Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia

Key Inclusion Criteria

• Age ≥ 18
• Previously treated with relapsed or refractory disease (refractory defined as not responding to a standard regimen or progressing within 6 months of the last course of a standard regimen)
• Disease status requirement:
• For CLL patients, symptomatic disease that mandates treatment as defined by the International Workshop on Chronic Lymphocytic Lymphoma (IWCLL) 2008 criteria
• For indolent NHL and MCL patients, measurable disease by CT scan defined as at least 1 lesion that measures > 2 cm in a single dimension
• WHO performance status of ≤ 2
• For men and women of child-bearing potential, willing to use adequate contraception (ie, latex condom, cervical cap, diaphragm, abstinence, etc.) for the entire duration of the study.
• For Cohort 7 only: Women of child bearing potential must have 2 negative pregnancy tests prior to starting lenalidomide.
• Able to provide written informed consent

Key Exclusion Criteria

• Is not a good candidate to receive any of the drugs administered in the study for a given disease (idelalisib, bendamustine, rituximab, ofatumumab, fludarabine, everolimus, bortezomib, or chlorambucil), according to the clinical judgment of the investigator
• Patients with atypical immunophenotype with t(11: 14) translocation or cyclin D1 over-expression (CLL patients only)
• Had radiotherapy, radioimmunotherapy, biological therapy, chemotherapy, or treatment with an investigational product within 4-weeks prior to the baseline disease status tests
• Had treatment with a short course of corticosteroids for symptom relief within 1-week prior to the baseline disease status tests
• Has had an allogeneic hematopoietic stem cell transplant
• Has known active central nervous system involvement of the malignancy
• Is pregnant or nursing
• Has active, serious infection requiring systemic therapy. Patients may receive prophylactic antibiotics and antiviral therapy at the discretion of the investigator
• Has absolute neutrophil count (ANC) 50% infiltration of bone marrow by tumor cells
• Has platelet count 50% infiltration of bone marrow by tumor cells
• Has serum creatinine ≥ 2.0 mg/dL
• For Cohort 7 only: Has creatinine clearance < 60 mL/min
• Has serum bilirubin ≥ 2 mg/dL (unless due to Gilbert's syndrome) for patients with iNHL or CLL; for patients with MCL, serum bilirubin ≥ 1.5 x upper limit of normal
• Has serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ≥ 2 x upper limit of normal
• Has Child-Pugh Class B or C hepatic impairment
• Has a positive test for HIV antibodies
• Has active hepatitis B or C (confirmed by RNA test). Patients with serologic evidence of prior exposure are eligible.
• Prior treatment with idelalisib

Note: Other protocol defined Inclusion/Exclusion criteria may apply.