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Attention Deficit Hyperactivity Disorder

35 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Attention Deficit Hyperactivity Disorder

268 trials tracked for Attention Deficit Hyperactivity Disorder: 154 in phase 3 or 4 and 46 with published results. The most-cited published study has 93 citations.

268Trials tracked
154Phase 3 & 4
0Recruiting
46With published results
Phase distribution
Phase 4 67 Phase 3 87 Phase 2 34 Phase 1 10 Other / NA 70
  1. Phase 3 Sleep and Tolerability Study: Comparing the Effects of Adderall XR and Focalin XR Completed · 93 cited
  2. Phase 3 Evaluation of SPN-812 (Viloxazine Extended-release Capsule) Low Dose in Children With ADHD Completed · 83 cited
  3. Phase 3 A Pivotal Efficacy Trial to Evaluate HLD200 in Children With ADHD in a Naturalistic Setting Completed · 78 cited
  4. Phase 3 A Pivotal Efficacy Trial to Evaluate HLD200 in Children With ADHD in a Classroom Setting Completed · 78 cited
  5. Phase 3 Evaluation of SPN-812 (Viloxazine Extended-release Capsule) High Dose in Children With ADHD Completed · 53 cited
  6. Phase 3 Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD Completed · 52 cited
Show 44 more trials
  1. Phase 3 NT0102 in the Treatment of Children With Attention Deficit Hyperactivity Disorder (ADHD) Completed · 42 cited
  2. Phase 4 Evaluation of an Intervention for Improving Community-based Pediatric Attention-Deficit Hyperactivity Disorder (ADHD) Care Completed · 41 cited
  3. Phase 4 Impact of Strattera and Behavior Therapy on the Home and School Functioning of Children With ADHD Completed · 38 cited
  4. Phase 3 Time Course of Response to Methylphenidate HCl ER Capsules in Children 6 to 12 Years With ADHD in Classroom Setting Completed · 38 cited
  5. Phase 3 Novel Approach to Stimulant Induced Weight Suppression and Its Impact on Growth Completed · 33 cited
  6. Phase 4 Effectiveness and Duration of Effect of Open Treatment in Attention Deficit Hyperactivity Disorder (ADHD) Patients Treated With Lisdexamfetamine Dimesylate(Vyvanse) Completed · 31 cited
  7. Phase 3 Access to Extended Release Guanfacine HCl for Subjects Who Participated in Studies SPD503-315 or SPD503-316 in Europe Completed · 29 cited
  8. Phase 3 Efficacy and Safety of Methylphenidate HCl ER Capsules in Children and Adolescents With ADHD Completed · 28 cited
  9. Phase 4 Crossover Study to Evaluate the Efficacy of AR11 in Pediatric Patients With ADHD in a Laboratory Classroom Setting Completed · 26 cited
  10. Phase 3 Safety and Efficacy Study of SHP465 in Adults Aged 18-55 Years With Attention-deficit/ Hyperactivity Disorder (ADHD) Completed · 26 cited
  11. Phase 3 Safety and Efficacy Study in Preschool Children Aged 4-5 Years With Attention-deficit/Hyperactivity Disorder (ADHD) Completed · 26 cited
  12. Phase 4 A Within-Subject Cross-Over Comparison Between Immediate Release and Extended Release Adderall Completed · 23 cited
  13. Phase 4 Methylphenidate for Attention Problems After Pediatric TBI Completed · 22 cited
  14. Phase 4 Neurobiological Basis of Response to Guanfacine Extended Release in Children and Adolescents With ADHD Completed · 21 cited
  15. Phase 3 Evaluation of SPN-812 (Viloxazine Extended-release Capsule) Low Dose in Adolescents With ADHD Completed · 19 cited
  16. Phase 3 Evaluation of SPN-812 (Viloxazine Extended-release Capsule) High Dose in Adolescents With ADHD Completed · 19 cited
  17. Phase 4 Examining Tolerance to CNS Stimulants in ADHD Completed · 18 cited
  18. Phase 3 PRC-063 Classroom Study in Children (6-12 Years of Age) With ADHD Completed · 18 cited
  19. Phase 3 A Controlled Study of Solriamfetol for Attention Deficit Hyperactivity Disorder (ADHD) in Adults Completed · 15 cited
  20. Phase 4 The Effects of Vyvanse(TM) on Brain Hemodynamics and Reading Completed · 14 cited
  21. Phase 4 Methylphenidate ER Liquid Formulation in Adults With ASD and ADHD Completed · 12 cited
  22. Phase 3 Safety and Efficacy Study of SHP465 in Children and Adolescents Aged 6-17 Years With Attention-Deficit Hyperactivity Disorder (ADHD) Completed · 12 cited
  23. Phase 3 The Efficacy and Safety of PRC-063 in Adult ADHD Patients Completed · 12 cited
  24. Phase 4 Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist Completed · 11 cited
  25. Phase 3 Dyanavel® XR Extended-Release Oral Suspension in the Treatment of Children With ADHD: A Laboratory School Study Completed · 11 cited
  26. Phase 4 Neurobiological Basis of Response to Vyvanse in Adults With ADHD: an fMRI Study of Brain Activation Completed · 10 cited
  27. Phase 4 Sequencing Treatments for Mothers With ADHD and Their At - Risk Children Completed · 9 cited
  28. Phase 3 PRC-063 Adult Laboratory Classroom Study in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD) Completed · 9 cited
  29. Phase 3 Amphetamine Extended-Release Tablets in the Treatment of Adults With ADHD Completed · 9 cited
  30. Phase 4 Pharmacokinetic Study of Methylphenidate HCl Extended-Release Capsules in Children 4 to Under 6 Years of Age With ADHD Completed · 8 cited
  31. Phase 4 Atomoxetine in Veterans With Comorbid ADHD/PTSD Completed · 8 cited
  32. Phase 3 A Trial to Evaluate the Efficacy, Safety, and Tolerability of Centanafadine Sustained-release Tablets in Adults With Attention-deficit/Hyperactivity Disorder Completed · 8 cited
  33. Phase 3 A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years Old With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting. Completed · 7 cited
  34. Phase 3 KP415 Open-Label Safety Study in Children (6-12 Years of Age) With ADHD Completed · 6 cited
  35. Phase 3 Safety and Tolerability Study of SPD489 in Preschool Children Aged 4-5 Years, Diagnosed With Attention-deficit/Hyperactivity Disorder Completed · 5 cited
  36. Phase 4 Interventions for Children With Attention and Reading Disorders Completed · 3 cited
  37. Phase 3 Adult Attention Deficit Hyperactivity Disorder (ADHD) Study With Amphetamine Sulfate Completed · 3 cited
  38. Phase 3 Open-label Long-Term Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD Completed · 3 cited
  39. Phase 4 Open-label Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD and Mood Symptoms Completed
  40. Phase 3 Efficacy and Safety of SHP465 at 6.25 mg in the Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in Children Aged 6-12 Years Completed
  41. Phase 4 Efficacy of GXR as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHD Completed
  42. Phase 4 An Open-Label Study of Naltrexone in Adults With Attention Deficit Hyperactivity Disorder. Completed
  43. Phase 4 Dose Response Effects of Quillivant XR in Children With ADHD and Autism: A Pilot Study Completed
  44. Phase 4 Omega-3 Supplementation to ADHD Medication in Children Completed

