Phase 2 Completed N=24 Randomized Quadruple-blind Treatment

D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents

Posttraumatic Stress Disorder · Post-Traumatic Stress Disorder

Source: ClinicalTrials.gov NCT01157429 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2017

Primary outcomePrimary: Child PTSD Symptom Scale (CPSS) — 20.4; 11.0 units on a scale

Summary

The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18 year-old children.

Outcome Measures

Outcome	Result	p-value
PRIMARY Child PTSD Symptom Scale (CPSS)	20.4; 11.0	—

Eligibility Criteria

Inclusion Criteria

Certain number of PTSD symptoms plus functional impairment
Must be able to swallow pills

Exclusion Criteria

Serious kidney or liver disease
Epilepsy
Bipolar disorder
Psychosis

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01157429). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.