N/A
N=40
Fat Perception in Humans (09-0873)
Obesity
Bottom Line
View on ClinicalTrials.gov: NCT01128400 ↗Enrolled (actual)
40
Serious AEs
—
Results posted
Jul 2014
Primary outcome: Primary: Oleic Acid Detection Level — -0.3; -1.2; -1.0 log10 (%W/V OLEIC ACID) — p=0.05
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- Washington University School of Medicine
- Primary completion
- Jun 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Oleic Acid Detection Level |
-0.3; -1.2; -1.0 | 0.05 |
| PRIMARY Triolein Detection |
0.55; -0.33; -0.04 | 0.05 |
Summary
There are many substances naturally present in the mouth that may help us taste fat in food. Two of these substances (lipases and CD36) will be examined in this study.
The presence of fat in food increases food tastiness, therefore people often over-eat high-fat foods and gain weight. The purpose of this study is to determine if blocking lipases and some genetic variations in the CD36 gene will make fatty food less tasty so that people eat less. Our hypothesis is that Orlistat and a particular gene will increase one's ability to detect fat.
Eligibility Criteria
Inclusion Criteria
- Body Mass Index greater than 30 kg/m²
Exclusion Criteria
- smokers or who quit smoking less than six months ago
- pregnancy
- breastfeeding
- diabetes
- taking medications that might affect taste perception
- previous malabsorptive or restrictive intestinal surgery
Data sourced from ClinicalTrials.gov (NCT01128400). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.