Phase 4
N=57
Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients
Reperfusion Injury
Bottom Line
View on ClinicalTrials.gov: NCT01167569 ↗Enrolled (actual)
57
Serious AEs
0.0%
Results posted
Oct 2020
Primary outcome: Primary: Mortality — 0; 0 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Ascorbic Acid (Drug); 5 % Dextrose Water or Normal Saline (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Rutgers, The State University of New Jersey
- Primary completion
- Apr 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mortality |
0; 0 | — |
| SECONDARY Renal Insufficiency |
— | — |
Summary
It has been shown that the stress that occurs during cardiac surgery leads to early decrease of many of the body's resources such as Vitamin C (ascorbic acid) which may contribute to complications after surgery.
This study will investigate the effects of high doses of intravenous (IV) Vitamin C on the outcome and complications after cardiac surgery.
Eligibility Criteria
Inclusion Criteria
- Adult patients 18 years or older undergoing elective or urgent (prior to hospital discharge) cardiac surgery.
Exclusion Criteria
- History of renal insufficiency, nephrolithiasis, G6PD (glucose-6-phosphate dehydrogenase deficiency) or the chronic use of steroids.
Data sourced from ClinicalTrials.gov (NCT01167569). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.