimesylate(Vyvanse)
Source: ClinicalTrials.gov NCT01070394 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Nov 2016
Primary outcomePrimary: Attention Deficit Hyperactivity Disorder- Rating Scale (ADHS-RS) — 13.9 units on a scale — p=0.001
◆ Published Evidence
Established
31citations · ~2 / year
Clinical response and symptomatic remission in short- and long-term trials of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder.
Summary
The purpose of this study is to examine the effectiveness and length of effect of Vyvanse on lessening Attention-Deficit/Hyperactivity Disorder symptoms in adults. The study will also investigate the safety and tolerability of Vyvanse in adults with ADHD.
Linked Publications (2)
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Clinical response and symptomatic remission in short- and long-term trials of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder.
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Clinical effects of lisdexamfetamine and mixed amphetamine salts immediate release in adult ADHD: results of a crossover design clinical trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Attention Deficit Hyperactivity Disorder- Rating Scale (ADHS-RS) |
13.9 | 0.001 sig |
| SECONDARY Change in Symptom Rebound Score Using the Adult ADHD Medication Rebound Scale (AMRS). |
27.99; 26.9 | <.001 sig |
| SECONDARY Change in Measure of Smoothness of Effect Using Adult ADHD Medications Smoothness of Effect Scale (AMSES) |
1.31; -3.34 | .569 |
| SECONDARY Correlation Between AMRS (In Clinic) and ADHD-RS |
.66 | .001 sig |
| SECONDARY Change in Correlation Between AMRS and TASS |
.96; .96 | <.001 sig |
| SECONDARY Correlation Between In-Clinic AMRS and ASRS v.1.1 Symptom Checklist |
.83 | <.0001 sig |
| SECONDARY Psychometric Validation of AMRS |
.99; .97 | — |
| SECONDARY Psychometric Validation of AMSES |
.92; .87 | — |
Eligibility Criteria
Inclusion Criteria
- At the time of consent, are between the ages of 18-55, inclusive.
- Meet DSM-IV criteria for ADHD as assessed by the Adult ADHD Clinician Diagnostic Scale (ACDS) v1.2.
- Female participants of childbearing potential must test negative for pregnancy at the time of enrollment based on a urine pregnancy test and agree to use a reliable method of birth control during the study. Females of childbearing potential are defined as women not surgically sterilized and are between menarche and 2 years post-menopause.
- Must have a satisfactory medical assessment with no clinically significant abnormalities as determined by medical history, physical exam, ECG, and clinical laboratory testing.
- Must be able to swallow capsules.
- Must be able to begin the daily dose of study medication in the morning.
- Must be off all ADHD therapies for one week (psychostimulants) and three weeks (non-stimulants).
- In the opinion of the investigator, the subject must understand and be able, willing and likely to fully comply with the study procedures and restrictions.
- Must have given signed and dated informed consent in accordance with Good Clinical Practice (GCP) Guidelines.
Exclusion Criteria
- Participants with a positive urine drug result at Screening.
- Anyone who meets current DSM-IV-TR criteria for alcohol or any non-alcohol substance abuse or dependence disorder (excluding nicotine).
- Participants with controlled depressive or anxiety disorders may not participate if, in the opinion of the Principal Investigator, their medications will interfere with safety or efficacy assessments.
- Participants with any concurrent chronic or acute illness or unstable medical condition that could, in the opinion of the study physician, confound the results of safety assessments, increase risk to the subject or lead to difficulty complying with the protocol.
- Participants with hypertension at screening, indicated by a blood pressure reading of 135/90 and heart rate above 120bmp.
- Female participants of childbearing potential who test positive for pregnancy at the time of enrollment based on a urine pregnancy test, or who do not agree to use a reliable method of birth control during the study. Females of childbearing potential are defined as women not surgically sterilized and are between menarche and 2 years post-menopause.
- Participants who work the night shift or another schedule that would preclude beginning the daily dose of study medication in the morning.
- Participants who in the investigator's opinion meet any of the exclusionary criteria specified on the FDA label of Vyvanse.
Data sourced from ClinicalTrials.gov (NCT01070394) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.