Showing the 50 most-cited and recently-updated of 268 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Attention Deficit Hyperactivity Disorder

How does grey matter development change over time in individuals with ADHD?

In ADHD, grey matter development is delayed, with smaller volumes and altered surface area trajectories that often normalize as symptoms improve into adulthood.

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Do speech features differ between children with ADHD and healthy controls?

Yes, children with ADHD show distinct speech features including lower and more variable pitch, altered spectral properties, reduced rhythmic stability, and higher subglottal pressure with lower airflow compared to healthy controls.

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Do adults with ADHD show higher emotional eating than healthy controls?

Yes, multiple studies show adults with ADHD have significantly higher emotional eating than healthy controls, linked to impulsivity and mood issues.

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Do speech features in children with ADHD change after taking medication?

Yes, a small study found that speech features in children with ADHD change after taking methylphenidate, showing reduced pitch variability and improved rhythmic stability.

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How does stigma in adult ADHD affect quality of life outcomes?

Stigma in adult ADHD is linked to worse quality of life across social, psychological, and occupational domains, with self-stigma and perceived stigma being particularly harmful.

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Does having an epidural during birth cause neurodevelopmental disorders in the baby?

No, current evidence does not show that epidural analgesia during birth causes neurodevelopmental disorders like ADHD or autism in children.

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Will transcranial direct current stimulation help reduce my child's core ADHD symptoms?

Current evidence shows transcranial direct current stimulation (tDCS) does not significantly reduce core ADHD symptoms in children, though some studies suggest possible benefits for specific cognitive functions.

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Can noise and air pollution exposure increase my child's risk for ADHD?

Yes, exposure to air pollution (PM2.5, PM10, NO2) and noise during childhood is linked to a small increased risk of ADHD, though the effect is modest and more research is needed.

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See all 8 questions about Attention Deficit Hyperactivity Disorder →

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